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Polr3e polymerase (RNA) III (DNA directed) polypeptide E [ Mus musculus (house mouse) ]

Gene ID: 26939, updated on 5-Mar-2024

Summary

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Official Symbol
Polr3eprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Eprovided by MGI
Primary source
MGI:MGI:1349452
See related
Ensembl:ENSMUSG00000030880 AllianceGenome:MGI:1349452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sin; RPC5
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription, DNA-templated. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR3E (RNA polymerase III subunit E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 10.6), limb E14.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Polr3e in Genome Data Viewer
Location:
7 F2; 7 65.01 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120516960..120546658)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120917778..120947435)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor-2 kinase Neighboring gene predicted gene 15774 Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene cerebellar degeneration-related 2 Neighboring gene STARR-positive B cell enhancer ABC_E450 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene predicted pseudogene 9234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene. Yeganeh M, et al. Genes Dev, 2017 Feb 15. PMID 28289142, Free PMC Article
  2. Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. Danzl NM, et al. J Exp Med, 2010 May 10. PMID 20404100, Free PMC Article
  3. SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal. Dong Z, et al. Gene, 1999 Sep 17. PMID 10521666
  4. Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Riccomagno MM, et al. Neuron, 2014 Feb 19. PMID 24559672, Free PMC Article
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, affects Polr3e expression through transcriptional interference
    Title: Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene.
  2. Results identify Sin as a novel regulator of medullary thymic epithelial cell development and t cell tolerance.
    Title: Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC5
Names
RNA polymerase III polypeptide E
RNA polymerase III subunit 5
RNA polymerase III subunit C5
sex-lethal interactor homolog
sxl interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164096.2 → NP_001157568.1  DNA-directed RNA polymerase III subunit RPC5 isoform 2

    See identical proteins and their annotated locations for NP_001157568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC122248
    Consensus CDS
    CCDS52383.1
    UniProtKB/TrEMBL
    Q3TWE8, Q3UJW8
    Related
    ENSMUSP00000146970.2, ENSMUST00000207481.2
    Conserved Domains (1) summary
    pfam04801
    Location:5 → 406
    Sin_N; Sin-like protein conserved region

  2. NM_001379288.1 → NP_001366217.1  DNA-directed RNA polymerase III subunit RPC5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC122248
    UniProtKB/TrEMBL
    Q3TWE8, Q3UJW8
    Conserved Domains (1) summary
    pfam04801
    Location:5 → 436
    Sin_N; Sin-like protein conserved region

  3. NM_025298.4 → NP_079574.2  DNA-directed RNA polymerase III subunit RPC5 isoform 1

    See identical proteins and their annotated locations for NP_079574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122248
    Consensus CDS
    CCDS21797.1
    UniProtKB/Swiss-Prot
    Q8CI35, Q9CZT4, Q9DBD1
    UniProtKB/TrEMBL
    Q3TWE8, Q3UJW8
    Related
    ENSMUSP00000033173.8, ENSMUST00000033173.15
    Conserved Domains (1) summary
    pfam04801
    Location:5 → 432
    Sin_N; Sin-like protein conserved region

RNA

  1. NR_166590.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122248

  2. NR_166591.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122248

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120516960..120546658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322284.3 → XP_017177773.1  DNA-directed RNA polymerase III subunit RPC5 isoform X1

    UniProtKB/TrEMBL
    Q3TWE8, Q3UJW8
    Conserved Domains (1) summary
    pfam04801
    Location:5 → 431
    Sin_N; Sin-like protein conserved region

  2. XM_036153139.1 → XP_036009032.1  DNA-directed RNA polymerase III subunit RPC5 isoform X3

    UniProtKB/TrEMBL
    Q3TWE8, Q3UJW8
    Conserved Domains (1) summary
    pfam04801
    Location:1 → 396
    Sin_N; Sin-like protein conserved region

  3. XM_006507887.4 → XP_006507950.1  DNA-directed RNA polymerase III subunit RPC5 isoform X4

    UniProtKB/TrEMBL
    Q3UJW8
    Conserved Domains (1) summary
    pfam04801
    Location:7 → 321
    Sin_N; Sin-like protein conserved region

  4. XM_036153138.1 → XP_036009031.1  DNA-directed RNA polymerase III subunit RPC5 isoform X2

    UniProtKB/TrEMBL
    Q3TWE8, Q3UJW8
    Conserved Domains (1) summary
    pfam04801
    Location:1 → 400
    Sin_N; Sin-like protein conserved region

RNA

  1. XR_004934106.1 RNA Sequence

  2. XR_004934107.1 RNA Sequence

  3. XR_004934105.1 RNA Sequence

  4. XR_001785562.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZT4.2 GenPept UniProtKB/Swiss-Prot:Q9CZT4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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