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Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma [ Mus musculus (house mouse) ]

Gene ID: 26931, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp2r5cprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B', gammaprovided by MGI
Primary source
MGI:MGI:1349475
See related
Ensembl:ENSMUSG00000017843 AllianceGenome:MGI:1349475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D12Bwg0916e; 2610043M05Rik; 2700063L20Rik
Summary
Predicted to enable protein phosphatase activator activity. Predicted to be involved in negative regulation of cell population proliferation; protein dephosphorylation; and signal transduction by p53 class mediator. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 41.8), cortex adult (RPKM 18.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp2r5c in Genome Data Viewer
Location:
12 F1; 12 60.56 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110413532..110549509)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110447144..110583075)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9063 Neighboring gene STARR-seq mESC enhancer starr_33278 Neighboring gene STARR-seq mESC enhancer starr_33279 Neighboring gene predicted gene, 40577 Neighboring gene STARR-positive B cell enhancer ABC_E4043 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111701992-111702194 Neighboring gene STARR-seq mESC enhancer starr_33280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111716802-111717199 Neighboring gene STARR-positive B cell enhancer ABC_E5354 Neighboring gene STARR-positive B cell enhancer ABC_E1864 Neighboring gene predicted gene, 19605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111737456-111737643 Neighboring gene STARR-seq mESC enhancer starr_33286 Neighboring gene STARR-seq mESC enhancer starr_33287 Neighboring gene STARR-seq mESC enhancer starr_33292 Neighboring gene RIKEN cDNA B930059L03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111829680-111829789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111829792-111829979 Neighboring gene STARR-seq mESC enhancer starr_33294 Neighboring gene predicted gene, 35558 Neighboring gene dynein cytoplasmic 1 heavy chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PP2A-B56γ is required for an efficient spindle assembly checkpoint. Varadkar P, et al. Cell Cycle, 2017 Jun 18. PMID 28562161, Free PMC Article
  2. Localization of the PP2A B56gamma regulatory subunit at the Golgi complex: possible role in vesicle transport and migration. Ito A, et al. Am J Pathol, 2003 Feb. PMID 12547706, Free PMC Article
  3. A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression. Ito A, et al. Am J Pathol, 2003 Jan. PMID 12507892, Free PMC Article
  4. Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development. Kim JW, et al. FEBS J, 2010 Dec. PMID 21078119
  5. Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration. Kawahara E, et al. PLoS One, 2013. PMID 23704935, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of only the PP2A-B56gamma subunit can affect the efficiency of the spindle assembly checkpoint.
    Title: PP2A-B56γ is required for an efficient spindle assembly checkpoint.
  2. The PP2A B56gamma regulatory subunit controls PP2A substrate specificity in vivo in a manner that cannot be fully compensated for by other B56 subunits.
    Title: The protein phosphatase 2A B56γ regulatory subunit is required for heart development.
  3. B56gamma1 suppressed EGF-induced cell migration on collagen, bound to phosphorylated-ERK, and dephosphorylated ERK.
    Title: Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration.
  4. results suggest that Ppp2r5c expression is regulated by Nrl during retinogenesis through direct binding to the promoter region of Ppp2r5c
    Title: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development.
  5. the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A
    Title: The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition.
  6. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
    Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
  7. A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression
    Title: A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression.
  8. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
    Title: Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0044

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Names
B56/PP2A gamma
Band 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081457.3 → NP_001074926.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

    See identical proteins and their annotated locations for NP_001074926.1

    Status: VALIDATED

    Source sequence(s)
    AC152827, AK031584, CV558022
    Consensus CDS
    CCDS36558.1
    UniProtKB/Swiss-Prot
    Q60996
    Related
    ENSMUSP00000105458.2, ENSMUST00000109832.3
    Conserved Domains (1) summary
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_001081458.3 → NP_001074927.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

    See identical proteins and their annotated locations for NP_001074927.1

    Status: VALIDATED

    Source sequence(s)
    AK031584, BQ175856, CV558022
    Consensus CDS
    CCDS88404.1
    UniProtKB/TrEMBL
    Q6ZQK4
    Related
    ENSMUSP00000152865.2, ENSMUST00000221715.2
    Conserved Domains (2) summary
    PLN00122
    Location:342 → 443
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. NM_001135001.2 → NP_001128473.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform d

    Status: VALIDATED

    Source sequence(s)
    AK031584, AK129042, CJ312853, CX217314
    UniProtKB/TrEMBL
    Q6ZQK4
    Conserved Domains (2) summary
    PLN00122
    Location:399 → 500
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:91 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. NM_001364204.1 → NP_001351133.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:89 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  5. NM_001364205.1 → NP_001351134.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  6. NM_001364206.1 → NP_001351135.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Consensus CDS
    CCDS88403.1
    Related
    ENSMUSP00000152282.2, ENSMUST00000221074.2
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  7. NM_001364207.1 → NP_001351136.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 380
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  8. NM_001364208.1 → NP_001351137.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    UniProtKB/TrEMBL
    Q6ZQK4
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  9. NM_001364209.1 → NP_001351138.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform k

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 380
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  10. NM_001364210.1 → NP_001351139.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform l

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 380
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  11. NM_001364211.1 → NP_001351140.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform m

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 380
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  12. NM_001364212.1 → NP_001351141.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform n

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:19 → 357
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  13. NM_001364213.1 → NP_001351142.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform o

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 305
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  14. NM_001364214.1 → NP_001351143.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  15. NM_001373949.1 → NP_001360878.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform p

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:91 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  16. NM_001373950.1 → NP_001360879.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform q

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:91 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  17. NM_001373951.1 → NP_001360880.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform r

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    UniProtKB/TrEMBL
    Q6ZQK4
    Conserved Domains (1) summary
    pfam01603
    Location:91 → 474
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  18. NM_001373952.1 → NP_001360881.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform s

    Status: VALIDATED

    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:2 → 335
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  19. NM_001373953.1 → NP_001360882.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform t

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform t.
    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  20. NM_001373954.1 → NP_001360883.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform t

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform t.
    Source sequence(s)
    AC152827, AL591582
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  21. NM_012023.4 → NP_036153.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a

    See identical proteins and their annotated locations for NP_036153.2

    Status: VALIDATED

    Source sequence(s)
    AC152827, AK031584, CV558022, CX568604
    Consensus CDS
    CCDS36557.1
    UniProtKB/Swiss-Prot
    O35708, Q60996, Q6TQF7, Q99KW8, Q99N67, Q99N68
    Related
    ENSMUSP00000082053.4, ENSMUST00000084985.11
    Conserved Domains (2) summary
    PLN00122
    Location:342 → 442
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RNA

  1. NR_164198.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591582

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110413532..110549509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515924.4 → XP_006515987.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

    Conserved Domains (1) summary
    pfam01603
    Location:91 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. XM_006515918.4 → XP_006515981.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

    Conserved Domains (1) summary
    pfam01603
    Location:91 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_006515923.5 → XP_006515986.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

    UniProtKB/TrEMBL
    Q6ZQK4
    Conserved Domains (1) summary
    pfam01603
    Location:91 → 494
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. XM_006515921.3 → XP_006515984.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

    Conserved Domains (1) summary
    pfam01603
    Location:91 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  5. XM_030246738.2 → XP_030102598.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

    UniProtKB/TrEMBL
    Q6ZQK4
    Conserved Domains (1) summary
    pfam01603
    Location:91 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  6. XM_030246740.1 → XP_030102600.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037934.1: Suppressed sequence

    Description
    NM_001037934.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60996.2 GenPept UniProtKB/Swiss-Prot:Q60996

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