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Pask PAS domain containing serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 269224, updated on 11-Apr-2024

Summary

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Official Symbol
Paskprovided by MGI
Official Full Name
PAS domain containing serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:2155936
See related
Ensembl:ENSMUSG00000026274 AllianceGenome:MGI:2155936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0135
Summary
Predicted to enable phosphatidylinositol binding activity and protein serine/threonine kinase activity. Involved in energy homeostasis; regulation of glucagon secretion; and regulation of respiratory gaseous exchange. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain ventricular layer; colon; liver; placenta; and spleen. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 14.9), CNS E11.5 (RPKM 5.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 47.24 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93237165..93271237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93309437..93343522, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95202393-95202604 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene predicted gene 28535 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3291 Neighboring gene STARR-positive B cell enhancer ABC_E7733 Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene microRNA 6902 Neighboring gene microRNA 6345

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence. Xiao M, et al. Elife, 2023 Apr 13. PMID 37052079, Free PMC Article
  2. PAS kinase deficiency reduces aging effects in mice. Dongil P, et al. Aging (Albany NY), 2020 Jan 23. PMID 31974316, Free PMC Article
  3. Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver. Dongil P, et al. Sci Rep, 2018 Sep 14. PMID 30217996, Free PMC Article
  4. High-fat diet alters PAS kinase regulation by fasting and feeding in liver. Pérez-García A, et al. J Nutr Biochem, 2018 Jul. PMID 29649689
  5. PAS kinase drives lipogenesis through SREBP-1 maturation. Wu X, et al. Cell Rep, 2014 Jul 10. PMID 25001282, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence.
    Title: PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence.
  2. Adipose-Specific PPARalpha Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
    Title: Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
  3. Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.
    Title: Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.
  4. PAS kinase deficiency reduces aging effects in mice.
    Title: PAS kinase deficiency reduces aging effects in mice.
  5. Pask role in the liver metabolism during fasting.
    Title: High-fat diet alters PAS kinase regulation by fasting and feeding in liver.
  6. PASK regulated some of the genes and proteins responsible for glucose sensing, such as glucokinase.
    Title: PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.
  7. The findings demonstrate cell-autonomous roles for PASK in the control of pancreatic endocrine hormone secretion. Differences between the glycaemic phenotype of global vs cell type-specific null mice suggest important roles for tissue interactions in the control of glycaemia by PASK.
    Title: Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.
  8. the PAS kinase function could be critical for preserving the nutrient effect on AMP-activated protein kinase and mammalian target of rapamycin/S6K1 pathways and maintain the regulatory role of exendin-4 in food intake
    Title: PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1.
  9. PASK is a key kinase in GLP-1 actions and exerts a coordinated response with the other metabolic sensors.
    Title: PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors.
  10. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells.
    Title: Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glucagon secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PAS domain-containing serine/threonine-protein kinase
Names
PAS-kinase
paskin
NP_001408031.1
NP_001408032.1
NP_543126.2
XP_006529730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421102.1 → NP_001408031.1  PAS domain-containing serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    AC124669
    UniProtKB/Swiss-Prot
    E9QM58, Q8CEE6, Q91YD8

  2. NM_001421103.1 → NP_001408032.1  PAS domain-containing serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    AC124669
    UniProtKB/Swiss-Prot
    E9QM58, Q8CEE6, Q91YD8

  3. NM_080850.3 → NP_543126.2  PAS domain-containing serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_543126.2

    Status: VALIDATED

    Source sequence(s)
    AC124669
    Consensus CDS
    CCDS15186.1
    UniProtKB/Swiss-Prot
    E9QM58, Q8CEE6, Q91YD8
    UniProtKB/TrEMBL
    B9EKC1
    Related
    ENSMUSP00000027493.4, ENSMUST00000027493.4
    Conserved Domains (3) summary
    smart00091
    Location:342 → 388
    PAS; PAS domain
    cd00130
    Location:131 → 230
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:1058 → 1311
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93237165..93271237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529667.2 → XP_006529730.1  PAS domain-containing serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006529730.1

    UniProtKB/Swiss-Prot
    E9QM58, Q8CEE6, Q91YD8
    UniProtKB/TrEMBL
    B9EKC1
    Conserved Domains (3) summary
    smart00091
    Location:342 → 388
    PAS; PAS domain
    cd00130
    Location:131 → 230
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd14004
    Location:1058 → 1311
    STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase

RNA

  1. XR_001784731.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEE6.3 GenPept UniProtKB/Swiss-Prot:Q8CEE6

Gene LinkOut

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