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Zfp346 zinc finger protein 346 [ Mus musculus (house mouse) ]

Gene ID: 26919, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp346provided by MGI
Official Full Name
zinc finger protein 346provided by MGI
Primary source
MGI:MGI:1349417
See related
Ensembl:ENSMUSG00000021481 AllianceGenome:MGI:1349417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jaz; Znf346
Summary
Enables double-stranded RNA binding activity. Acts upstream of or within positive regulation of apoptotic process. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ZNF346 (zinc finger protein 346). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 29.8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55253079..55282884)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55105271..55135071)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4 Neighboring gene STARR-positive B cell enhancer ABC_E5399 Neighboring gene STARR-seq mESC enhancer starr_34607 Neighboring gene STARR-seq mESC enhancer starr_34609 Neighboring gene nuclear receptor-binding SET-domain protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity. Yang M, et al. Blood, 2006 Dec 15. PMID 16931621, Free PMC Article
  2. JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. Yang M, et al. J Biol Chem, 1999 Sep 24. PMID 10488071
  3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JAZ is a novel negative regulator of cell growth by positively regulating p53.
    Title: JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 346
Names
just another zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378934.1 → NP_001365863.1  zinc finger protein 346 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123709, AC154610
    UniProtKB/TrEMBL
    E9Q7N8
    Related
    ENSMUSP00000125078.2, ENSMUST00000159278.8
    Conserved Domains (2) summary
    smart00451
    Location:198 → 232
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:203 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001378935.1 → NP_001365864.1  zinc finger protein 346 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123709, AC154610
    UniProtKB/TrEMBL
    F7CTY2
    Related
    ENSMUSP00000125204.2, ENSMUST00000161077.2
    Conserved Domains (2) summary
    smart00451
    Location:198 → 232
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:75 → 97
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_012017.2 → NP_036147.1  zinc finger protein 346 isoform 1

    See identical proteins and their annotated locations for NP_036147.1

    Status: VALIDATED

    Source sequence(s)
    AK033852, AK084710, BB612150, BU706820, CV562260, CX564256
    Consensus CDS
    CCDS26539.1
    UniProtKB/Swiss-Prot
    Q9R0B7
    UniProtKB/TrEMBL
    E9Q7N8
    Related
    ENSMUSP00000021937.6, ENSMUST00000021937.12
    Conserved Domains (2) summary
    smart00451
    Location:182 → 216
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136 → 158
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_166188.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123709, AC154610

  2. NR_166189.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123709, AC154610

  3. NR_166190.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123709, AC154610

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55253079..55282884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247283.2 → XP_030103143.1  zinc finger protein 346 isoform X1

    UniProtKB/TrEMBL
    F7CTY2
    Conserved Domains (2) summary
    smart00451
    Location:194 → 228
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:148 → 170
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0B7.1 GenPept UniProtKB/Swiss-Prot:Q9R0B7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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