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Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A [ Mus musculus (house mouse) ]

Gene ID: 269181, updated on 5-Mar-2024

Summary

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Official Symbol
Mgat4aprovided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 4, isoenzyme Aprovided by MGI
Primary source
MGI:MGI:2662992
See related
Ensembl:ENSMUSG00000026110 AllianceGenome:MGI:2662992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GnT-IVa; glcNAc-T-IVa; 9530018I07Rik
Summary
Enables acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in Golgi apparatus; extracellular region; and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 27.4), colon adult (RPKM 23.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 15.46 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37478421..37580599, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37439340..37541060, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37528102-37528303 Neighboring gene STARR-positive B cell enhancer ABC_E1540 Neighboring gene G1 to S phase transition pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1541 Neighboring gene STARR-seq mESC enhancer starr_00677 Neighboring gene predicted gene, 39627 Neighboring gene STARR-positive B cell enhancer ABC_E5748 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37642841-37643028 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37643098-37643207 Neighboring gene RIKEN cDNA 4930556I23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37671888-37672102 Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene STARR-seq mESC enhancer starr_00679 Neighboring gene RIKEN cDNA 4930470B04 gene Neighboring gene STARR-seq mESC enhancer starr_00681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A). Nagae M, et al. Commun Biol, 2022 Jul 19. PMID 35854001, Free PMC Article
  2. Let-7c inhibits metastatic ability of mouse hepatocarcinoma cells via targeting mannoside acetylglucosaminyltransferase 4 isoenzyme A. Guo Y, et al. Int J Biochem Cell Biol, 2014 Aug. PMID 24769441
  3. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Ohtsubo K, et al. Cell, 2005 Dec 29. PMID 16377570
  4. Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Takamatsu S, et al. Glycobiology, 2010 Jan. PMID 20015870, Free PMC Article
  5. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin beta1 with vimentin and promotes hepatocellular carcinoma cell motility.
    Title: N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin β1 with vimentin and promotes hepatocellular carcinoma cell motility.
  2. Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A).
    Title: Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A).
  3. our results suggest that let-7c may inhibit the metastatic ability of Hca-F cells, at least partially, via repressing Mgat4a activity.
    Title: Let-7c inhibits metastatic ability of mouse hepatocarcinoma cells via targeting mannoside acetylglucosaminyltransferase 4 isoenzyme A.
  4. Mutagenesis of this gene encoding GnT-4a glycosyltransferase is studied and its association with Diabetes type 2.
    Title: Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Names
N-acetylglucosaminyltransferase IVa
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa
NP_001277730.1
NP_776295.1
XP_006496085.1
XP_006496087.1
XP_006496089.1
XP_011236828.1
XP_017176450.1
XP_017176453.1
XP_017176454.1
XP_017176455.1
XP_017176456.1
XP_036021327.1
XP_036021329.1
XP_036021332.1
XP_036021335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290801.1 → NP_001277730.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2

    See identical proteins and their annotated locations for NP_001277730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC084390, AC140321, AK035332, AK076502, AK155724, AK163327
    Consensus CDS
    CCDS69882.1
    UniProtKB/Swiss-Prot
    Q812G0
    Related
    ENSMUSP00000121181.2, ENSMUST00000154819.8
    Conserved Domains (1) summary
    pfam04666
    Location:94 → 371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  2. NM_173870.3 → NP_776295.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1

    See identical proteins and their annotated locations for NP_776295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC084390, AC140321, AK035332, AK076502, AK155724, AK163327
    Consensus CDS
    CCDS14893.1
    UniProtKB/Swiss-Prot
    Q3TQT1, Q80UI0, Q812G0
    Related
    ENSMUSP00000114175.2, ENSMUST00000151952.8
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37478421..37580599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165442.1 → XP_036021335.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

    UniProtKB/Swiss-Prot
    Q3TQT1, Q80UI0, Q812G0
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]

  2. XM_017320964.2 → XP_017176453.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:1 → 135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  3. XM_017320966.1 → XP_017176455.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:1 → 135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  4. XM_006496026.2 → XP_006496089.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    See identical proteins and their annotated locations for XP_006496089.1

    Conserved Domains (1) summary
    pfam04666
    Location:1 → 135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  5. XM_017320961.2 → XP_017176450.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X7

    Conserved Domains (1) summary
    pfam04666
    Location:94 → 371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  6. XM_017320965.1 → XP_017176454.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:1 → 135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  7. XM_017320967.1 → XP_017176456.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X9

    Conserved Domains (1) summary
    pfam04666
    Location:1 → 135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  8. XM_006496024.3 → XP_006496087.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X5

    Conserved Domains (1) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  9. XM_006496022.5 → XP_006496085.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

    See identical proteins and their annotated locations for XP_006496085.1

    UniProtKB/Swiss-Prot
    Q3TQT1, Q80UI0, Q812G0
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]

  10. XM_036165436.1 → XP_036021329.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2

    Conserved Domains (2) summary
    pfam04666
    Location:140 → 417
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:324 → 339
    PGAP4-like; putative TM2 helix [structural motif]

  11. XM_036165439.1 → XP_036021332.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X3

    Conserved Domains (2) summary
    pfam04666
    Location:131 → 408
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:315 → 330
    PGAP4-like; putative TM2 helix [structural motif]

  12. XM_036165434.1 → XP_036021327.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

    Conserved Domains (2) summary
    pfam04666
    Location:140 → 417
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:324 → 339
    PGAP4-like; putative TM2 helix [structural motif]

  13. XM_011238526.3 → XP_011236828.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X6

    See identical proteins and their annotated locations for XP_011236828.1

    UniProtKB/Swiss-Prot
    Q812G0
    Conserved Domains (1) summary
    pfam04666
    Location:94 → 371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q812G0.1 GenPept UniProtKB/Swiss-Prot:Q812G0

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