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Inpp4a inositol polyphosphate-4-phosphatase, type I [ Mus musculus (house mouse) ]

Gene ID: 269180, updated on 21-Apr-2024

Summary

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Official Symbol
Inpp4aprovided by MGI
Official Full Name
inositol polyphosphate-4-phosphatase, type Iprovided by MGI
Primary source
MGI:MGI:1931123
See related
Ensembl:ENSMUSG00000026113 AllianceGenome:MGI:1931123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
107kDa; 9630012D15; D130048C09Rik
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to act upstream of or within polyphosphate catabolic process. Located in postsynaptic density. Is expressed in several structures, including cranium; eye; integumental system; nervous system; and urinary system. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 12.1), frontal lobe adult (RPKM 10.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 15.46 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37338908..37449821)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37299827..37410740)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene predicted gene, 37020 Neighboring gene STARR-seq mESC enhancer starr_00671 Neighboring gene STARR-seq mESC enhancer starr_00672 Neighboring gene STARR-seq mESC enhancer starr_00673 Neighboring gene STARR-seq mESC enhancer starr_00674 Neighboring gene cyclic nucleotide gated channel alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E788 Neighboring gene RIKEN cDNA 4930439A04 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37374616-37374799 Neighboring gene STARR-seq mESC enhancer starr_00675 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Morioka S, et al. Innate Immun, 2016 Aug. PMID 27252170
  2. Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A). Aich J, et al. Int Immunopharmacol, 2012 Dec. PMID 22986054
  3. Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1. Ivetac I, et al. EMBO Rep, 2009 May. PMID 19325558, Free PMC Article
  4. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. Shin HW, et al. J Cell Biol, 2005 Aug 15. PMID 16103228, Free PMC Article
  5. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Vyas P, et al. Proc Natl Acad Sci U S A, 2000 Dec 5. PMID 11087841, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
    Title: Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
  2. Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
    Title: Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
  3. MicroRNA-223-3p regulates allergic in fl ammation by targeting INPP4A.
    Title: MicroRNA-223-3p regulates allergic inflammation by targeting INPP4A.
  4. this study shows that the myeloid Inpp4a-knockout mice display impaired bacteria clearance due to decreased inflammatory cytokine production
    Title: Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model.
  5. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification
    Title: Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a.
  6. This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
    Title: Behavioral effects of neonatal lesions on the cerebellar system.
  7. These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt pathway via upregulating INPP4A.
    Title: Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A).
  8. INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death
    Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
  9. Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect.
    Title: Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4.
  10. Study provides the first evidence that inositol polyphosphate 4-phosphatase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis.
    Title: Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polyphosphate catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol polyphosphate-4-phosphatase type I A
Names
4-Ptase-1
inositol polyphosphate 4-phosphatase-1
type I inositol 3,4-bisphosphate 4-phosphatase
NP_001277726.1
NP_001277727.1
NP_001277728.1
NP_001361558.1
NP_001361559.1
NP_084542.2
NP_766559.2
XP_006496069.1
XP_006496071.1
XP_006496072.1
XP_006496073.1
XP_006496074.1
XP_006496077.1
XP_006496078.1
XP_006496079.1
XP_006496080.1
XP_006496081.1
XP_006496082.1
XP_030110502.1
XP_030110505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290797.1 → NP_001277726.1  inositol polyphosphate-4-phosphatase type I A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC084390, AC133096, AF317838, AK035867, AK149414, BY274715
    Consensus CDS
    CCDS69879.1
    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    UniProtKB/TrEMBL
    D3Z230
    Related
    ENSMUSP00000121803.2, ENSMUST00000137266.8
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  2. NM_001290798.1 → NP_001277727.1  inositol polyphosphate-4-phosphatase type I A isoform 4

    See identical proteins and their annotated locations for NP_001277727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC084390, AK035867
    Consensus CDS
    CCDS78570.1
    UniProtKB/TrEMBL
    A0A0R4J0Q2, B7ZMQ9
    Related
    ENSMUSP00000057233.9, ENSMUST00000058307.15

  3. NM_001290799.1 → NP_001277728.1  inositol polyphosphate-4-phosphatase type I A isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC084390, AK035867
    UniProtKB/TrEMBL
    B7ZMQ9
    Related
    ENSMUSP00000130443.3, ENSMUST00000168546.3

  4. NM_001374629.1 → NP_001361558.1  inositol polyphosphate-4-phosphatase type I A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC084390, AC133096
    Consensus CDS
    CCDS87820.1
    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    UniProtKB/TrEMBL
    D3YUL8
    Related
    ENSMUSP00000123071.2, ENSMUST00000132401.8
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  5. NM_001374630.1 → NP_001361559.1  inositol polyphosphate-4-phosphatase type I A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC084390, AC133096
    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  6. NM_030266.4 → NP_084542.2  inositol polyphosphate-4-phosphatase type I A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses several alternate in-frame splice sites in the coding region, compared to variant 3. The encoded protein (isoform 1) is shorter than isoform 3.
    Source sequence(s)
    AC084390, AC133096, AF317838, AK035867, AK149414, BY274715
    Consensus CDS
    CCDS35539.1
    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    UniProtKB/TrEMBL
    F6V2U0
    Related
    ENSMUSP00000027287.5, ENSMUST00000027287.11
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  7. NM_172971.3 → NP_766559.2  inositol polyphosphate-4-phosphatase type I A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC084390, AK035867
    Consensus CDS
    CCDS35540.1
    UniProtKB/TrEMBL
    E9QAD0, Q0VBQ7
    Related
    ENSMUSP00000110583.3, ENSMUST00000114933.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37338908..37449821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496011.3 → XP_006496074.1  inositol polyphosphate-4-phosphatase type I A isoform X5

    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  2. XM_030254642.2 → XP_030110502.1  inositol polyphosphate-4-phosphatase type I A isoform X12

    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  3. XM_030254645.2 → XP_030110505.1  inositol polyphosphate-4-phosphatase type I A isoform X13

    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  4. XM_006496019.3 → XP_006496082.1  inositol polyphosphate-4-phosphatase type I A isoform X11

    UniProtKB/Swiss-Prot
    Q8CBJ8, Q9EPW0
    UniProtKB/TrEMBL
    E9Q9A0
    Related
    ENSMUSP00000121518.3, ENSMUST00000136846.8
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  5. XM_006496006.3 → XP_006496069.1  inositol polyphosphate-4-phosphatase type I A isoform X1

    See identical proteins and their annotated locations for XP_006496069.1

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  6. XM_006496014.3 → XP_006496077.1  inositol polyphosphate-4-phosphatase type I A isoform X6

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  7. XM_006496017.3 → XP_006496080.1  inositol polyphosphate-4-phosphatase type I A isoform X9

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  8. XM_006496018.3 → XP_006496081.1  inositol polyphosphate-4-phosphatase type I A isoform X10

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  9. XM_006496010.3 → XP_006496073.1  inositol polyphosphate-4-phosphatase type I A isoform X4

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  10. XM_006496008.3 → XP_006496071.1  inositol polyphosphate-4-phosphatase type I A isoform X2

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  11. XM_006496015.3 → XP_006496078.1  inositol polyphosphate-4-phosphatase type I A isoform X7

    UniProtKB/TrEMBL
    D3YTM1, D3YUD3, Q3UEQ1
    Related
    ENSMUSP00000115249.3, ENSMUST00000132615.8
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  12. XM_006496009.3 → XP_006496072.1  inositol polyphosphate-4-phosphatase type I A isoform X3

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  13. XM_006496016.5 → XP_006496079.1  inositol polyphosphate-4-phosphatase type I A isoform X8

    UniProtKB/TrEMBL
    D3YTM1, Q3UEQ1
    Related
    ENSMUSP00000121107.3, ENSMUST00000140264.8
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPW0.1 GenPept UniProtKB/Swiss-Prot:Q9EPW0

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