U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kif26b kinesin family member 26B [ Mus musculus (house mouse) ]

Gene ID: 269152, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Kif26bprovided by MGI
Official Full Name
kinesin family member 26Bprovided by MGI
Primary source
MGI:MGI:2447076
See related
Ensembl:ENSMUSG00000026494 AllianceGenome:MGI:2447076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4832420M10; D230039L06Rik
Summary
Predicted to enable microtubule binding activity and microtubule motor activity. Acts upstream of or within establishment of cell polarity; positive regulation of cell-cell adhesion; and ureteric bud invasion. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb interdigital region; and sensory organ. Orthologous to human KIF26B (kinesin family member 26B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 3.6), CNS E18 (RPKM 3.1) and 17 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 H4; 1 83.16 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178356690..178766765)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178529125..178932857)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03154 Neighboring gene STARR-seq mESC enhancer starr_03155 Neighboring gene predicted gene, 31289 Neighboring gene predicted gene, 39709 Neighboring gene predicted gene, 24405 Neighboring gene STARR-seq mESC enhancer starr_03157 Neighboring gene STARR-seq mESC enhancer starr_03158 Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene STARR-seq mESC enhancer starr_03160 Neighboring gene SET and MYND domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_03161 Neighboring gene STARR-seq mESC enhancer starr_03163 Neighboring gene STARR-seq mESC enhancer starr_03164 Neighboring gene STARR-seq mESC enhancer starr_03166 Neighboring gene STARR-seq mESC enhancer starr_03168 Neighboring gene STARR-seq mESC enhancer starr_03170 Neighboring gene predicted gene, 31349 Neighboring gene STARR-seq mESC enhancer starr_03171 Neighboring gene STARR-seq mESC enhancer starr_03172 Neighboring gene STARR-positive B cell enhancer ABC_E10067 Neighboring gene STARR-positive B cell enhancer ABC_E3339 Neighboring gene STARR-positive B cell enhancer mm9_chr1:181437064-181437364 Neighboring gene STARR-positive B cell enhancer mm9_chr1:181447992-181448293 Neighboring gene ribosomal protein L29 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast. Yamamura Y, et al. FASEB J, 2022 Nov. PMID 36250931
  2. Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells. Yan M, et al. Biochem Biophys Res Commun, 2022 Feb 12. PMID 35066304
  3. KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model. Yan M, et al. J Bone Miner Res, 2022 Feb. PMID 34787331
  4. The postsynaptic density protein Abelson interactor protein 1 interacts with the motor protein Kinesin family member 26B in hippocampal neurons. Heinrich J, et al. Neuroscience, 2012 Sep 27. PMID 22766233
  5. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Guillabert-Gourgues A, et al. Mol Biol Cell, 2016 Mar 15. PMID 26792835, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast.
    Title: Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast.
  2. KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model.
    Title: KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model.
  3. Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells.
    Title: Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells.
  4. Kif26b links Wnt5a-Ror signaling to the control of morphogenetic cell and tissue behaviors in vertebrates and reveal a new role for regulated proteolysis in noncanonical Wnt5a-Ror signal transduction.
    Title: Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
  5. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
    Title: Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway.
  6. Kif26b degradation in the metanephric mesenchyme via the ubiquitin-proteasome pathway may be important for proper kidney development.
    Title: Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.
  7. Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
    Title: Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
  8. KIF26B may play a role in embryogenesis, specifically in the development of limbs, face, and somites
    Title: An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC156028, MGC169313

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ureteric bud invasion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kinesin-like protein KIF26B
Names
N-11 kinesin
kinesin family protein 26b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161665.1 → NP_001155137.1  kinesin-like protein KIF26B

    See identical proteins and their annotated locations for NP_001155137.1

    Status: VALIDATED

    Source sequence(s)
    AC140776, AK052046, BC068141, CD348243
    Consensus CDS
    CCDS48464.1
    UniProtKB/Swiss-Prot
    D5MP63, E9PXV6, Q0VB48, Q7TNC6, Q8BHX2, Q8BKH6
    Related
    ENSMUSP00000124462.2, ENSMUST00000161017.8
    Conserved Domains (2) summary
    smart00129
    Location:451 → 798
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:450 → 798
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    178356690..178766765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496865.4 → XP_006496928.1  kinesin-like protein KIF26B isoform X1

    UniProtKB/TrEMBL
    E9PX64
    Related
    ENSMUSP00000124608.2, ENSMUST00000160789.2
    Conserved Domains (1) summary
    cd00106
    Location:68 → 416
    KISc; Kinesin motor domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177724.4: Suppressed sequence

    Description
    NM_177724.4: This RefSeq was permanently suppressed because the CDS was partial.

  2. NM_177757.3: Suppressed sequence

    Description
    NM_177757.3: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNC6.3 GenPept UniProtKB/Swiss-Prot:Q7TNC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous