U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cpsf7 cleavage and polyadenylation specific factor 7 [ Mus musculus (house mouse) ]

Gene ID: 269061, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cpsf7provided by MGI
Official Full Name
cleavage and polyadenylation specific factor 7provided by MGI
Primary source
MGI:MGI:1917826
See related
Ensembl:ENSMUSG00000034820 AllianceGenome:MGI:1917826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730453I16Rik; C330017N18Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA alternative polyadenylation; pre-mRNA cleavage required for polyadenylation; and protein-containing complex assembly. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including blood vessel; brain; olfactory epithelium; and retina. Orthologous to human CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 30.5), whole brain E14.5 (RPKM 27.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19 A; 19 6.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10502594..10525099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10525223..10547735)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Li N, et al. Stem Cell Reports, 2023 Jan 10. PMID 36563685, Free PMC Article
  2. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
  3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC46982

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA alternative polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA alternative polyadenylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cleavage and polyadenylation specificity factor subunit 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164272.2 → NP_001157744.1  cleavage and polyadenylation specificity factor subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001157744.1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/Swiss-Prot
    Q8BTV2
    Conserved Domains (1) summary
    cd12644
    Location:81 → 170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

  2. NM_001362450.2 → NP_001349379.1  cleavage and polyadenylation specificity factor subunit 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125093

  3. NM_172302.4 → NP_758506.3  cleavage and polyadenylation specificity factor subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_758506.3

    Status: VALIDATED

    Source sequence(s)
    AC125093
    Consensus CDS
    CCDS29579.1
    UniProtKB/Swiss-Prot
    Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
    Related
    ENSMUSP00000038958.4, ENSMUST00000038379.5
    Conserved Domains (2) summary
    COG0724
    Location:20 → 231
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12644
    Location:81 → 170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10502594..10525099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250956.2 → XP_030106816.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:23 → 101
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_006527117.4 → XP_006527180.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    See identical proteins and their annotated locations for XP_006527180.1

    Conserved Domains (1) summary
    cl17169
    Location:23 → 101
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_036161607.1 → XP_036017500.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:23 → 101
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_036161606.1 → XP_036017499.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:23 → 101
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_030250955.1 → XP_030106815.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:23 → 101
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006527116.5 → XP_006527179.1  cleavage and polyadenylation specificity factor subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006527179.1

    UniProtKB/Swiss-Prot
    Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
    Conserved Domains (2) summary
    COG0724
    Location:20 → 231
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12644
    Location:81 → 170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

  7. XM_030250954.1 → XP_030106814.1  cleavage and polyadenylation specificity factor subunit 7 isoform X2

    Conserved Domains (1) summary
    cd12644
    Location:81 → 170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

  8. XM_006527119.2 → XP_006527182.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    See identical proteins and their annotated locations for XP_006527182.1

    Conserved Domains (1) summary
    cl17169
    Location:23 → 101
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_030250958.1 → XP_030106818.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

  10. XM_036161608.1 → XP_036017501.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTV2.2 GenPept UniProtKB/Swiss-Prot:Q8BTV2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous