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4930503L19Rik RIKEN cDNA 4930503L19 gene [ Mus musculus (house mouse) ]

Gene ID: 269033, updated on 5-Mar-2024

Summary

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Official Symbol
4930503L19Rikprovided by MGI
Official Full Name
RIKEN cDNA 4930503L19 geneprovided by MGI
Primary source
MGI:MGI:1922045
See related
Ensembl:ENSMUSG00000044906 AllianceGenome:MGI:1922045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lars; Las2; 9930107F24
Summary
Acts upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human C18orf54 (chromosome 18 open reading frame 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 18.3), CNS E11.5 (RPKM 10.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E2; 18 44.42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (70585281..70605935, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (70452210..70472834, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44960 Neighboring gene dynactin associated protein like 1 Neighboring gene STARR-seq mESC enhancer starr_44961 Neighboring gene STARR-seq mESC enhancer starr_44962 Neighboring gene predicted gene, 31620 Neighboring gene STARR-positive B cell enhancer ABC_E11002 Neighboring gene StAR related lipid transfer domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E1519 Neighboring gene STARR-positive B cell enhancer ABC_E8725 Neighboring gene microRNA 6357 Neighboring gene polymerase (DNA directed), iota Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:70722848-70723181 Neighboring gene STARR-seq mESC enhancer starr_44965 Neighboring gene predicted gene, 31671 Neighboring gene methyl-CpG binding domain protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Liu PY, et al. Cancer Res, 2009 Aug 1. PMID 19622765
  2. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lung adenoma susceptibility protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379430.1 → NP_001366359.1  lung adenoma susceptibility protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162297
    UniProtKB/TrEMBL
    G8CZ46
    Conserved Domains (2) summary
    pfam15044
    Location:437 → 497
    CLU_N; Mitochondrial function, CLU-N-term
    pfam15792
    Location:143 → 211
    LAS2; Lung adenoma susceptibility protein 2

  2. NM_001379431.1 → NP_001366360.1  lung adenoma susceptibility protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162297
    UniProtKB/TrEMBL
    A0A1D5RMK7, G8CZ65
    Related
    ENSMUSP00000148818.2, ENSMUST00000212155.2
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 229
    LAS2; Lung adenoma susceptibility protein 2

  3. NM_001379432.1 → NP_001366361.1  lung adenoma susceptibility protein 2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC162297
    UniProtKB/TrEMBL
    G8CZ60
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 229
    LAS2; Lung adenoma susceptibility protein 2

  4. NM_001379433.1 → NP_001366362.1  lung adenoma susceptibility protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162297
    UniProtKB/TrEMBL
    G8CZ56, Q3UFM3
    Related
    ENSMUSP00000148553.2, ENSMUST00000212683.2
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 229
    LAS2; Lung adenoma susceptibility protein 2

  5. NM_172967.2 → NP_766555.1  lung adenoma susceptibility protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766555.1

    Status: VALIDATED

    Source sequence(s)
    AK037066
    Consensus CDS
    CCDS29333.1
    UniProtKB/Swiss-Prot
    Q8BNS5, Q8C2X0, Q8CB14
    UniProtKB/TrEMBL
    G8CZ46, G8CZ53
    Related
    ENSMUSP00000065118.4, ENSMUST00000067556.4
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 229
    LAS2; Lung adenoma susceptibility protein 2

RNA

  1. NR_166658.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162297

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    70585281..70605935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250480.2 → XP_030106340.1  lung adenoma susceptibility protein 2 isoform X2

    UniProtKB/TrEMBL
    G8CZ60, G8CZ62
    Related
    ENSMUSP00000148769.2, ENSMUST00000212982.2
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 229
    LAS2; Lung adenoma susceptibility protein 2

  2. XM_030250479.1 → XP_030106339.1  lung adenoma susceptibility protein 2 isoform X1

    UniProtKB/TrEMBL
    G8CZ60
    Conserved Domains (1) summary
    pfam15792
    Location:143 → 211
    LAS2; Lung adenoma susceptibility protein 2

RNA

  1. XR_004939858.1 RNA Sequence

  2. XR_385993.5 RNA Sequence

  3. XR_385995.3 RNA Sequence

  4. XR_003952525.2 RNA Sequence

  5. XR_004939864.1 RNA Sequence

  6. XR_004939863.1 RNA Sequence

  7. XR_385996.5 RNA Sequence

  8. XR_004939859.1 RNA Sequence

  9. XR_003952524.2 RNA Sequence

  10. XR_004939862.1 RNA Sequence

  11. XR_004939861.1 RNA Sequence

  12. XR_004939860.1 RNA Sequence

    Related
    ENSMUST00000212539.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CB14.1 GenPept UniProtKB/Swiss-Prot:Q8CB14

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