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Cops7b COP9 signalosome subunit 7B [ Mus musculus (house mouse) ]

Gene ID: 26895, updated on 5-Mar-2024

Summary

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Official Symbol
Cops7bprovided by MGI
Official Full Name
COP9 signalosome subunit 7Bprovided by MGI
Primary source
MGI:MGI:1349388
See related
Ensembl:ENSMUSG00000026240 AllianceGenome:MGI:1349388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Wsu66e; E130114M23
Summary
Predicted to be involved in protein deneddylation. Predicted to be located in nucleoplasm. Predicted to be part of COP9 signalosome. Is expressed in central nervous system; extraembryonic component; sensory organ; and skeleton. Orthologous to human COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 20.7), CNS E14 (RPKM 19.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C5; 1 43.97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86510363..86534550)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86582646..86606828)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:88428991-88429292 Neighboring gene prothymosin alpha Neighboring gene phosphodiesterase 6D, cGMP-specific, rod, delta Neighboring gene STARR-positive B cell enhancer ABC_E2552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:88483544-88483727 Neighboring gene STARR-seq mESC enhancer starr_01597 Neighboring gene predicted gene, 41908 Neighboring gene STARR-seq mESC enhancer starr_01598 Neighboring gene natriuretic peptide type C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Tomoda K, et al. J Biol Chem, 2002 Jan 18. PMID 11704659
  2. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Deng XW, et al. Trends Genet, 2000 May. PMID 10782111
  3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
  4. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Lyapina S, et al. Science, 2001 May 18. PMID 11337588
  5. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 7b
Names
COP9 (constitutive photomorphogenic) homolog, subunit 7b
COP9 complex S7b
JAB1-containing signalosome subunit 7b
SGN7b
signalosome subunit 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360887.1 → NP_001347816.1  COP9 signalosome complex subunit 7b isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC158132
    Consensus CDS
    CCDS15122.1
    UniProtKB/Swiss-Prot
    O88547, Q3TGG7, Q8BV13, Q921G4
    UniProtKB/TrEMBL
    Q3TDL0
    Conserved Domains (1) summary
    smart00088
    Location:88 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

  2. NM_001360888.1 → NP_001347817.1  COP9 signalosome complex subunit 7b isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC158132, AK053615
    Conserved Domains (2) summary
    smart00088
    Location:6 → 56
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:45 → 94
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  3. NM_172974.3 → NP_766562.1  COP9 signalosome complex subunit 7b isoform a

    See identical proteins and their annotated locations for NP_766562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC158132, AI121193, AK081309, CN721267
    Consensus CDS
    CCDS15122.1
    UniProtKB/Swiss-Prot
    O88547, Q3TGG7, Q8BV13, Q921G4
    UniProtKB/TrEMBL
    Q3TDL0
    Related
    ENSMUSP00000113587.2, ENSMUST00000121534.8
    Conserved Domains (1) summary
    smart00088
    Location:88 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    86510363..86534550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254496.2 → XP_030110356.1  COP9 signalosome complex subunit 7b isoform X2

    Conserved Domains (2) summary
    smart00088
    Location:6 → 56
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:45 → 94
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  2. XM_006529625.5 → XP_006529688.1  COP9 signalosome complex subunit 7b isoform X1

    UniProtKB/TrEMBL
    Q3TDL0
    Conserved Domains (2) summary
    smart00753
    Location:76 → 165
    PAM; PCI/PINT associated module
    pfam18392
    Location:154 → 203
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  3. XM_036165290.1 → XP_036021183.1  COP9 signalosome complex subunit 7b isoform X2

    Conserved Domains (2) summary
    smart00088
    Location:6 → 56
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:45 → 94
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BV13.1 GenPept UniProtKB/Swiss-Prot:Q8BV13

Gene LinkOut

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