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Brpf3 bromodomain and PHD finger containing, 3 [ Mus musculus (house mouse) ]

Gene ID: 268936, updated on 5-Mar-2024

Summary

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Official Symbol
Brpf3provided by MGI
Official Full Name
bromodomain and PHD finger containing, 3provided by MGI
Primary source
MGI:MGI:2146836
See related
Ensembl:ENSMUSG00000063952 AllianceGenome:MGI:2146836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1286
Summary
Predicted to enable histone binding activity. Predicted to be involved in histone H3-K14 acetylation and positive regulation of DNA replication. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; sensory organ; and skeleton. Orthologous to human BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 22.7), liver E14 (RPKM 19.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Brpf3 in Genome Data Viewer
Location:
17 A3.3; 17 15.03 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29020088..29057763)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28801126..28838789)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 14 Neighboring gene G protein subunit gamma 5C Neighboring gene STARR-seq mESC enhancer starr_42232 Neighboring gene STARR-seq mESC enhancer starr_42233 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene STARR-positive B cell enhancer ABC_E167 Neighboring gene predicted gene, 35883 Neighboring gene patatin-like phospholipase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E11634 Neighboring gene STARR-seq mESC enhancer starr_42238 Neighboring gene STARR-seq mESC enhancer starr_42239 Neighboring gene STARR-positive B cell enhancer ABC_E9947 Neighboring gene RIKEN cDNA 1700030A11 gene Neighboring gene BCL2 interacting protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival. Yan K, et al. J Biol Chem, 2016 Feb 5. PMID 26677226, Free PMC Article
  2. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. You L, et al. J Biol Chem, 2015 May 1. PMID 25773539, Free PMC Article
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon Y, et al. Mol Cell, 2006 Jan 6. PMID 16387653
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival
    Title: The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • KIAA1286, MGC58603

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain and PHD finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081315.1 → NP_001074784.1  bromodomain and PHD finger-containing protein 3

    See identical proteins and their annotated locations for NP_001074784.1

    Status: PROVISIONAL

    Source sequence(s)
    AC140278
    Consensus CDS
    CCDS37532.1
    UniProtKB/Swiss-Prot
    A0A3B2WAQ0, B2KF05, Q3TRM7
    Related
    ENSMUSP00000004985.10, ENSMUST00000004985.11
    Conserved Domains (4) summary
    cd05839
    Location:1073 → 1188
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29020088..29057763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524328.5 → XP_006524391.1  bromodomain and PHD finger-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006524391.1

    Related
    ENSMUSP00000156455.2, ENSMUST00000233701.2
    Conserved Domains (4) summary
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    PHA03307
    Location:828 → 1095
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

  2. XM_036160628.1 → XP_036016521.1  bromodomain and PHD finger-containing protein 3 isoform X3

    Conserved Domains (4) summary
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    PHA03307
    Location:831 → 1037
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

  3. XM_006524330.5 → XP_006524393.1  bromodomain and PHD finger-containing protein 3 isoform X4

    See identical proteins and their annotated locations for XP_006524393.1

    Conserved Domains (3) summary
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

  4. XM_006524331.4 → XP_006524394.1  bromodomain and PHD finger-containing protein 3 isoform X5

    See identical proteins and their annotated locations for XP_006524394.1

    UniProtKB/TrEMBL
    A0A3B2WCX7
    Conserved Domains (3) summary
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

  5. XM_006524334.4 → XP_006524397.1  bromodomain and PHD finger-containing protein 3 isoform X7

    See identical proteins and their annotated locations for XP_006524397.1

    UniProtKB/TrEMBL
    A0A3B2WD38
    Related
    ENSMUSP00000156836.2, ENSMUST00000232705.2
    Conserved Domains (2) summary
    COG5141
    Location:117 → 622
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cl22851
    Location:269 → 386
    PHD_SF; PHD finger superfamily

  6. XM_006524326.5 → XP_006524389.1  bromodomain and PHD finger-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006524389.1

    UniProtKB/Swiss-Prot
    A0A3B2WAQ0, B2KF05, Q3TRM7
    Conserved Domains (4) summary
    cd05839
    Location:1073 → 1188
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

  7. XM_030249830.2 → XP_030105690.1  bromodomain and PHD finger-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A0A3B2WAQ0, B2KF05, Q3TRM7
    Conserved Domains (4) summary
    cd05839
    Location:1073 → 1188
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:592 → 689
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:117 → 603
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15703
    Location:269 → 386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

  8. XM_006524332.5 → XP_006524395.1  bromodomain and PHD finger-containing protein 3 isoform X6

    See identical proteins and their annotated locations for XP_006524395.1

    UniProtKB/TrEMBL
    Q6ZPU7
    Related
    ENSMUSP00000156780.2, ENSMUST00000156029.8
    Conserved Domains (2) summary
    cd05839
    Location:575 → 690
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:94 → 191
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

RNA

  1. XR_003952129.2 RNA Sequence

  2. XR_004939534.1 RNA Sequence

  3. XR_385332.5 RNA Sequence

  4. XR_004939535.1 RNA Sequence

  5. XR_003952130.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199061.1: Suppressed sequence

    Description
    NM_199061.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2KF05.1 GenPept UniProtKB/Swiss-Prot:B2KF05

Gene LinkOut

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