Caskin1 CASK interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Caskin1provided by MGI
Official Full Name: CASK interacting protein 1provided by MGI
Primary source: MGI:MGI:2442952
See related: Ensembl:ENSMUSG00000033597 AllianceGenome:MGI:2442952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1306; C130061I24; 3300002N10Rik; C630036E02Rik
Summary: Predicted to enable identical protein binding activity and protein domain specific binding activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including adrenal gland; bladder; eye; intestine; and nervous system. Orthologous to human CASKIN1 (CASK interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 20.2), CNS E18 (RPKM 20.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.4 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24706871..24727883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24487897..24508909)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Title: Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Caskin1 contributes to a wide spectrum of behavioral phenotypes.
Title: Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: caskin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360469.1 → NP_001347398.1 caskin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC132367, AC154237

Consensus CDS

CCDS89007.1

UniProtKB/TrEMBL

B7ZNJ3

Related

ENSMUSP00000157196.2, ENSMUST00000234717.2

Conserved Domains (9) summary

cd09498
Location:478 → 540

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

cd12062
Location:284 → 345

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

cd00204
Location:43 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]

pfam13637
Location:7 → 69

Ank_4; Ankyrin repeats (many copies)

pfam16600
Location:373 → 421

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1298 → 1360

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:807 → 878

Caskin-Pro-rich; Proline rich region of Caskin proteins

cl25751
Location:616 → 758

DUF4045; Domain of unknown function (DUF4045)
NM_027937.2 → NP_082213.2 caskin-1 isoform 1

See identical proteins and their annotated locations for NP_082213.2

Status: VALIDATED

Source sequence(s)

BC059916, BC060720, CJ127019

Consensus CDS

CCDS50013.1

UniProtKB/Swiss-Prot

Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0

UniProtKB/TrEMBL

B7ZNJ3

Related

ENSMUSP00000024958.8, ENSMUST00000024958.9

Conserved Domains (12) summary

cd09497
Location:475 → 540

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:541 → 611

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:474 → 536

SAM; Sterile alpha motif

cd12062
Location:284 → 345

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

cd00204
Location:43 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:119 → 218

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:7 → 69

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:208 → 261

Ank_5; Ankyrin repeats (many copies)

pfam16600
Location:373 → 421

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1369 → 1431

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:878 → 949

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24706871..24727883

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524313.3 → XP_006524376.1 caskin-1 isoform X1

UniProtKB/TrEMBL

B7ZNJ3

Conserved Domains (11) summary

PTZ00449
Location:694 → 836

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09497
Location:482 → 547

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:548 → 618

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

cd12062
Location:291 → 352

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

COG0666
Location:55 → 258

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:121 → 152

ANK; ANK repeat [structural motif]

pfam12796
Location:126 → 225

Ank_2; Ankyrin repeats (3 copies)

pfam16600
Location:380 → 428

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1376 → 1438

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:885 → 956

Caskin-Pro-rich; Proline rich region of Caskin proteins

cl39094
Location:232 → 289

Ank_2; Ankyrin repeats (3 copies)
XM_030249826.1 → XP_030105686.1 caskin-1 isoform X4

UniProtKB/TrEMBL

B7ZNJ3

Conserved Domains (10) summary

PTZ00449
Location:623 → 765

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09498
Location:485 → 547

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

cd12062
Location:291 → 352

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

COG0666
Location:55 → 258

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:121 → 152

ANK; ANK repeat [structural motif]

pfam12796
Location:126 → 225

Ank_2; Ankyrin repeats (3 copies)

pfam16600
Location:380 → 428

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1305 → 1367

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:814 → 885

Caskin-Pro-rich; Proline rich region of Caskin proteins

cl39094
Location:232 → 289

Ank_2; Ankyrin repeats (3 copies)
XM_036160626.1 → XP_036016519.1 caskin-1 isoform X2

UniProtKB/TrEMBL

B7ZNJ3

Conserved Domains (11) summary

PTZ00449
Location:667 → 809

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09497
Location:455 → 520

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:521 → 591

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

cd12062
Location:264 → 325

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

COG0666
Location:28 → 231

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:94 → 125

ANK; ANK repeat [structural motif]

pfam12796
Location:99 → 198

Ank_2; Ankyrin repeats (3 copies)

pfam16600
Location:353 → 401

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1349 → 1411

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:858 → 929

Caskin-Pro-rich; Proline rich region of Caskin proteins

cl39094
Location:205 → 265

Ank_2; Ankyrin repeats (3 copies)
XM_036160627.1 → XP_036016520.1 caskin-1 isoform X3

UniProtKB/TrEMBL

B7ZNJ3

Conserved Domains (10) summary

PTZ00449
Location:660 → 802

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09497
Location:448 → 513

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:514 → 584

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

cd12062
Location:257 → 318

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

PHA03095
Location:14 → 231

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:87 → 118

ANK; ANK repeat [structural motif]

pfam12796
Location:92 → 191

Ank_2; Ankyrin repeats (3 copies)

pfam16600
Location:346 → 394

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1342 → 1404

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:851 → 922

Caskin-Pro-rich; Proline rich region of Caskin proteins
XM_006524316.5 → XP_006524379.1 caskin-1 isoform X5

Conserved Domains (5) summary

PTZ00449
Location:252 → 394

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09497
Location:42 → 105

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:106 → 176

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

pfam16632
Location:934 → 996

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:443 → 514

Caskin-Pro-rich; Proline rich region of Caskin proteins