Nrip1 nuclear receptor interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrip1provided by MGI
Official Full Name: nuclear receptor interacting protein 1provided by MGI
Primary source: MGI:MGI:1315213
See related: Ensembl:ENSMUSG00000048490 AllianceGenome:MGI:1315213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIP140; 9630050P12; 6030458L20Rik; 8430438I05Rik
Summary: Enables several functions, including histone deacetylase binding activity; retinoid X receptor binding activity; and transcription coactivator activity. Involved in circadian regulation of gene expression; lipid storage; and ovarian follicle rupture. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of histone deacetylase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in CAKUT and osteoporosis. Orthologous to human NRIP1 (nuclear receptor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 3.5), thymus adult (RPKM 2.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.1; 16 43.65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (76084291..76170930, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (76287403..76373827, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway.
Title: MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway.
Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming.
Title: Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming.
RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure.
Title: RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure.
Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model.
Title: Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model.
Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.
Title: Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.
Deletion of Nrip1 delays skin aging by reducing adipose-derived mesenchymal stem cells (ADMSCs) senescence, and maintaining ADMSCs quiescence.
Title: Deletion of Nrip1 delays skin aging by reducing adipose-derived mesenchymal stem cells (ADMSCs) senescence, and maintaining ADMSCs quiescence.
Nuclear receptor co-repressor RIP140 regulates diurnal expression of cytochrome P450 2b10 in mouse liver.
Title: Nuclear receptor co-repressor RIP140 regulates diurnal expression of cytochrome P450 2b10 in mouse liver.
NRIP is essential to maintain sarcomere structure and mitochondrial/contractile function in cardiomyocytes.
Title: Deficiency of nuclear receptor interaction protein leads to cardiomyopathy by disrupting sarcomere structure and mitochondrial respiration.
Deletion of Nrip1 can significantly extend longevity of female mice (log-rank test, p = .0004). We also found that Nrip1 expression is altered differently in various tissues during aging and under diet restriction. Remarkably, Nrip1 expression is elevated with aging in visceral white adipose tissue, but significantly reduced after 4 months of diet restriction.
Title: Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence.
RIP140 expression in osteoclast precursors and its protein regulation are crucial for osteoclast differentiation, activity, and coupled bone formation. In mice, monocyte/macrophage-specific knockdown of RIP140 resulted in a cancellous osteopenic phenotype with significantly increased bone resorption and reduced bone formation.
Title: RIP140 in monocytes/macrophages regulates osteoclast differentiation and bone homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nrip1 (e-PCR), detects polymorphism
- UniSTS:259113

RH133591 (e-PCR)
- UniSTS:216874

AA959574 (e-PCR)
- UniSTS:166010

NRIP1 (e-PCR)
- UniSTS:266424

8430438I05Rik (e-PCR), detects polymorphism
- UniSTS:259576

AF053062 (e-PCR)
- UniSTS:163578

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle rupture	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor-interacting protein 1

Names: nuclear factor RIP140; receptor-interacting protein 140

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358238.1 → NP_001345167.1 nuclear receptor-interacting protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC145744

Consensus CDS

CCDS28274.1

UniProtKB/Swiss-Prot

Q3U166, Q8C3Y8, Q8CBD1, Q9Z2K2

Related

ENSMUSP00000112959.2, ENSMUST00000121927.8

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:412 → 739

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:754 → 841

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:850 → 1161

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
NM_173440.3 → NP_775616.1 nuclear receptor-interacting protein 1

See identical proteins and their annotated locations for NP_775616.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC145744

Consensus CDS

CCDS28274.1

UniProtKB/Swiss-Prot

Q3U166, Q8C3Y8, Q8CBD1, Q9Z2K2

Related

ENSMUSP00000051726.2, ENSMUST00000054178.8

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:412 → 739

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:754 → 841

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:850 → 1161

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

76084291..76170930 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159967.1 → XP_036015860.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3U166, Q8C3Y8, Q8CBD1, Q9Z2K2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:412 → 739

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:754 → 841

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:850 → 1161

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_006523050.4 → XP_006523113.1 nuclear receptor-interacting protein 1 isoform X1

See identical proteins and their annotated locations for XP_006523113.1

UniProtKB/Swiss-Prot

Q3U166, Q8C3Y8, Q8CBD1, Q9Z2K2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:412 → 739

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:754 → 841

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:850 → 1161

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_017317020.3 → XP_017172509.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3U166, Q8C3Y8, Q8CBD1, Q9Z2K2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:412 → 739

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:754 → 841

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:850 → 1161

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_006523054.4 → XP_006523117.1 nuclear receptor-interacting protein 1 isoform X1

See identical proteins and their annotated locations for XP_006523117.1

UniProtKB/Swiss-Prot

Q3U166, Q8C3Y8, Q8CBD1, Q9Z2K2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:412 → 739

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:754 → 841

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:850 → 1161

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4