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Robo2 roundabout guidance receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 268902, updated on 21-Apr-2024

Summary

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Official Symbol
Robo2provided by MGI
Official Full Name
roundabout guidance receptor 2provided by MGI
Primary source
MGI:MGI:1890110
See related
Ensembl:ENSMUSG00000052516 AllianceGenome:MGI:1890110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1568; 2600013A04Rik; 9430089E08Rik; D230004I22Rik
Summary
Predicted to enable identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway involved in heart induction. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is expressed in several structures, including embryo mesenchyme; foot; jaw; nervous system; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 10.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.1; 16 42.17 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (73688725..75244331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (73891976..75447443, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41245 Neighboring gene predicted gene, 41472 Neighboring gene STARR-seq mESC enhancer starr_41247 Neighboring gene STARR-seq mESC enhancer starr_41248 Neighboring gene STARR-seq mESC enhancer starr_41249 Neighboring gene olfactory receptor 818 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41252 Neighboring gene STARR-seq mESC enhancer starr_41253 Neighboring gene STARR-seq mESC enhancer starr_41254 Neighboring gene STARR-seq mESC enhancer starr_41256 Neighboring gene predicted gene, 22163 Neighboring gene STARR-seq mESC enhancer starr_41258 Neighboring gene STARR-seq mESC enhancer starr_41259 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41260 Neighboring gene microRNA 691 Neighboring gene STARR-seq mESC enhancer starr_41261 Neighboring gene predicted gene, 26307 Neighboring gene predicted gene, 52242 Neighboring gene STARR-seq mESC enhancer starr_41262 Neighboring gene predicted gene, 57634 Neighboring gene STARR-seq mESC enhancer starr_41263 Neighboring gene STARR-seq mESC enhancer starr_41264 Neighboring gene predicted gene, 52278 Neighboring gene STARR-seq mESC enhancer starr_41265 Neighboring gene STARR-seq mESC enhancer starr_41266 Neighboring gene STARR-seq mESC enhancer starr_41267 Neighboring gene nuclear encoded tRNA isoleucine 1 (anticodon AAT) Neighboring gene RNA binding motif protein 11 Neighboring gene lipase, member I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction. Yuan N, et al. Ann Anat, 2023 Jun. PMID 36801365
  2. Intrauterine low-protein diet aggravates developmental abnormalities of the urinary system via the Akt/Creb3 pathway in Robo2 mutant mice. Yu M, et al. Am J Physiol Renal Physiol, 2020 Jan 1. PMID 31630547
  3. New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon. Liu J, et al. BMC Nephrol, 2016 Jul 26. PMID 27460642, Free PMC Article
  4. Overexpression of Robo2 causes defects in the recruitment of metanephric mesenchymal cells and ureteric bud branching morphogenesis. Ji J, et al. Biochem Biophys Res Commun, 2012 May 11. PMID 22521888
  5. Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2(PB/+) Gen1(PB/+) mice. Du X, et al. Biochem Biophys Res Commun, 2023 Apr 23. PMID 36870240

See all (211) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Islet architecture in adult mice is actively maintained by Robo2 expression in beta cells.
    Title: Islet architecture in adult mice is actively maintained by Robo2 expression in β cells.
  2. Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction.
    Title: Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction.
  3. Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2[PB/+] Gen1[PB/+] mice.
    Title: Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2(PB/+) Gen1(PB/+) mice.
  4. Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis.
    Title: Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis.
  5. Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
    Title: Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
  6. Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.
    Title: Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.
  7. ROBO2-mediated RALDH2 signaling is required for common nephric duct fusion with primitive bladder.
    Title: ROBO2-mediated RALDH2 signaling is required for common nephric duct fusion with primitive bladder.
  8. Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
    Title: Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
  9. investigation of how Slit/Robo signals are involved in preventing emigrant motor neurons in the spinal cord
    Title: Slit/Robo signals prevent spinal motor neuron emigration by organizing the spinal cord basement membrane.
  10. Here, the report that mammalian ROBO1 and ROBO2 are not uniformly inhibited precrossing and are instead subject to additional temporal control via alternative splicing at a conserved microexon. Postcrossing, the ROBO1 and ROBO2 isoforms are disinhibited to prevent midline reentry and to guide postcrossing commissural axons to distinct mediolateral positions.
    Title: Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables axon guidance receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aorta development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in aortic valve morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axon midline choice point recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heart induction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of negative chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory bulb interneuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in pulmonary valve morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ureteric bud development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in axolemma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
roundabout homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358490.2 → NP_001345419.1  roundabout homolog 2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC122049, AC129186, AC134452, AC158234, AC162374
    UniProtKB/TrEMBL
    Q19AB3
    Conserved Domains (5) summary
    cd05726
    Location:347 → 436
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:45 → 144
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:443 → 524
    IG_like; Immunoglobulin like
    cd00063
    Location:541 → 634
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:152 → 236
    Ig; Immunoglobulin domain

  2. NM_001358491.2 → NP_001345420.1  roundabout homolog 2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  3. NM_001358492.2 → NP_001345421.1  roundabout homolog 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  4. NM_001358493.2 → NP_001345422.1  roundabout homolog 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  5. NM_001358494.2 → NP_001345423.1  roundabout homolog 2 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC122049, AC134452, AC158234, AC162374
    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:332 → 421
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30 → 129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:428 → 509
    IG_like; Immunoglobulin like
    cd00063
    Location:526 → 619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:137 → 221
    Ig; Immunoglobulin domain

  6. NM_001415036.1 → NP_001401965.1  roundabout homolog 2 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC122049, AC134452, AC158234, AC162374
    Related
    ENSMUSP00000113795.2, ENSMUST00000117200.8

  7. NM_001415039.1 → NP_001401968.1  roundabout homolog 2 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC122049, AC134452, AC158234, AC162374
    UniProtKB/Swiss-Prot
    Q7TPD3, Q8BJ59

  8. NM_175549.6 → NP_780758.3  roundabout homolog 2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_780758.3

    Status: VALIDATED

    Source sequence(s)
    AC112155, AC122049, AC134452, AC158234, AC162374
    Consensus CDS
    CCDS49886.1
    UniProtKB/TrEMBL
    A0A2I3BR72, Q19AB2
    Related
    ENSMUSP00000112776.2, ENSMUST00000117785.9
    Conserved Domains (7) summary
    cd00096
    Location:435 → 502
    Ig; Immunoglobulin domain
    cd05726
    Location:328 → 417
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30 → 129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:424 → 505
    IG_like; Immunoglobulin like
    cd00063
    Location:522 → 615
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:225 → 310
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:137 → 221
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    73688725..75244331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159959.1 → XP_036015852.1  roundabout homolog 2 isoform X5

    UniProtKB/TrEMBL
    Q19AB3
    Conserved Domains (6) summary
    cd00063
    Location:537 → 630
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:151 → 154
    Ig; Ig strand A [structural motif]
    cd05726
    Location:330 → 427
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:46 → 144
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:434 → 520
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:151 → 236
    Ig; Immunoglobulin domain

  2. XM_006523038.4 → XP_006523101.1  roundabout homolog 2 isoform X4

    UniProtKB/TrEMBL
    Q19AB3
    Conserved Domains (5) summary
    cd05726
    Location:347 → 436
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:45 → 144
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:443 → 524
    IG_like; Immunoglobulin like
    cd00063
    Location:541 → 634
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:152 → 236
    Ig; Immunoglobulin domain

  3. XM_030249139.1 → XP_030104999.1  roundabout homolog 2 isoform X4

    UniProtKB/TrEMBL
    Q19AB3
    Conserved Domains (5) summary
    cd05726
    Location:347 → 436
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:45 → 144
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:443 → 524
    IG_like; Immunoglobulin like
    cd00063
    Location:541 → 634
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:152 → 236
    Ig; Immunoglobulin domain

  4. XM_030249140.1 → XP_030105000.1  roundabout homolog 2 isoform X4

    UniProtKB/TrEMBL
    Q19AB3
    Conserved Domains (5) summary
    cd05726
    Location:347 → 436
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:45 → 144
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:443 → 524
    IG_like; Immunoglobulin like
    cd00063
    Location:541 → 634
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:152 → 236
    Ig; Immunoglobulin domain

  5. XM_006523049.5 → XP_006523112.1  roundabout homolog 2 isoform X24

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:351 → 440
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:447 → 528
    IG_like; Immunoglobulin like
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  6. XM_036159962.1 → XP_036015855.1  roundabout homolog 2 isoform X16

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  7. XM_036159961.1 → XP_036015854.1  roundabout homolog 2 isoform X9

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  8. XM_036159965.1 → XP_036015858.1  roundabout homolog 2 isoform X22

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  9. XM_036159964.1 → XP_036015857.1  roundabout homolog 2 isoform X21

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  10. XM_006523042.5 → XP_006523105.1  roundabout homolog 2 isoform X11

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:351 → 440
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:447 → 528
    IG_like; Immunoglobulin like
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  11. XM_006523037.5 → XP_006523100.1  roundabout homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:351 → 440
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:447 → 528
    IG; Immunoglobulin
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  12. XM_017317016.3 → XP_017172505.1  roundabout homolog 2 isoform X23

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  13. XM_006523046.5 → XP_006523109.1  roundabout homolog 2 isoform X15

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  14. XM_036159963.1 → XP_036015856.1  roundabout homolog 2 isoform X18

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  15. XM_011246131.4 → XP_011244433.1  roundabout homolog 2 isoform X17

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451 → 532
    IG; Immunoglobulin
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  16. XM_006523040.5 → XP_006523103.1  roundabout homolog 2 isoform X8

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451 → 532
    IG; Immunoglobulin
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  17. XM_006523048.5 → XP_006523111.1  roundabout homolog 2 isoform X20

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  18. XM_017317015.3 → XP_017172504.1  roundabout homolog 2 isoform X19

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  19. XM_006523041.5 → XP_006523104.1  roundabout homolog 2 isoform X10

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451 → 532
    IG_like; Immunoglobulin like
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  20. XM_030249141.2 → XP_030105001.1  roundabout homolog 2 isoform X14

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451 → 532
    IG; Immunoglobulin
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  21. XM_006523045.5 → XP_006523108.1  roundabout homolog 2 isoform X13

    UniProtKB/TrEMBL
    E9Q6A0
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451 → 532
    IG; Immunoglobulin
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  22. XM_006523036.5 → XP_006523099.1  roundabout homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451 → 532
    IG; Immunoglobulin
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  23. XM_006523035.5 → XP_006523098.1  roundabout homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:355 → 444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53 → 152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451 → 532
    IG; Immunoglobulin
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:160 → 244
    Ig; Immunoglobulin domain

  24. XM_036159960.1 → XP_036015853.1  roundabout homolog 2 isoform X7

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (6) summary
    cd00063
    Location:522 → 615
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:136 → 139
    Ig; Ig strand A [structural motif]
    cd05726
    Location:315 → 412
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:31 → 129
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:419 → 505
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:136 → 221
    Ig; Immunoglobulin domain

  25. XM_006523043.5 → XP_006523106.1  roundabout homolog 2 isoform X12

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:332 → 421
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30 → 129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:428 → 509
    IG_like; Immunoglobulin like
    cd00063
    Location:526 → 619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:137 → 221
    Ig; Immunoglobulin domain

  26. XM_006523039.5 → XP_006523102.1  roundabout homolog 2 isoform X6

    UniProtKB/TrEMBL
    A0A2I3BR72
    Conserved Domains (5) summary
    cd05726
    Location:332 → 421
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30 → 129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:428 → 509
    IG_like; Immunoglobulin like
    cd00063
    Location:526 → 619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:137 → 221
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPD3.2 GenPept UniProtKB/Swiss-Prot:Q7TPD3

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