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Lsamp limbic system-associated membrane protein [ Mus musculus (house mouse) ]

Gene ID: 268890, updated on 5-Mar-2024

Summary

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Official Symbol
Lsampprovided by MGI
Official Full Name
limbic system-associated membrane proteinprovided by MGI
Primary source
MGI:MGI:1261760
See related
Ensembl:ENSMUSG00000061080 AllianceGenome:MGI:1261760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lam; Lamp; Gm29907; 5430428I19; B130007O04Rik; D930023J12Rik
Summary
Acts upstream of or within locomotory exploration behavior. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human LSAMP (limbic system associated membrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 15.7), cortex adult (RPKM 9.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Lsamp in Genome Data Viewer
Location:
16; 16 B4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (39804674..42002042)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (39984254..42181679)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53954 Neighboring gene predicted gene, 36903 Neighboring gene STARR-seq mESC enhancer starr_40842 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53260 Neighboring gene predicted gene, 22543 Neighboring gene STARR-seq mESC enhancer starr_40843 Neighboring gene zinc finger protein 777 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40844 Neighboring gene STARR-seq mESC enhancer starr_40845 Neighboring gene STARR-seq mESC enhancer starr_40846 Neighboring gene STARR-seq mESC enhancer starr_40847 Neighboring gene predicted gene, 52230 Neighboring gene STARR-seq mESC enhancer starr_40848 Neighboring gene STARR-seq mESC enhancer starr_40849 Neighboring gene STARR-seq mESC enhancer starr_40850 Neighboring gene STARR-seq mESC enhancer starr_40851 Neighboring gene STARR-seq mESC enhancer starr_40852 Neighboring gene STARR-seq mESC enhancer starr_40853 Neighboring gene STARR-seq mESC enhancer starr_40854 Neighboring gene STARR-seq mESC enhancer starr_40855 Neighboring gene predicted gene, 53955 Neighboring gene STARR-seq mESC enhancer starr_40856 Neighboring gene predicted gene, 53259 Neighboring gene STARR-seq mESC enhancer starr_40857 Neighboring gene STARR-seq mESC enhancer starr_40858 Neighboring gene predicted gene, 46551 Neighboring gene STARR-seq mESC enhancer starr_40859 Neighboring gene predicted gene, 52229 Neighboring gene STARR-seq mESC enhancer starr_40861 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene microRNA 6540 Neighboring gene growth associated protein 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lsamp⁻/⁻ mice display lower sensitivity to amphetamine and have elevated 5-HT turnover. Innos J, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23206697
  2. Deletion of the Lsamp gene lowers sensitivity to stressful environmental manipulations in mice. Innos J, et al. Behav Brain Res, 2012 Mar 1. PMID 22155487
  3. Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice. Innos J, et al. Behav Brain Res, 2011 Feb 2. PMID 20888367
  4. Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit. Qiu S, et al. Biol Psychiatry, 2010 Jul 15. PMID 20385375, Free PMC Article
  5. The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse. Singh K, et al. Brain Res Bull, 2018 Jun. PMID 29605488

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotyping neurons derived from the hippocampi of Lsamp(-/-), Ntm(-/-) and Lsamp(-/-)Ntm(-/-) mice was performed in parallel with behavioral testing. Lsamp appears to be an enhancer of neurite outgrowth as premature neuritogenesis in Ntm(-/-) neurons is apparent only in the presence of Lsamp. Lsamp appeared to be a positive regulator of apoptosis in the presence of Ntm.
    Title: The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse.
  2. Limbic system-associated membrane protein is involved in emotional and social operating systems by complex regulation of two alternative promoters.
    Title: Lsamp is implicated in the regulation of emotional and social behavior by use of alternative promoters in the brain.
  3. Lsamp(-/-) mice are a promising model to study the neurobiological mechanisms of deviant social behaviour and adaptation impairment observed in many psychiatric disorders.
    Title: Lsamp⁻/⁻ mice display lower sensitivity to amphetamine and have elevated 5-HT turnover.
  4. Lsamp-deficient mice were less sensitive to isolation stress than their wild-type littermates.
    Title: Deletion of the Lsamp gene lowers sensitivity to stressful environmental manipulations in mice.
  5. results suggest that LAMP protein is not crucial for the general development of anatomical brain structures, but is needed for specific neural circuits that regulate anxiety-related and social behaviour.
    Title: Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice.
  6. lsamp knockout mice have a deficit in spatial memory acquisition and poorly sustained CA1 long-term potentiation.
    Title: Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit.
  7. Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments.
    Title: Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments.
  8. genomic features of the Lsamp gene indicate an intricate mechanism of gene expression regulation that may be relevant in the context of human neuropsychiatric and neurological disorders, where LAMP expression may be altered
    Title: Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
limbic system-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347236.2 → NP_001334165.1  limbic system-associated membrane protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102503, AC122207, AC124565, AC154341, AC163665
    Consensus CDS
    CCDS84234.1
    UniProtKB/Swiss-Prot
    Q8BLK3
    UniProtKB/TrEMBL
    Q3TYE5
    Related
    ENSMUSP00000097349.4, ENSMUST00000099761.10
    Conserved Domains (2) summary
    pfam13927
    Location:219 → 294
    Ig_3; Immunoglobulin domain
    cl11960
    Location:38 → 128
    Ig; Immunoglobulin domain

  2. NM_001361281.2 → NP_001348210.1  limbic system-associated membrane protein isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102503, AC116106, AC122207, AC124565, AC131108, AC154341, AC163665
    Consensus CDS
    CCDS88928.1
    UniProtKB/TrEMBL
    A0A087WP80
    Related
    ENSMUSP00000139667.2, ENSMUST00000187695.7
    Conserved Domains (2) summary
    pfam13927
    Location:236 → 311
    Ig_3; Immunoglobulin domain
    cl11960
    Location:55 → 145
    Ig; Immunoglobulin domain

  3. NM_001361282.2 → NP_001348211.1  limbic system-associated membrane protein isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102503, AC116106, AC122207, AC124565, AC131108, AC154341, AC163665
    Conserved Domains (2) summary
    pfam13927
    Location:236 → 311
    Ig_3; Immunoglobulin domain
    cl11960
    Location:55 → 145
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    39804674..42002042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159957.1 → XP_036015850.1  limbic system-associated membrane protein isoform X4

    UniProtKB/Swiss-Prot
    Q8BLK3
    Conserved Domains (3) summary
    pfam13927
    Location:249 → 325
    Ig_3; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand B [structural motif]
    cl11960
    Location:69 → 159
    Ig; Immunoglobulin domain

  2. XM_030249137.2 → XP_030104997.1  limbic system-associated membrane protein isoform X1

    Conserved Domains (2) summary
    pfam13927
    Location:250 → 325
    Ig_3; Immunoglobulin domain
    cl11960
    Location:69 → 159
    Ig; Immunoglobulin domain

  3. XM_036159956.1 → XP_036015849.1  limbic system-associated membrane protein isoform X2

    Conserved Domains (3) summary
    pfam13927
    Location:249 → 325
    Ig_3; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand B [structural motif]
    cl11960
    Location:69 → 159
    Ig; Immunoglobulin domain

  4. XM_030249138.2 → XP_030104998.1  limbic system-associated membrane protein isoform X3

    Conserved Domains (2) summary
    pfam13927
    Location:250 → 325
    Ig_3; Immunoglobulin domain
    cl11960
    Location:69 → 159
    Ig; Immunoglobulin domain

  5. XM_006522201.4 → XP_006522264.2  limbic system-associated membrane protein isoform X5

    UniProtKB/Swiss-Prot
    Q8BLK3
    Conserved Domains (2) summary
    pfam13927
    Location:211 → 286
    Ig_3; Immunoglobulin domain
    cl11960
    Location:30 → 120
    Ig; Immunoglobulin domain

  6. XM_036159958.1 → XP_036015851.1  limbic system-associated membrane protein isoform X6

    UniProtKB/Swiss-Prot
    Q8BLK3
    Conserved Domains (3) summary
    pfam13927
    Location:210 → 286
    Ig_3; Immunoglobulin domain
    cd00096
    Location:227 → 231
    Ig; Ig strand B [structural motif]
    cl11960
    Location:30 → 120
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175548.3: Suppressed sequence

    Description
    NM_175548.3: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLK3.1 GenPept UniProtKB/Swiss-Prot:Q8BLK3

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