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Cenph centromere protein H [ Mus musculus (house mouse) ]

Gene ID: 26886, updated on 8-May-2024

Summary

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Official Symbol
Cenphprovided by MGI
Official Full Name
centromere protein Hprovided by MGI
Primary source
MGI:MGI:1349448
See related
Ensembl:ENSMUSG00000045273 AllianceGenome:MGI:1349448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENP; CENP-H; 1700021I11Rik; 2410018A12Rik; 2610042E16Rik; 2810046K12Rik
Summary
Enables kinetochore binding activity. Predicted to be involved in chromosome segregation and mitotic spindle organization. Predicted to act upstream of or within mitotic cell cycle. Located in kinetochore and nucleus. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; hemolymphoid system gland; and skin. Orthologous to human CENPH (centromere protein H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 15.8), CNS E11.5 (RPKM 12.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 53.23 cM; 13 D1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100896187..100912415, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100759674..100775903, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin dependent kinase 7 Neighboring gene STARR-seq mESC enhancer starr_35477 Neighboring gene STARR-positive B cell enhancer ABC_E7269 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene STARR-positive B cell enhancer ABC_E1886 Neighboring gene STARR-seq mESC enhancer starr_35481 Neighboring gene cyclin B1 Neighboring gene solute carrier family 30 (zinc transporter), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E4088

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. Zhang T, et al. Development, 2017 Jan 15. PMID 27993978, Free PMC Article
  2. CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells. Fukagawa T, et al. EMBO J, 2001 Aug 15. PMID 11500386, Free PMC Article
  3. Characterization of a novel kinetochore protein, CENP-H. Sugata N, et al. J Biol Chem, 1999 Sep 24. PMID 10488063
  4. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. Sugata N, et al. Hum Mol Genet, 2000 Nov 22. PMID 11092768
  5. Assignment of the centromere protein H (Cenph) gene to mouse chromosome band 13D1 by in situ hybridization and interspecific backcross analyses. Lo AW, et al. Cytogenet Cell Genet, 2000. PMID 11060445

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway.
    Title: CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinetochore binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromosome segregation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in kinetochore assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in kinetochore organization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein H
Names
centromere autoantigen H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399528.1 → NP_001386457.1  centromere protein H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112701
    Conserved Domains (1) summary
    PHA02562
    Location:26 → 155
    46; endonuclease subunit; Provisional

  2. NM_021886.3 → NP_068686.1  centromere protein H isoform 1

    See identical proteins and their annotated locations for NP_068686.1

    Status: VALIDATED

    Source sequence(s)
    AC112701
    Consensus CDS
    CCDS26738.1
    UniProtKB/Swiss-Prot
    Q8R3K9, Q9D079, Q9D0N1, Q9QYM8
    Related
    ENSMUSP00000074988.4, ENSMUST00000075550.4
    Conserved Domains (1) summary
    pfam05837
    Location:134 → 233
    CENP-H; Centromere protein H (CENP-H)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100896187..100912415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247278.2 → XP_030103138.1  centromere protein H isoform X1

    Conserved Domains (2) summary
    PHA02562
    Location:26 → 113
    46; endonuclease subunit; Provisional
    pfam05837
    Location:136 → 157
    CENP-H; Centromere protein H (CENP-H)

  2. XM_030247280.1 → XP_030103140.1  centromere protein H isoform X3

    Conserved Domains (1) summary
    pfam05837
    Location:33 → 142
    CENP-H; Centromere protein H (CENP-H)

  3. XM_006517678.4 → XP_006517741.1  centromere protein H isoform X3

    See identical proteins and their annotated locations for XP_006517741.1

    Conserved Domains (1) summary
    pfam05837
    Location:33 → 142
    CENP-H; Centromere protein H (CENP-H)

  4. XM_036158055.1 → XP_036013948.1  centromere protein H isoform X3

    Conserved Domains (1) summary
    pfam05837
    Location:33 → 142
    CENP-H; Centromere protein H (CENP-H)

  5. XM_036158056.1 → XP_036013949.1  centromere protein H isoform X3

    Conserved Domains (1) summary
    pfam05837
    Location:33 → 142
    CENP-H; Centromere protein H (CENP-H)

RNA

  1. XR_003950454.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYM8.1 GenPept UniProtKB/Swiss-Prot:Q9QYM8

Gene LinkOut

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