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Casp8ap2 caspase 8 associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 26885, updated on 27-Dec-2024

Summary

Official Symbol
Casp8ap2provided by MGI
Official Full Name
caspase 8 associated protein 2provided by MGI
Primary source
MGI:MGI:1349399
See related
Ensembl:ENSMUSG00000028282 AllianceGenome:MGI:1349399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLASH; D4Ertd659e
Summary
Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and positive regulation of cysteine-type endopeptidase activity. Predicted to be located in cytoplasm and nucleus. Predicted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 6.6), placenta adult (RPKM 3.7) and 17 other tissues See more
Orthologs
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Genomic context

See Casp8ap2 in Genome Data Viewer
Location:
4 A5; 4 14.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32615462..32653271)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32615470..32653271)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene BTB and CNC homology, basic leucine zipper transcription factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32647355-32647538 Neighboring gene STARR-seq mESC enhancer starr_09865 Neighboring gene STARR-positive B cell enhancer ABC_E6158 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene gap junction protein, alpha 10 Neighboring gene midasin AAA ATPase 1 Neighboring gene predicted gene, 42267

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • mKIAA1315

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO polymer binding  
enables SUMO polymer binding  
enables cysteine-type endopeptidase activator activity involved in apoptotic process PubMed 
enables identical protein binding PubMed 
enables protease binding PubMed 
enables protein binding PubMed 
enables transcription corepressor activity  
enables transcription corepressor activity  
enables transcription corepressor activity  
Component Evidence Code Pubs
is_active_in PML body  
located_in PML body  
located_in PML body  
located_in cytoplasm  
located_in cytoplasm  
is_active_in mitochondrion  
located_in mitochondrion  
located_in mitochondrion  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
CASP8-associated protein 2
Names
FLICE-associated huge protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122978.2NP_001116450.1  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_001116450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK142148, AL805973, CA526466
    Consensus CDS
    CCDS18016.1
    UniProtKB/Swiss-Prot
    B1AX74, Q9CSW2, Q9WUF3
    Related
    ENSMUSP00000136016.2, ENSMUST00000178925.8
    Conserved Domains (3) summary
    cd12202
    Location:18961960
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10361156
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:75142
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_011997.3NP_036127.2  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_036127.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL805973, AL954737
    Consensus CDS
    CCDS18016.1
    UniProtKB/Swiss-Prot
    B1AX74, Q9CSW2, Q9WUF3
    Related
    ENSMUSP00000029950.4, ENSMUST00000029950.10
    Conserved Domains (3) summary
    cd12202
    Location:18961960
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10361156
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:75142
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32615462..32653271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537949.2XP_006538012.1  CASP8-associated protein 2 isoform X1

    Conserved Domains (3) summary
    cd12202
    Location:19402004
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10801200
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:119186
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_006537950.3XP_006538013.1  CASP8-associated protein 2 isoform X2

    Conserved Domains (3) summary
    cd12202
    Location:19382002
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10781198
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:126184
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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