U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

B3galnt1 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 26879, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
B3galnt1provided by MGI
Official Full Name
UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1provided by MGI
Primary source
MGI:MGI:1349405
See related
Ensembl:ENSMUSG00000043300 AllianceGenome:MGI:1349405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b3GT3; Mbrn 1; B3galt3; b3Gal-T3; beta3GalT3; beta-3-Gx-T3
Summary
Enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 14.0), whole brain E14.5 (RPKM 8.9) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 E1; 3 32.24 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (69481252..69506305, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69573919..69598960, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 (formerly 2C)-like Neighboring gene STARR-positive B cell enhancer ABC_E3437 Neighboring gene STARR-seq mESC enhancer starr_07923 Neighboring gene predicted gene, 52607 Neighboring gene STARR-seq mESC enhancer starr_07924 Neighboring gene STARR-seq mESC enhancer starr_07925 Neighboring gene STARR-seq mESC enhancer starr_07926 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_07927 Neighboring gene STARR-seq mESC enhancer starr_07928 Neighboring gene STARR-seq mESC enhancer starr_07930 Neighboring gene predicted gene, 57714 Neighboring gene ribosomal protein L32, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Vollrath B, et al. Mol Cell Biol, 2001 Aug. PMID 11463849, Free PMC Article
  2. Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products. Fujii Y, et al. Glycobiology, 2005 Dec. PMID 16079416
  3. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. Hennet T, et al. J Biol Chem, 1998 Jan 2. PMID 9417047
  4. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
  5. A genetic approach to Mammalian glycan function. Lowe JB, et al. Annu Rev Biochem, 2003. PMID 12676797

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gb3 and Gb4 synthase are responsible for the expression of globo-series glycolipids
    Title: Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Names
Brainiac 1
Globoside blood group
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase III
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
beta-1,3-GalNAc-T1
beta-1,3-GalTase 3
beta-1,3-galactosyltransferase 3
galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
globoside synthase
NP_001397566.1
NP_001397567.1
NP_064410.1
XP_036019016.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410637.1 → NP_001397566.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC111096
    UniProtKB/Swiss-Prot
    O54906, Q91V72, Q920V0, Q920V1, Q9CTE5

  2. NM_001410638.1 → NP_001397567.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC111096
    UniProtKB/Swiss-Prot
    O54906, Q91V72, Q920V0, Q920V1, Q9CTE5

  3. NM_020026.5 → NP_064410.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_064410.1

    Status: VALIDATED

    Source sequence(s)
    AC111096
    Consensus CDS
    CCDS17406.1
    UniProtKB/Swiss-Prot
    O54906, Q91V72, Q920V0, Q920V1, Q9CTE5
    Related
    ENSMUSP00000058363.2, ENSMUST00000061826.3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    69481252..69506305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163123.1 → XP_036019016.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54906, Q91V72, Q920V0, Q920V1, Q9CTE5
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920V1.2 GenPept UniProtKB/Swiss-Prot:Q920V1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous