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Zswim8 zinc finger SWIM-type containing 8 [ Mus musculus (house mouse) ]

Gene ID: 268721, updated on 21-Apr-2024

Summary

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Official Symbol
Zswim8provided by MGI
Official Full Name
zinc finger SWIM-type containing 8provided by MGI
Primary source
MGI:MGI:1919156
See related
Ensembl:ENSMUSG00000021819 AllianceGenome:MGI:1919156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0913; mKIAA0913; 2310021P13Rik; 4832404P21Rik
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 52.4), adrenal adult (RPKM 48.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 11.53 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20756346..20773687)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20706277..20723619)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6230400D17 gene Neighboring gene predicted gene, 25328 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. Okumura F, et al. Sci Rep, 2021 Oct 22. PMID 34686700, Free PMC Article
  2. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Wang Z, et al. Neuron, 2013 Sep 4. PMID 24012004, Free PMC Article
  3. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi CY, et al. Science, 2020 Dec 18. PMID 33184237, Free PMC Article
  4. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. L'Hôte D, et al. Hum Mol Genet, 2012 Jul 15. PMID 22544055
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development.
    Title: ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of miRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in target-directed miRNA degradation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
zinc finger SWIM domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252081.2 → NP_001239010.1  zinc finger SWIM domain-containing protein 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Consensus CDS
    CCDS88588.1
    UniProtKB/TrEMBL
    B7ZWK9
    Related
    ENSMUSP00000153285.2, ENSMUST00000224751.2
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  2. NM_001252082.2 → NP_001239011.1  zinc finger SWIM domain-containing protein 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Consensus CDS
    CCDS88587.1
    UniProtKB/TrEMBL
    B7ZWK9
    Related
    ENSMUSP00000153027.2, ENSMUST00000223840.2
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  3. NM_001408318.1 → NP_001395247.1  zinc finger SWIM domain-containing protein 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121599

  4. NM_027996.4 → NP_082272.1  zinc finger SWIM domain-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_082272.1

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Consensus CDS
    CCDS36820.1
    UniProtKB/Swiss-Prot
    B2RX90, Q3UHH1, Q5U4B9, Q6PCY6, Q80Y41, Q8CE12, Q8CHC3, Q9D789
    UniProtKB/TrEMBL
    B7ZWK9
    Related
    ENSMUSP00000022358.8, ENSMUST00000022358.9
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20756346..20773687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519034.5 → XP_006519097.1  zinc finger SWIM domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    B7ZWK9
    Conserved Domains (2) summary
    pfam03154
    Location:1491 → 1661
    Atrophin-1; Atrophin-1 family
    pfam03546
    Location:1016 → 1158
    Treacle; Treacher Collins syndrome protein Treacle

  2. XM_006519035.5 → XP_006519098.1  zinc finger SWIM domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    B7ZWK9
    Conserved Domains (2) summary
    pfam03154
    Location:1484 → 1654
    Atrophin-1; Atrophin-1 family
    pfam03546
    Location:1009 → 1151
    Treacle; Treacher Collins syndrome protein Treacle

  3. XM_006519037.5 → XP_006519100.1  zinc finger SWIM domain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    B7ZWK9
    Conserved Domains (2) summary
    pfam03154
    Location:1457 → 1627
    Atrophin-1; Atrophin-1 family
    pfam03546
    Location:982 → 1124
    Treacle; Treacher Collins syndrome protein Treacle

  4. XM_006519039.2 → XP_006519102.1  zinc finger SWIM domain-containing protein 8 isoform X6

    UniProtKB/TrEMBL
    B7ZWK9
    Conserved Domains (2) summary
    pfam03154
    Location:1286 → 1456
    Atrophin-1; Atrophin-1 family
    pfam03546
    Location:811 → 953
    Treacle; Treacher Collins syndrome protein Treacle

  5. XM_006519036.5 → XP_006519099.1  zinc finger SWIM domain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    B7ZWK9
    Conserved Domains (3) summary
    PHA03247
    Location:1529 → 1844
    PHA03247; large tegument protein UL36; Provisional
    pfam03154
    Location:1491 → 1653
    Atrophin-1; Atrophin-1 family
    pfam03546
    Location:1016 → 1158
    Treacle; Treacher Collins syndrome protein Treacle

  6. XM_017316025.1 → XP_017171514.1  zinc finger SWIM domain-containing protein 8 isoform X7

    Conserved Domains (2) summary
    pfam03154
    Location:500 → 670
    Atrophin-1; Atrophin-1 family
    pfam03546
    Location:25 → 167
    Treacle; Treacher Collins syndrome protein Treacle

RNA

  1. XR_003950855.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHH1.1 GenPept UniProtKB/Swiss-Prot:Q3UHH1

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