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Slc38a9 solute carrier family 38, member 9 [ Mus musculus (house mouse) ]

Gene ID: 268706, updated on 11-Apr-2024

Summary

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Official Symbol
Slc38a9provided by MGI
Official Full Name
solute carrier family 38, member 9provided by MGI
Primary source
MGI:MGI:1918839
See related
Ensembl:ENSMUSG00000047789 AllianceGenome:MGI:1918839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730092C09; 4833412L08Rik; 6720411P22Rik; 9130023D20Rik; 9430067K09Rik
Summary
Predicted to enable L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR signaling. Predicted to act upstream of or within amino acid transport. Predicted to be located in late endosome and lysosomal membrane. Predicted to be integral component of lysosomal membrane. Predicted to be part of Ragulator complex. Orthologous to human SLC38A9 (solute carrier family 38 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 7.7), thymus adult (RPKM 4.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D2.2; 13 63.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112792723..112875286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112656189..112738752)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_35695 Neighboring gene DEAD box helicase 4 Neighboring gene STARR-positive B cell enhancer ABC_E10817 Neighboring gene STARR-positive B cell enhancer ABC_E10818 Neighboring gene STARR-positive B cell enhancer ABC_E9889 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113485543-113485843 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene STARR-seq mESC enhancer starr_35698 Neighboring gene STARR-seq mESC enhancer starr_35701 Neighboring gene predicted gene, 41067 Neighboring gene STARR-seq mESC enhancer starr_35702 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet. Hellsten SV, et al. PLoS One, 2017. PMID 28235079, Free PMC Article
  2. Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells. Wang D, et al. Biomolecules, 2021 Sep 6. PMID 34572527, Free PMC Article
  3. mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Wyant GA, et al. Cell, 2017 Oct 19. PMID 29053970, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
    Title: Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
  2. Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins.
    Title: mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
  3. After high-fat diet, Slc38a9 was specifically upregulated in hypothalamus, while overall downregulation was noticed throughout the brain.
    Title: The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-asparagine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol sensor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in asparagine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
  
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neutral amino acid transporter 9
Names
putative sodium-coupled neutral amino acid transporter 9
sodium-coupled neutral amino acid transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178746.4 → NP_848861.1  neutral amino acid transporter 9

    See identical proteins and their annotated locations for NP_848861.1

    Status: VALIDATED

    Source sequence(s)
    AC159242, AK044735, BC052361
    Consensus CDS
    CCDS26775.1
    UniProtKB/Swiss-Prot
    Q80W70, Q8BGD6, Q8C5C3
    Related
    ENSMUSP00000052172.5, ENSMUST00000052514.6
    Conserved Domains (1) summary
    cl00456
    Location:114 → 556
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    112792723..112875286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247276.1 → XP_030103136.1  neutral amino acid transporter 9 isoform X1

    UniProtKB/Swiss-Prot
    Q80W70, Q8BGD6, Q8C5C3
    Conserved Domains (1) summary
    cl00456
    Location:114 → 556
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006517670.4 → XP_006517733.1  neutral amino acid transporter 9 isoform X1

    See identical proteins and their annotated locations for XP_006517733.1

    UniProtKB/Swiss-Prot
    Q80W70, Q8BGD6, Q8C5C3
    Conserved Domains (1) summary
    cl00456
    Location:114 → 556
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_006517671.5 → XP_006517734.1  neutral amino acid transporter 9 isoform X2

    See identical proteins and their annotated locations for XP_006517734.1

    Conserved Domains (1) summary
    cl00456
    Location:107 → 549
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_006517673.5 → XP_006517736.1  neutral amino acid transporter 9 isoform X3

    See identical proteins and their annotated locations for XP_006517736.1

    Conserved Domains (1) summary
    cl00456
    Location:52 → 494
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_017315519.3 → XP_017171008.1  neutral amino acid transporter 9 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:52 → 494
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_036158054.1 → XP_036013947.1  neutral amino acid transporter 9 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:37 → 289
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  7. XM_006517672.3 → XP_006517735.1  neutral amino acid transporter 9 isoform X2

    See identical proteins and their annotated locations for XP_006517735.1

    Conserved Domains (1) summary
    cl00456
    Location:107 → 549
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. XM_006517675.4 → XP_006517738.1  neutral amino acid transporter 9 isoform X3

    See identical proteins and their annotated locations for XP_006517738.1

    Conserved Domains (1) summary
    cl00456
    Location:52 → 494
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_001780783.3 RNA Sequence

  2. XR_003950453.2 RNA Sequence

  3. XR_382737.5 RNA Sequence

  4. XR_873763.4 RNA Sequence

  5. XR_873764.4 RNA Sequence

  6. XR_873762.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175376.2: Suppressed sequence

    Description
    NM_175376.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGD6.1 GenPept UniProtKB/Swiss-Prot:Q8BGD6

Gene LinkOut

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