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Zfp759 zinc finger protein 759 [ Mus musculus (house mouse) ]

Gene ID: 268670, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp759provided by MGI
Official Full Name
zinc finger protein 759provided by MGI
Primary source
MGI:MGI:2446280
See related
Ensembl:ENSMUSG00000057396 AllianceGenome:MGI:2446280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rslcan8; Rslcan-8
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to several human genes including ZNF208 (zinc finger protein 208); ZNF43 (zinc finger protein 43); and ZNF721 (zinc finger protein 721). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 1.3), CNS E18 (RPKM 1.1) and 22 other tissues See more
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Genomic context

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Location:
13 B3; 13 34.54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67273040..67290468)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67121659..67142404)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 708 Neighboring gene uncharacterized LOC118568057 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene regulator of sex-limitation candidate 18 Neighboring gene STARR-positive B cell enhancer ABC_E1465 Neighboring gene STARR-seq mESC enhancer starr_34894 Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1 Neighboring gene protein FAM220A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
  2. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 759
Names
regulator of sex-limitation candidate 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172392.3 → NP_765980.3  zinc finger protein 759

    See identical proteins and their annotated locations for NP_765980.3

    Status: PROVISIONAL

    Source sequence(s)
    BK001631
    Consensus CDS
    CCDS49299.1
    UniProtKB/TrEMBL
    Q7M6X3
    Related
    ENSMUSP00000049650.8, ENSMUST00000052716.8
    Conserved Domains (6) summary
    smart00349
    Location:5 → 63
    KRAB; krueppel associated box
    COG5048
    Location:272 → 713
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:472 → 488
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 44
    KRAB; KRAB box
    pfam13465
    Location:177 → 199
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67273040..67290468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247274.1 → XP_030103134.1  zinc finger protein 759 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:11 → 69
    KRAB; krueppel associated box
    COG5048
    Location:138 → 527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:478 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030247272.2 → XP_030103132.1  zinc finger protein 759 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:31 → 89
    KRAB; krueppel associated box
    COG5048
    Location:158 → 547
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330 → 350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:498 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006517253.5 → XP_006517316.1  zinc finger protein 759 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:31 → 89
    KRAB; krueppel associated box
    COG5048
    Location:158 → 547
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330 → 350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:498 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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