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GGT7 gamma-glutamyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 2686, updated on 3-Apr-2024

Summary

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Official Symbol
GGT7provided by HGNC
Official Full Name
gamma-glutamyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:4259
See related
Ensembl:ENSG00000131067 MIM:612342; AllianceGenome:HGNC:4259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGT4; GGTL3; GGTL5; D20S101
Summary
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.3), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

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See GGT7 in Genome Data Viewer
Location:
20q11.22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (34844720..34872856, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36565362..36593497, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33432523..33460659, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33384717-33385693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33385694-33386669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12848 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33450836-33451387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12851 Neighboring gene acyl-CoA synthetase short chain family member 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:33508643-33509842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17771 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy. Wang X, et al. Oncogene, 2022 Jun. PMID 35662282
  2. [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis]. Samgina TA, et al. Vopr Pitan, 2022. PMID 35596634
  3. Activity determination, kinetic analyses and isoenzyme identification of gamma glutamyltransferase in human neutrophils. Sener A, et al. J Biochem Mol Biol, 2005 May 31. PMID 15943911
  4. A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension. Tan C, et al. Clin Transl Med, 2021 May. PMID 34047475, Free PMC Article
  5. γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth. Bui TT, et al. BMC Cancer, 2015 Apr 7. PMID 25884624, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy.
    Title: Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy.
  2. [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis].
    Title: [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis].
  3. A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension.
    Title: A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension.
  4. Our study demonstrates that GGT7 is a novel player in GBM growth and that GGT7 can play a critical role in tumorigenesis by regulating anti-oxidative damage.
    Title: γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. GGTL3 protein interacts with CT120, a plasma membrane-associated protein possibly involved in lung carcinogenesis.
    Title: Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • dJ18C9.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione hydrolase 7
Names
GGT 7
gamma-glutamyltransferase 4
gamma-glutamyltransferase-like 3
gamma-glutamyltransferase-like 5
gamma-glutamyltranspeptidase 7
gamma-glutamyltranspeptidase-like 3
NP_001338631.1
NP_821158.2
XP_011527084.1
XP_011527085.1
XP_016883300.1
XP_047296063.1
XP_047296064.1
XP_047296065.1
XP_047296066.1
XP_047296067.1
XP_054179331.1
XP_054179332.1
XP_054179333.1
XP_054179334.1
XP_054179335.1
XP_054179336.1
XP_054179337.1
XP_054179338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351702.2 → NP_001338631.1  glutathione hydrolase 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a novel C-terminus and is shorter than isoform 1
    Source sequence(s)
    AL049709
    UniProtKB/TrEMBL
    A4FU32
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 607
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_178026.3 → NP_821158.2  glutathione hydrolase 7 isoform 1

    See identical proteins and their annotated locations for NP_821158.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049709, BC033745, BX401449, DA117929
    Consensus CDS
    CCDS13242.2
    UniProtKB/Swiss-Prot
    Q8N899, Q8NF66, Q9BYP5, Q9BYP6, Q9UJ14
    UniProtKB/TrEMBL
    A5D8W8
    Related
    ENSP00000338964.5, ENST00000336431.10
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 654
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    34844720..34872856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440107.1 → XP_047296063.1  glutathione hydrolase 7 isoform X1

  2. XM_011528782.3 → XP_011527084.1  glutathione hydrolase 7 isoform X7

    Conserved Domains (1) summary
    cl19223
    Location:1 → 420
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. XM_047440111.1 → XP_047296067.1  glutathione hydrolase 7 isoform X6

  4. XM_011528783.4 → XP_011527085.1  glutathione hydrolase 7 isoform X8

    Conserved Domains (1) summary
    cl19223
    Location:1 → 371
    G_glu_transpept; Gamma-glutamyltranspeptidase

  5. XM_047440110.1 → XP_047296066.1  glutathione hydrolase 7 isoform X4

  6. XM_047440109.1 → XP_047296065.1  glutathione hydrolase 7 isoform X3

  7. XM_047440108.1 → XP_047296064.1  glutathione hydrolase 7 isoform X2

  8. XM_017027811.2 → XP_016883300.1  glutathione hydrolase 7 isoform X5

    UniProtKB/TrEMBL
    A0PJJ9
    Conserved Domains (1) summary
    cl19223
    Location:155 → 528
    G_glu_transpept; Gamma-glutamyltranspeptidase

RNA

  1. XR_001754240.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    36565362..36593497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323356.1 → XP_054179331.1  glutathione hydrolase 7 isoform X1

  2. XM_054323362.1 → XP_054179337.1  glutathione hydrolase 7 isoform X7

  3. XM_054323361.1 → XP_054179336.1  glutathione hydrolase 7 isoform X6

  4. XM_054323363.1 → XP_054179338.1  glutathione hydrolase 7 isoform X8

  5. XM_054323359.1 → XP_054179334.1  glutathione hydrolase 7 isoform X4

  6. XM_054323358.1 → XP_054179333.1  glutathione hydrolase 7 isoform X3

  7. XM_054323357.1 → XP_054179332.1  glutathione hydrolase 7 isoform X2

  8. XM_054323360.1 → XP_054179335.1  glutathione hydrolase 7 isoform X5

RNA

  1. XR_008485251.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178025.1: Suppressed sequence

    Description
    NM_178025.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJ14.2 GenPept UniProtKB/Swiss-Prot:Q9UJ14

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