U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Greb1 gene regulated by estrogen in breast cancer protein [ Mus musculus (house mouse) ]

Gene ID: 268527, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Greb1provided by MGI
Official Full Name
gene regulated by estrogen in breast cancer proteinprovided by MGI
Primary source
MGI:MGI:2149712
See related
Ensembl:ENSMUSG00000036523 AllianceGenome:MGI:2149712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0575; 9130004E13; 5730583K22Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; incisor; retina nuclear layer; and tail unsegmented mesenchyme. Orthologous to human GREB1 (growth regulating estrogen receptor binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 76.5), adrenal adult (RPKM 16.0) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 A1.1; 12 8.0 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16720616..16851395, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16670615..16801394, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31639 Neighboring gene lipin 1 Neighboring gene STARR-seq mESC enhancer starr_31643 Neighboring gene STARR-positive B cell enhancer ABC_E11503 Neighboring gene STARR-seq mESC enhancer starr_31645 Neighboring gene neurotensin receptor 2 Neighboring gene STARR-seq mESC enhancer starr_31647 Neighboring gene E2F transcription factor 6 Neighboring gene predicted gene, 36495

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling. Matsumoto S, et al. Nat Commun, 2019 Aug 28. PMID 31462641, Free PMC Article
  2. Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Camden AJ, et al. Mol Hum Reprod, 2017 Sep 1. PMID 28911214, Free PMC Article
  3. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Ghosh MG, et al. Cancer Res, 2000 Nov 15. PMID 11103799
  4. De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness. Schrauwen I, et al. Hum Genet, 2018 Jul. PMID 29955957, Free PMC Article
  5. Genetic, physical, and transcript map of the fld region on mouse chromosome 12. Péterfy M, et al. Genomics, 1999 Dec 15. PMID 10644441

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis.
    Title: A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis.
  2. GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERalpha glycosylation and stability to cancer.
    Title: GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.
  3. Craniofacial Greb1l RNA expression peaks in mice during this time frame (E8.5). It also peaks in the developing inner ear during E13-E16, after which it decreases in adulthood. The crucial function of Greb1l in craniofacial development is also evidenced in knockout mice, which develop severe craniofacial abnormalities
    Title: De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness.
  4. GREB1 is a novel progesterone-responsive gene required for endometrial stromal decidualization.
    Title: Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.
  5. A significant association between GREB1L variants and BKA.
    Title: Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein GREB1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252071.1 → NP_001239000.1  protein GREB1 isoform 2

    See identical proteins and their annotated locations for NP_001239000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC122228, CN536594
    Consensus CDS
    CCDS56830.1
    UniProtKB/TrEMBL
    E0CXG4
    Related
    ENSMUSP00000125339.2, ENSMUST00000159120.8
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1926
    GREB1; Gene regulated by oestrogen in breast cancer

  2. NM_015764.4 → NP_056579.2  protein GREB1 isoform 1

    See identical proteins and their annotated locations for NP_056579.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122228, AC157352, CJ098754, CJ099922, CN536594
    Consensus CDS
    CCDS36408.1
    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Related
    ENSMUSP00000124348.2, ENSMUST00000162112.8
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1954
    GREB1; Gene regulated by oestrogen in breast cancer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    16720616..16851395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515101.5 → XP_006515164.1  protein GREB1 isoform X4

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1858
    GREB1; Gene regulated by oestrogen in breast cancer

  2. XM_006515096.4 → XP_006515159.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515159.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1954
    GREB1; Gene regulated by oestrogen in breast cancer

  3. XM_006515100.4 → XP_006515163.1  protein GREB1 isoform X3

    See identical proteins and their annotated locations for XP_006515163.1

    UniProtKB/TrEMBL
    E0CXG4
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1926
    GREB1; Gene regulated by oestrogen in breast cancer

  4. XM_006515099.4 → XP_006515162.1  protein GREB1 isoform X2

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1953
    GREB1; Gene regulated by oestrogen in breast cancer

  5. XM_006515093.4 → XP_006515156.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515156.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1954
    GREB1; Gene regulated by oestrogen in breast cancer

  6. XM_006515097.3 → XP_006515160.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515160.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1954
    GREB1; Gene regulated by oestrogen in breast cancer

  7. XM_006515094.3 → XP_006515157.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515157.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Related
    ENSMUSP00000044454.10, ENSMUST00000048064.16
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1954
    GREB1; Gene regulated by oestrogen in breast cancer

  8. XM_006515095.3 → XP_006515158.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515158.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1954
    GREB1; Gene regulated by oestrogen in breast cancer

  9. XM_030246728.1 → XP_030102588.1  protein GREB1 isoform X5

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1070
    GREB1; Gene regulated by oestrogen in breast cancer

  10. XM_006515107.4 → XP_006515170.1  protein GREB1 isoform X10

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 612
    GREB1; Gene regulated by oestrogen in breast cancer

  11. XM_006515106.4 → XP_006515169.1  protein GREB1 isoform X9

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 612
    GREB1; Gene regulated by oestrogen in breast cancer

  12. XM_006515105.4 → XP_006515168.1  protein GREB1 isoform X8

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 612
    GREB1; Gene regulated by oestrogen in breast cancer

  13. XM_006515104.4 → XP_006515167.1  protein GREB1 isoform X7

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 750
    GREB1; Gene regulated by oestrogen in breast cancer

  14. XM_006515103.4 → XP_006515166.1  protein GREB1 isoform X6

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 750
    GREB1; Gene regulated by oestrogen in breast cancer

RNA

  1. XR_004937504.1 RNA Sequence

  2. XR_381189.5 RNA Sequence

  3. XR_872413.4 RNA Sequence

  4. XR_381190.4 RNA Sequence

  5. XR_381191.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHK3.2 GenPept UniProtKB/Swiss-Prot:Q3UHK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous