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Mgat5b mannoside acetylglucosaminyltransferase 5, isoenzyme B [ Mus musculus (house mouse) ]

Gene ID: 268510, updated on 5-Mar-2024

Summary

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Official Symbol
Mgat5bprovided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 5, isoenzyme Bprovided by MGI
Primary source
MGI:MGI:3606200
See related
Ensembl:ENSMUSG00000043857 AllianceGenome:MGI:3606200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GnT-IX; mGnTVB; C330018B01
Summary
Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in nervous system and neural ectoderm. Orthologous to human MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 22.3), CNS E18 (RPKM 20.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Mgat5b in Genome Data Viewer
Location:
11 E2; 11 81.49 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116809629..116877770)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116918853..116986944)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene methyltransferase like 23 Neighboring gene jumonji domain containing 6 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene STARR-seq mESC enhancer starr_31229 Neighboring gene STARR-seq mESC enhancer starr_31231 Neighboring gene predicted gene, 33829 Neighboring gene STARR-seq mESC enhancer starr_31232 Neighboring gene STARR-seq mESC enhancer starr_31233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116898528-116898729 Neighboring gene predicted gene 11728 Neighboring gene microRNA 6516 Neighboring gene small nucleolar RNA host gene 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. Kizuka Y, et al. J Biol Chem, 2014 Apr 18. PMID 24619417, Free PMC Article
  2. Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications. Kizuka Y, et al. J Biol Chem, 2011 Sep 9. PMID 21771782, Free PMC Article
  3. Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination. Kanekiyo K, et al. J Neurosci, 2013 Jun 12. PMID 23761899, Free PMC Article
  4. Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V. Lee JK, et al. J Biol Chem, 2012 Aug 17. PMID 22715095, Free PMC Article
  5. N-linked polylactosamine glycan synthesis is regulated by co-expression of β3GnT2 and GCNT2. Henion TR, et al. J Cell Physiol, 2014 Apr. PMID 24105809

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
    Title: Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
  2. a new epigenetic mechanism of brain-specific GnT-IX expression regulated by defined chromatin modifiers, providing new insights into the tissue-specific expression of glycosyltransferases.
    Title: Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers.
  3. This study demonistrated that Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination in animal disease model of Demyelinating Disease in mice.
    Title: Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination.
  4. Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.
    Title: Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.
  5. revealed that the genomic region around the transcriptional start site of the acetylglucosaminyltransferase IX gene was highly associated with active chromatin histone marks in a neural cell-specific manner.
    Title: Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications.
  6. GnT-IX transcripts were restricted to the cerebrum, cerebellum, thymus and testis, whereas GnT-V transcripts were expressed ubiquitously in mouse tissues
    Title: Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
Names
GNT-Vb
N-acetylglucosaminyl-transferase Vb
N-acetylglucosaminyltranferase VB
N-acetylglucosaminyltransferase IX
UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase b
alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B
beta1,6-N-acetylglucosaminyltransferase IX (GnT-IX)
glcNAc-T Vb
mannoside acetylglucosaminyltransferase 5B
NP_766536.2
XP_006533480.1
XP_036012613.1
XP_036012614.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172948.3 → NP_766536.2  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

    See identical proteins and their annotated locations for NP_766536.2

    Status: PROVISIONAL

    Source sequence(s)
    BC094604
    Consensus CDS
    CCDS25682.1
    UniProtKB/Swiss-Prot
    Q765H6, Q8C7T8
    Related
    ENSMUSP00000099316.4, ENSMUST00000103027.10
    Conserved Domains (1) summary
    pfam15024
    Location:184 → 777
    Glyco_transf_18; Glycosyltransferase family 18

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116809629..116877770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533417.5 → XP_006533480.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X2

    Conserved Domains (1) summary
    pfam15024
    Location:147 → 740
    Glyco_transf_18; Glycosyltransferase family 18

  2. XM_036156721.1 → XP_036012614.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X3

    Conserved Domains (1) summary
    pfam15024
    Location:147 → 738
    Glyco_transf_18; Glycosyltransferase family 18

  3. XM_036156720.1 → XP_036012613.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X1

    Conserved Domains (1) summary
    pfam15024
    Location:184 → 775
    Glyco_transf_18; Glycosyltransferase family 18

RNA

  1. XR_388471.4 RNA Sequence

  2. XR_001780011.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q765H6.1 GenPept UniProtKB/Swiss-Prot:Q765H6

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