Meioc meiosis specific with coiled-coil domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meiocprovided by MGI
Official Full Name: meiosis specific with coiled-coil domainprovided by MGI
Primary source: MGI:MGI:2686410
See related: Ensembl:ENSMUSG00000051455 AllianceGenome:MGI:2686410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm663; Gm1564
Summary: Involved in several processes, including gamete generation; germline cell cycle switching, mitotic to meiotic cell cycle; and synaptonemal complex assembly. Located in cytoplasm and nucleus. Is expressed in meiotic germ cell of ovary; ovary; spermatocyte; and testis. Orthologous to human MEIOC (meiosis specific with coiled-coil domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 6.3) and limb E14.5 (RPKM 0.2) See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.48 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102556177..102573066)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102665351..102682240)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that when the meiotic chromosomal program is initiated, Meioc is simultaneously induced so as to extend meiotic prophase. Specifically, MEIOC, together with YTHDC2, promotes a meiotic (as opposed to mitotic) cell cycle program via post-transcriptional control of their target transcripts.
Title: Meioc maintains an extended meiotic prophase I in mice.
Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs.
Title: Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization involved in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis I	IBA Inferred from Biological aspect of Ancestor more info
involved_in female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis I	IBA Inferred from Biological aspect of Ancestor more info
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meiosis-specific coiled-coil domain-containing protein MEIOC

Names: meiosis-specific with coiled-coil domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127576.2 → NP_001121048.1 meiosis-specific coiled-coil domain-containing protein MEIOC

See identical proteins and their annotated locations for NP_001121048.1

Status: VALIDATED

Source sequence(s)

AK131737, AK163979, AL672269, BB610289, BG083749, CJ046726

Consensus CDS

CCDS48945.1

UniProtKB/Swiss-Prot

A2AG06, Q3V2K8

Related

ENSMUSP00000097947.4, ENSMUST00000100378.4

Conserved Domains (1) summary

pfam15189
Location:757 → 922

DUF4582; Domain of unknown function (DUF4582)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

102556177..102573066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533415.2 → XP_006533478.1 meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1

Conserved Domains (1) summary

pfam15189
Location:737 → 902

MEIOC; Meiosis-specific coiled-coil domain-containing protein MEIOC
XM_006533416.3 → XP_006533479.1 meiosis-specific coiled-coil domain-containing protein MEIOC isoform X2

Conserved Domains (1) summary

pfam15189
Location:165 → 330

MEIOC; Meiosis-specific coiled-coil domain-containing protein MEIOC