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Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 [ Mus musculus (house mouse) ]

Gene ID: 268345, updated on 11-Apr-2024

Summary

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Official Symbol
Kcnc2provided by MGI
Official Full Name
potassium voltage gated channel, Shaw-related subfamily, member 2provided by MGI
Primary source
MGI:MGI:96668
See related
Ensembl:ENSMUSG00000035681 AllianceGenome:MGI:96668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv3.2; KShIIIA; B230117I07
Summary
Enables transmembrane transporter binding activity. Acts upstream of or within action potential. Located in several cellular components, including neuronal cell body membrane; perikaryon; and synaptic membrane. Is expressed in eye; genitourinary system; gut; heart; and nervous system. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.9), frontal lobe adult (RPKM 4.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 60.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (112105803..112302209)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (112269898..112466304)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27897 Neighboring gene GLI pathogenesis-related 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_27898 Neighboring gene calcyphosphine 2 Neighboring gene STARR-seq mESC enhancer starr_27899 Neighboring gene STARR-seq mESC enhancer starr_27901 Neighboring gene STARR-seq mESC enhancer starr_27902 Neighboring gene STARR-seq mESC enhancer starr_27903 Neighboring gene STARR-seq mESC enhancer starr_27905 Neighboring gene STARR-seq mESC enhancer starr_27906 Neighboring gene predicted gene, 40764 Neighboring gene RIKEN cDNA 1700010J16 gene Neighboring gene STARR-seq mESC enhancer starr_27907

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired long-range synchronization of gamma oscillations in the neocortex of a mouse lacking Kv3.2 potassium channels. Harvey M, et al. J Neurophysiol, 2012 Aug 1. PMID 22539821, Free PMC Article
  2. Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2. Vyazovskiy VV, et al. Brain Res, 2002 Aug 30. PMID 12176162
  3. Fast delayed rectifier potassium current: critical for input and output of the circadian system. Kudo T, et al. J Neurosci, 2011 Feb 23. PMID 21414897, Free PMC Article
  4. A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina. Ozaita A, et al. J Neurosci, 2004 Aug 18. PMID 15317859, Free PMC Article
  5. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. Lau D, et al. J Neurosci, 2000 Dec 15. PMID 11124984, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although all Kv3 transcripts were significantly expressed in embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins aree present, suggesting a novel role for Kv3 channels at this developmental stage.
    Title: Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.
  2. Mice lacking both Kcnc1 and Kcnc2 genes fail to express the Kv3.1 and Kv3.2 channels in in the suprachiasmatic nucleus.
    Title: Fast delayed rectifier potassium current: critical for input and output of the circadian system.
  3. Kv3.2, Kv1, SK potassium and N-type calcium channels strongly regulate thalamic relay neuron sensory transmission and that each channel subtype controls a different stimulus-response curve property.
    Title: Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels.
  4. Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.2 channel.
    Title: A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina.
  5. Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons.
    Title: Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons.
  6. Kv3.2 expression became detectable in the lumbar cord from postnatal day 12, and increased steadily until reaching an adult level at postnatal day 28. In contrast to the Kv3.1b results, Kv3.2 was not expressed in Renshaw cells.
    Title: Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide-cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in axolemma ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily C member 2
Names
shaw-like potassium channel
voltage-gated potassium channel Kv3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025581.1 → NP_001020752.1  potassium voltage-gated channel subfamily C member 2 isoform 2

    See identical proteins and their annotated locations for NP_001020752.1

    Status: VALIDATED

    Source sequence(s)
    AC121610, AK045425, BB641820
    Consensus CDS
    CCDS24173.1
    UniProtKB/TrEMBL
    A0A1W2P796
    Related
    ENSMUSP00000151579.2, ENSMUST00000219301.2
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  2. NM_001359752.1 → NP_001346681.1  potassium voltage-gated channel subfamily C member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121610, AI835316, BC116289
    Consensus CDS
    CCDS88085.1
    UniProtKB/Swiss-Prot
    Q14B80
    Related
    ENSMUSP00000089814.4, ENSMUST00000092175.4
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  3. NM_001359753.1 → NP_001346682.1  potassium voltage-gated channel subfamily C member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121610, AC153500, AI835316, BC116289
    Consensus CDS
    CCDS88085.1
    UniProtKB/Swiss-Prot
    Q14B80
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  4. NM_001379643.1 → NP_001366572.1  potassium voltage-gated channel subfamily C member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121610, AC153500
    UniProtKB/Swiss-Prot
    Q14B80
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  5. NM_001379644.1 → NP_001366573.1  potassium voltage-gated channel subfamily C member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121610, AC153500
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    112105803..112302209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513693.5 → XP_006513756.1  potassium voltage-gated channel subfamily C member 2 isoform X4

    See identical proteins and their annotated locations for XP_006513756.1

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  2. XM_006513692.4 → XP_006513755.1  potassium voltage-gated channel subfamily C member 2 isoform X4

    See identical proteins and their annotated locations for XP_006513755.1

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  3. XM_006513695.5 → XP_006513758.1  potassium voltage-gated channel subfamily C member 2 isoform X5

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  4. XM_011243455.3 → XP_011241757.1  potassium voltage-gated channel subfamily C member 2 isoform X2

    See identical proteins and their annotated locations for XP_011241757.1

    UniProtKB/TrEMBL
    A0A1W2P796
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  5. XM_006513691.4 → XP_006513754.1  potassium voltage-gated channel subfamily C member 2 isoform X3

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  6. XM_006513694.5 → XP_006513757.1  potassium voltage-gated channel subfamily C member 2 isoform X4

    See identical proteins and their annotated locations for XP_006513757.1

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  7. XM_006513687.5 → XP_006513750.1  potassium voltage-gated channel subfamily C member 2 isoform X1

    See identical proteins and their annotated locations for XP_006513750.1

    UniProtKB/Swiss-Prot
    Q14B80
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  8. XM_006513690.3 → XP_006513753.1  potassium voltage-gated channel subfamily C member 2 isoform X1

    See identical proteins and their annotated locations for XP_006513753.1

    UniProtKB/Swiss-Prot
    Q14B80
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  9. XM_036155791.1 → XP_036011684.1  potassium voltage-gated channel subfamily C member 2 isoform X3

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  10. XM_030245096.1 → XP_030100956.1  potassium voltage-gated channel subfamily C member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q14B80
    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  11. XM_017313951.3 → XP_017169440.1  potassium voltage-gated channel subfamily C member 2 isoform X4

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  12. XM_036155792.1 → XP_036011685.1  potassium voltage-gated channel subfamily C member 2 isoform X4

    Conserved Domains (2) summary
    cd18415
    Location:7 → 170
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:232 → 488
    Ion_trans; Ion transport protein

  13. XM_011243456.4 → XP_011241758.1  potassium voltage-gated channel subfamily C member 2 isoform X6

    Conserved Domains (1) summary
    pfam00520
    Location:31 → 288
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14B80.1 GenPept UniProtKB/Swiss-Prot:Q14B80

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