Rnf217 ring finger protein 217 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf217provided by MGI
Official Full Name: ring finger protein 217provided by MGI
Primary source: MGI:MGI:3610311
See related: Ensembl:ENSMUSG00000063760 AllianceGenome:MGI:3610311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ibrdc1
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in adrenal gland; cerebral cortex mantle layer; and vertebral axis musculature. Orthologous to human RNF217 (ring finger protein 217). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 13.3), adrenal adult (RPKM 9.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 17.45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (31377883..31485721, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (31501887..31609725, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.
Title: RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AI853829 (e-PCR)
- UniSTS:164432

D10Mit155 (e-PCR), detects polymorphism
- UniSTS:126058

15.MMHAP12FLE3.seq (e-PCR)
- UniSTS:123248

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF217

Names: IBR domain containing 1; IBR domain-containing protein 1; probable E3 ubiquitin-protein ligase RNF217

NP_001139821.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146349.1 → NP_001139821.1 E3 ubiquitin-protein ligase RNF217

See identical proteins and their annotated locations for NP_001139821.1

Status: VALIDATED

Source sequence(s)

AC116557, AI853829, BF467827, BG070699, CN459606

Consensus CDS

CCDS48531.1

UniProtKB/Swiss-Prot

D3YYI7

Related

ENSMUSP00000080650.6, ENSMUST00000081989.8

Conserved Domains (3) summary

smart00647
Location:302 → 369

IBR; In Between Ring fingers

pfam01485
Location:397 → 429

IBR; IBR domain, a half RING-finger domain

pfam15327
Location:62 → 131

Tankyrase_bdg_C; Tankyrase binding protein C terminal domain