Dpysl4 dihydropyrimidinase-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpysl4provided by MGI
Official Full Name: dihydropyrimidinase-like 4provided by MGI
Primary source: MGI:MGI:1349764
See related: Ensembl:ENSMUSG00000025478 AllianceGenome:MGI:1349764
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DPY4; Crmp3; Drp-4; Ulip4; CRMP-3
Summary: Enables phosphoprotein binding activity. Predicted to be involved in neuron death and neuron projection guidance. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DPYSL4 (dihydropyrimidinase like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 46.6), CNS E14 (RPKM 41.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 83.92 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (138665917..138681711)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (139085981..139101795)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
Title: Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
Study provides evidence for an animal model for elucidating the roles of collapsin response mediator protein 4 in the development of higher brain functions and developmental regulatory mechanisms controlling the activity of the neural circuitry.
Title: Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb.
Findings suggest that Dpysl4 plays essential roles in tooth germ morphogenesis through the regulation of dental epithelial cell proliferation, cell polarization and differentiation.
Title: Dpysl4 is involved in tooth germ morphogenesis through growth regulation, polarization and differentiation of dental epithelial cells.
CRMP3 protein has HDAC activity. The biological role of nuclear CRMP3 is to mediate nuclear condensation during glutamate-induced excitotoxicity, possibly through up-regulation of E2F1 expression.
Title: Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death.
DPYSL4 is a novel apoptosis-inducible factor controlled by p53 in response to DNA damage
Title: Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.
Data show CRMP3's role in attenuating neurite outgrowth possibility through inhibiting microtubule polymerization, and also reveal its novel association with vimentin during nuclear condensation prior to neuronal death.
Title: Characterization of the role of full-length CRMP3 and its calpain-cleaved product in inhibiting microtubule polymerization and neurite outgrowth.
indicate an important role for CRMP3 in dendrite arborization, guide-posts navigation, and neuronal plasticity
Title: CRMP3 is required for hippocampal CA1 dendritic organization and plasticity.
Collectively, these results reveal a novel role of CRMP-3 in that calpain cleavage of CRMP-3 and the subsequent nuclear translocation of the truncated CRMP-3 evokes neuronal death in response to excitotoxicity and cerebral ischemia.
Title: Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI173505 (e-PCR)
- UniSTS:185740

Dpysl4 (e-PCR), detects polymorphism
- UniSTS:506858

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 4

Names: ULIP-4; UNC33-like phosphoprotein 4; collapsin response mediator protein 3; unc-33-like phosphoprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011993.4 → NP_036123.3 dihydropyrimidinase-related protein 4

See identical proteins and their annotated locations for NP_036123.3

Status: VALIDATED

Source sequence(s)

AI173505, AK165694

Consensus CDS

CCDS21951.1

UniProtKB/Swiss-Prot

O08886, O35098, Q3UL94

UniProtKB/TrEMBL

Q3TMU8

Related

ENSMUSP00000026551.9, ENSMUST00000026551.15

Conserved Domains (1) summary

cd01314
Location:17 → 466

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

138665917..138681711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006536192.4 → XP_006536255.1 dihydropyrimidinase-related protein 4 isoform X1

See identical proteins and their annotated locations for XP_006536255.1

UniProtKB/Swiss-Prot

O08886, O35098, Q3UL94

Conserved Domains (1) summary

cd01314
Location:1 → 403

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
XM_006536193.4 → XP_006536256.1 dihydropyrimidinase-related protein 4 isoform X1

See identical proteins and their annotated locations for XP_006536256.1

UniProtKB/Swiss-Prot

O08886, O35098, Q3UL94

Conserved Domains (1) summary

cd01314
Location:1 → 403

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...