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Cops5 COP9 signalosome subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 26754, updated on 21-Apr-2024

Summary

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Official Symbol
Cops5provided by MGI
Official Full Name
COP9 signalosome subunit 5provided by MGI
Primary source
MGI:MGI:1349415
See related
Ensembl:ENSMUSG00000025917 AllianceGenome:MGI:1349415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSN5; Jab1; Sgn5; Mov34
Summary
Enables enzyme binding activity and macrophage migration inhibitory factor binding activity. Acts upstream of or within regulation of cell cycle. Part of COP9 signalosome. Is expressed in several structures, including 1st branchial arch; central nervous system; cranium; genitourinary system; and sensory organ. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 37.8), placenta adult (RPKM 35.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A2; 1 2.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (10094825..10108384, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (10024600..10038159, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00178 Neighboring gene STARR-seq mESC enhancer starr_00179 Neighboring gene protein phosphatase 1, regulatory subunit 42 Neighboring gene transcription factor 24 Neighboring gene STARR-positive B cell enhancer ABC_E270 Neighboring gene predicted gene, 24674 Neighboring gene STARR-seq mESC enhancer starr_00181 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_00182 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene carboxypeptidase A6 Neighboring gene STARR-seq mESC enhancer starr_00185 Neighboring gene heat shock protein 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice. Huang Q, et al. Endocrinology, 2023 Apr 17. PMID 37067025, Free PMC Article
  2. JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice. Rivellini C, et al. J Clin Invest, 2022 Feb 1. PMID 34874913, Free PMC Article
  3. Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair. Li P, et al. Proc Natl Acad Sci U S A, 2020 Feb 4. PMID 31964807, Free PMC Article
  4. COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis†. Huang Q, et al. Biol Reprod, 2020 Feb 12. PMID 31373619, Free PMC Article
  5. Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway. Cornelius RJ, et al. J Am Soc Nephrol, 2018 Nov. PMID 30301860, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice.
    Title: Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice.
  2. JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice.
    Title: JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice.
  3. The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.
    Title: The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.
  4. COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesisdagger.
    Title: COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis†.
  5. Cops5 KO leads to decreased expression of the pluripotency marker Nanog, proliferation defect, G2/M cell-cycle arrest and apoptosis.
    Title: Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair.
  6. these findings suggested that strategies based on activation of CSN5/LKB1 axis might be promising in the treatment of hypertrophic cardiomyopathy
    Title: CSN5 attenuates Ang II-induced cardiac hypertrophy through stabilizing LKB1.
  7. Asrij sequesters CSN5 via its conserved OCIA domain, thereby preventing p53 degradation.
    Title: Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.
  8. Genetic deletion of Csn5 in Apoe(-/-) mice markedly exacerbated atherosclerotic lesion formation.
    Title: Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.
  9. CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
    Title: Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.
  10. COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
    Title: COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deNEDDylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables macrophage migration inhibitory factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in exosomal secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
COP9 signalosome complex subunit 5
Names
COP9 (constitutive photomorphogenic) homolog, subunit 5
COP9 complex S5
Jun activation domain-binding protein 1
Jun coactivator
Kip1 C-terminus-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277101.1 → NP_001264030.1  COP9 signalosome complex subunit 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102570, AK005728, BC046753, BY393956
    UniProtKB/Swiss-Prot
    O35864
    Conserved Domains (1) summary
    cd08069
    Location:33 → 297
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

  2. NM_013715.2 → NP_038743.1  COP9 signalosome complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_038743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC102570, AK005728, AK012499, BY393956, CX240457
    Consensus CDS
    CCDS14818.1
    UniProtKB/Swiss-Prot
    O35864, Q3UA70, Q8C1S1
    Related
    ENSMUSP00000027050.4, ENSMUST00000027050.10
    Conserved Domains (1) summary
    cd08069
    Location:44 → 314
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

RNA

  1. NR_102282.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC102570, AK005728, BC046753, BY393956, DV056728

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    10094825..10108384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35864.3 GenPept UniProtKB/Swiss-Prot:O35864

Gene LinkOut

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