U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RPS6KC1 ribosomal protein S6 kinase C1 [ Homo sapiens (human) ]

Gene ID: 26750, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
RPS6KC1provided by HGNC
Official Full Name
ribosomal protein S6 kinase C1provided by HGNC
Primary source
HGNC:HGNC:10439
See related
Ensembl:ENSG00000136643 MIM:617517; AllianceGenome:HGNC:10439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSKL1; RPK118; S6PKh1; humS6PKh1; S6K-delta-1
Summary
Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in testis (RPKM 12.3), brain (RPKM 7.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RPS6KC1 in Genome Data Viewer
Location:
1q32.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (213051241..213862735)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (212294330..213102289)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213224583..213448117)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213131647-213132304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213132964-213133621 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:213133682-213134182 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213141040-213141685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2524 Neighboring gene Sharpr-MPRA regulatory region 1741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213188046-213188634 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213188635-213189222 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1809 Neighboring gene vasohibin 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:213231113-213231272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2528 Neighboring gene angel homolog 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:213325631-213326306 Neighboring gene NANOG hESC enhancer GRCh37_chr1:213349583-213350260 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:213393895-213394085 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:213404976-213405900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213454938-213455452 Neighboring gene VISTA enhancer hs1324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213545088-213545614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213545615-213546139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213572574-213573110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213573111-213573646 Neighboring gene MPRA-validated peak692 silencer Neighboring gene VISTA enhancer hs204 Neighboring gene ribosomal protein L31 pseudogene 13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:213680906-213681904 Neighboring gene NANOG hESC enhancer GRCh37_chr1:213685550-213686112 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3904 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:213843687-213844216 Neighboring gene PROX1 antisense RNA 1 Neighboring gene U2 spliceosomal RNA Neighboring gene long intergenic non-protein coding RNA 538

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1. Zhang H, et al. Genomics, 1999 Nov 1. PMID 10552933
  2. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. Hayashi S, et al. J Biol Chem, 2002 Sep 6. PMID 12077123
  3. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Liu L, et al. Mol Cells, 2005 Feb 28. PMID 15750338
  4. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Leparc GG, et al. Nucleic Acids Res, 2007. PMID 17452356, Free PMC Article
  5. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identified as a pseudokinase and named RSKL1
    Title: The protein kinase complement of the human genome.
  2. cloning and characterization of RPK118 as a sphingosine kinase-1-binding protein
    Title: Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein.
  3. findings indicate that RPK118 is a PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking.
    Title: RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosomal protein S6 kinase delta-1
Names
52 kDa ribosomal protein S6 kinase
SPHK1-binding protein
ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
ribosomal protein S6 kinase, 52kDa, polypeptide 1
NP_001129610.1
NP_001274147.1
NP_001274148.1
NP_001274149.1
NP_001274150.1
NP_001336575.1
NP_001336576.1
NP_001336577.1
NP_001336578.1
NP_001336579.1
NP_001336580.1
NP_001336581.1
NP_001336582.1
NP_001336583.1
NP_001336586.1
NP_001336587.1
NP_001336588.1
NP_001336589.1
NP_001336590.1
NP_001336591.1
NP_001336592.1
NP_001336593.1
NP_001336594.1
NP_001336595.1
NP_001336596.1
NP_001336597.1
NP_001336598.1
NP_001336599.1
NP_001336600.1
NP_001336601.1
NP_036556.2
XP_016856513.2
XP_047273868.1
XP_047273875.1
XP_047273889.1
XP_047273892.1
XP_047273895.1
XP_047273896.1
XP_047273901.1
XP_047273904.1
XP_054191956.1
XP_054191957.1
XP_054191958.1
XP_054191959.1
XP_054191960.1
XP_054191961.1
XP_054191962.1
XP_054191963.1
XP_054191964.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136138.4 → NP_001129610.1  ribosomal protein S6 kinase delta-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK122921, AL583826, AL645860, DC323473
    Consensus CDS
    CCDS44317.1
    UniProtKB/TrEMBL
    B4DRK0
    Related
    ENSP00000355926.3, ENST00000366959.4
    Conserved Domains (5) summary
    smart00220
    Location:863 → 1044
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:226 → 300
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:867 → 1044
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl02563
    Location:11 → 116
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:323 → 409
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001287218.3 → NP_001274147.1  ribosomal protein S6 kinase delta-1 isoform c

    See identical proteins and their annotated locations for NP_001274147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 3, 4, and 15 all encode the same isoform (c).
    Source sequence(s)
    AL583826, AL645860, BC143449, DC323473
    Consensus CDS
    CCDS73029.1
    UniProtKB/TrEMBL
    B4DRK0, F5H7T0
    Related
    ENSP00000483873.1, ENST00000614059.4
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:667 → 844
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:134 → 209
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001287219.3 → NP_001274148.1  ribosomal protein S6 kinase delta-1 isoform c

    See identical proteins and their annotated locations for NP_001274148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 3, 4, and 15 all encode the same isoform (c).
    Source sequence(s)
    AK299298, AL512449, AL583826, AL645860, DC323473
    Consensus CDS
    CCDS73029.1
    UniProtKB/TrEMBL
    B4DRK0, F5H7T0
    Related
    ENSP00000442306.1, ENST00000543470.5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:667 → 844
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:134 → 209
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001287220.3 → NP_001274149.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 22-30 all encode the same isoform (d).
    Source sequence(s)
    AL583826, AL645860, BC143473, DC323473
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Related
    ENSP00000484471.1, ENST00000615329.4
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  5. NM_001287221.3 → NP_001274150.1  ribosomal protein S6 kinase delta-1 isoform e

    See identical proteins and their annotated locations for NP_001274150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus, compared to isoform a. Variants 6 and 9-14 all encode the same isoform (e).
    Source sequence(s)
    AL583826, BC143474, DC323473
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Related
    ENSP00000439282.2, ENST00000543354.5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001349646.2 → NP_001336575.1  ribosomal protein S6 kinase delta-1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform f.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (4) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:238 → 312
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:848 → 1025
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:315 → 390
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001349647.2 → NP_001336576.1  ribosomal protein S6 kinase delta-1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes isoform g.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (4) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd05576
    Location:758 → 935
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl00299
    Location:158 → 191
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:214 → 300
    PKc_like; Protein Kinases, catalytic domain

  8. NM_001349648.2 → NP_001336577.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 6 and 10-14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001349649.2 → NP_001336578.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 6, 9, and 11-14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001349650.2 → NP_001336579.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 6, 9, 10, and 12-14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001349651.2 → NP_001336580.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 6, 9-11, 13, and 14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  12. NM_001349652.2 → NP_001336581.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 6, 9-12, and 14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  13. NM_001349653.2 → NP_001336582.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 6 and 9-13, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    B4DRK0, F6RJM5
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698 → 875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154 → 240
    PKc_like; Protein Kinases, catalytic domain

  14. NM_001349654.2 → NP_001336583.1  ribosomal protein S6 kinase delta-1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73029.1
    UniProtKB/TrEMBL
    B4DRK0, F5H7T0
    Conserved Domains (3) summary
    cd02677
    Location:57 → 131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:667 → 844
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:134 → 209
    PKc_like; Protein Kinases, catalytic domain

  15. NM_001349657.2 → NP_001336586.1  ribosomal protein S6 kinase delta-1 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform h.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (2) summary
    cd05576
    Location:582 → 759
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:38 → 124
    PKc_like; Protein Kinases, catalytic domain

  16. NM_001349658.2 → NP_001336587.1  ribosomal protein S6 kinase delta-1 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform h.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (2) summary
    cd05576
    Location:582 → 759
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:38 → 124
    PKc_like; Protein Kinases, catalytic domain

  17. NM_001349659.2 → NP_001336588.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 19-21, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (2) summary
    cd05576
    Location:527 → 704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:1 → 69
    PKc_like; Protein Kinases, catalytic domain

  18. NM_001349660.2 → NP_001336589.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 18, 20, and 21, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (2) summary
    cd05576
    Location:527 → 704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:1 → 69
    PKc_like; Protein Kinases, catalytic domain

  19. NM_001349661.2 → NP_001336590.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 18, 19, and 21, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (2) summary
    cd05576
    Location:527 → 704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:1 → 69
    PKc_like; Protein Kinases, catalytic domain

  20. NM_001349662.2 → NP_001336591.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 18-20, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    UniProtKB/TrEMBL
    B4DRK0
    Conserved Domains (2) summary
    cd05576
    Location:527 → 704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:1 → 69
    PKc_like; Protein Kinases, catalytic domain

  21. NM_001349663.2 → NP_001336592.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 5 and 23-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  22. NM_001349664.2 → NP_001336593.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 5, 22, and 24-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  23. NM_001349665.2 → NP_001336594.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 5, 23, and 25-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  24. NM_001349666.2 → NP_001336595.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 5, 23, 24, and 26-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  25. NM_001349667.2 → NP_001336596.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 5, 23-25, and 27-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  26. NM_001349668.2 → NP_001336597.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 5, 23-26, and 28-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  27. NM_001349669.2 → NP_001336598.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 5, 23-27, 29, and 30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  28. NM_001349670.2 → NP_001336599.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 5, 23-28, and 30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  29. NM_001349671.2 → NP_001336600.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 5 and 23-29, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Conserved Domains (1) summary
    cd05576
    Location:414 → 591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  30. NM_001349672.2 → NP_001336601.1  ribosomal protein S6 kinase delta-1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31) encodes isoform j.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (1) summary
    cl21453
    Location:414 → 561
    PKc_like; Protein Kinases, catalytic domain

  31. NM_012424.6 → NP_036556.2  ribosomal protein S6 kinase delta-1 isoform a

    See identical proteins and their annotated locations for NP_036556.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK122989, AL512449, AL583826, AL645860, DC323473
    Consensus CDS
    CCDS1513.1
    UniProtKB/Swiss-Prot
    B1APS8, B3KVM4, D3DTA4, Q8TDD3, Q96S38, Q9NSF4, Q9UL66
    UniProtKB/TrEMBL
    B4DRK0
    Related
    ENSP00000355927.3, ENST00000366960.8
    Conserved Domains (5) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    smart00220
    Location:875 → 1056
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:238 → 312
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:879 → 1056
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:335 → 421
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_146207.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860

  2. NR_146208.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860

  3. NR_146209.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860

  4. NR_146210.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    213051241..213862735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417936.1 → XP_047273892.1  ribosomal protein S6 kinase delta-1 isoform X5

  2. XM_047417948.1 → XP_047273904.1  ribosomal protein S6 kinase delta-1 isoform X9

    UniProtKB/TrEMBL
    F6RJM5

  3. XM_047417940.1 → XP_047273896.1  ribosomal protein S6 kinase delta-1 isoform X7

  4. XM_047417933.1 → XP_047273889.1  ribosomal protein S6 kinase delta-1 isoform X4

  5. XM_047417939.1 → XP_047273895.1  ribosomal protein S6 kinase delta-1 isoform X6

  6. XM_047417945.1 → XP_047273901.1  ribosomal protein S6 kinase delta-1 isoform X8

  7. XM_017001024.2 → XP_016856513.2  ribosomal protein S6 kinase delta-1 isoform X3

  8. XM_047417912.1 → XP_047273868.1  ribosomal protein S6 kinase delta-1 isoform X1

  9. XM_047417919.1 → XP_047273875.1  ribosomal protein S6 kinase delta-1 isoform X2

RNA

  1. XR_007058661.1 RNA Sequence

  2. XR_007058662.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    212294330..213102289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335985.1 → XP_054191960.1  ribosomal protein S6 kinase delta-1 isoform X5

  2. XM_054335989.1 → XP_054191964.1  ribosomal protein S6 kinase delta-1 isoform X9

    UniProtKB/TrEMBL
    F6RJM5

  3. XM_054335987.1 → XP_054191962.1  ribosomal protein S6 kinase delta-1 isoform X7

  4. XM_054335984.1 → XP_054191959.1  ribosomal protein S6 kinase delta-1 isoform X4

  5. XM_054335986.1 → XP_054191961.1  ribosomal protein S6 kinase delta-1 isoform X6

  6. XM_054335988.1 → XP_054191963.1  ribosomal protein S6 kinase delta-1 isoform X8

  7. XM_054335983.1 → XP_054191958.1  ribosomal protein S6 kinase delta-1 isoform X3

  8. XM_054335981.1 → XP_054191956.1  ribosomal protein S6 kinase delta-1 isoform X1

  9. XM_054335982.1 → XP_054191957.1  ribosomal protein S6 kinase delta-1 isoform X2

RNA

  1. XR_008485992.1 RNA Sequence

  2. XR_008485993.1 RNA Sequence

  3. XR_008485994.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96S38.2 GenPept UniProtKB/Swiss-Prot:Q96S38

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous