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Mill1 MHC I like leukocyte 1 [ Mus musculus (house mouse) ]

Gene ID: 266815, updated on 8-Feb-2024

Summary

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Official Symbol
Mill1provided by MGI
Official Full Name
MHC I like leukocyte 1provided by MGI
Primary source
MGI:MGI:2179988
See related
Ensembl:ENSMUSG00000054005 AllianceGenome:MGI:2179988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5530400I18Rik
Summary
Predicted to be involved in immune response. Is anchored component of external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7 A2; 7 9.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (17979150..18000017)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18245225..18266092)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18163 Neighboring gene IGF-like family member 3 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18167 Neighboring gene pregnancy specific beta-1-glycoprotein 18 Neighboring gene STARR-seq mESC enhancer starr_18168 Neighboring gene myotubularin related protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing. Rabinovich BA, et al. Immunol Cell Biol, 2008 Aug-Sep. PMID 18560379
  2. Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma. Ritter C, et al. Sci Rep, 2016 Feb 23. PMID 26902929, Free PMC Article
  3. MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression. Kajikawa M, et al. J Immunol, 2006 Sep 1. PMID 16920948
  4. Recognition of the ligand-type specificity of classical and non-classical MHC I proteins. Martínez-Naves E, et al. FEBS Lett, 2011 Nov 4. PMID 22001201
  5. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Kasahara M, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370446, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reversal of epigenetic silencing of MICA and MICB improves immune recognition and killing of Merkel cell carcinoma cells.
    Title: Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.
  2. Our results suggest a role for the Mill proteins in cellular metabolism, with possible therapeutic significance.
    Title: A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing.
  3. Mill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains.
    Title: A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.
  4. two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m)
    Title: MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC129328, MGC129329

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MHC class I-like protein MILL1
Names
MHC class I-like located near the leukocyte receptor complex 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153749.4 → NP_715630.3  MHC class I-like protein MILL1 precursor

    See identical proteins and their annotated locations for NP_715630.3

    Status: VALIDATED

    Source sequence(s)
    AC151983, AK029010
    Consensus CDS
    CCDS20868.1
    UniProtKB/Swiss-Prot
    Q8HWA4, Q8HWA5, Q8HWE7
    Related
    ENSMUSP00000069083.5, ENSMUST00000066780.5
    Conserved Domains (3) summary
    cd00096
    Location:242 → 248
    Ig; Ig strand A [structural motif]
    cl08246
    Location:60 → 229
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:242 → 323
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    17979150..18000017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540014.2 → XP_006540077.1  MHC class I-like protein MILL1 isoform X2

    Conserved Domains (1) summary
    cl08246
    Location:61 → 130
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. XM_006540013.2 → XP_006540076.1  MHC class I-like protein MILL1 isoform X1

    See identical proteins and their annotated locations for XP_006540076.1

    Conserved Domains (2) summary
    cl08246
    Location:2 → 161
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:174 → 255
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HWE7.1 GenPept UniProtKB/Swiss-Prot:Q8HWE7

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