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Tbkbp1 TBK1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266764, updated on 5-Mar-2024

Summary

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Official Symbol
Tbkbp1provided by RGD
Official Full Name
TBK1 binding protein 1provided by RGD
Primary source
RGD:631328
See related
Ensembl:ENSRNOG00000009370 AllianceGenome:RGD:631328
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prosapip2
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to be active in cytoplasm. Orthologous to human TBKBP1 (TBK1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 32.3), Lung (RPKM 31.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbkbp1 in Genome Data Viewer
Location:
10q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82616978..82632169, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82120558..82135749, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85071058..85085596, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 7 Neighboring gene T-box transcription factor 21 Neighboring gene karyopherin subunit beta 1 Neighboring gene aminopeptidase puromycin sensitive Neighboring gene uncharacterized LOC134480862

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Liebau S, et al. Biochem Biophys Res Commun, 2009 Jul 31. PMID 19481056
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TANK-binding kinase 1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172021.2 → NP_742018.2  TANK-binding kinase 1-binding protein 1

    See identical proteins and their annotated locations for NP_742018.2

    Status: PROVISIONAL

    Source sequence(s)
    BC076503
    UniProtKB/Swiss-Prot
    Q6DG50, Q8K1Q5
    UniProtKB/TrEMBL
    A6HIJ3
    Related
    ENSRNOP00000012461.4, ENSRNOT00000012462.5
    Conserved Domains (2) summary
    TIGR02168
    Location:50 → 333
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:289 → 342
    TBD; TBD domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82616978..82632169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085315.1 → XP_038941243.1  TANK-binding kinase 1-binding protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q6DG50, Q8K1Q5
    UniProtKB/TrEMBL
    A6HIJ3
    Conserved Domains (2) summary
    TIGR02168
    Location:50 → 333
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:289 → 342
    TBD; TBD domain

  2. XM_063268494.1 → XP_063124564.1  TANK-binding kinase 1-binding protein 1 isoform X1

  3. XM_063268495.1 → XP_063124565.1  TANK-binding kinase 1-binding protein 1 isoform X1

  4. XM_063268496.1 → XP_063124566.1  TANK-binding kinase 1-binding protein 1 isoform X2

  5. XM_063268493.1 → XP_063124563.1  TANK-binding kinase 1-binding protein 1 isoform X1

  6. XM_039085316.2 → XP_038941244.1  TANK-binding kinase 1-binding protein 1 isoform X4

    Conserved Domains (2) summary
    TIGR02168
    Location:53 → 340
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:288 → 341
    TBD; TBD domain

  7. XM_063268497.1 → XP_063124567.1  TANK-binding kinase 1-binding protein 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DG50.1 GenPept UniProtKB/Swiss-Prot:Q6DG50

Gene LinkOut

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