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MYEOV myeloma overexpressed [ Homo sapiens (human) ]

Gene ID: 26579, updated on 3-Apr-2024

Summary

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Official Symbol
MYEOVprovided by HGNC
Official Full Name
myeloma overexpressedprovided by HGNC
Primary source
HGNC:HGNC:7563
See related
Ensembl:ENSG00000172927 MIM:605625; AllianceGenome:HGNC:7563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCIM
Expression
Biased expression in stomach (RPKM 11.5), esophagus (RPKM 10.9) and 5 other tissues See more
Orthologs
all
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Genomic context

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Location:
11q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69294155..69297287)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69311284..69314452)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69061622..69064754)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369367 Neighboring gene uncharacterized LOC105369368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5154 Neighboring gene VISTA enhancer hs2073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69060193-69060744 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:69064594-69065793 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69066990-69067178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69078345-69078844 Neighboring gene interferon induced transmembrane protein 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69088091-69088958 Neighboring gene uncharacterized LOC105369370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69153613-69154114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69154115-69154614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69157262-69158194 Neighboring gene MPRA-validated peak1324 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway. Tange S, et al. BMC Cancer, 2023 Jan 25. PMID 36698109, Free PMC Article
  2. The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma. Shen H, et al. Cell Death Dis, 2021 Dec 20. PMID 34930894, Free PMC Article
  3. High expression of MYEOV reflects poor prognosis in non-small cell lung cancer. Zhang R, et al. Gene, 2021 Feb 20. PMID 33278551
  4. Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma. Tang R, et al. Cell Cycle, 2020 Jul. PMID 32420813, Free PMC Article
  5. MYEOV is a prognostic factor in multiple myeloma. Moreaux J, et al. Exp Hematol, 2010 Dec. PMID 20854874

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway.
    Title: MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway.
  2. The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma.
    Title: The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma.
  3. Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma.
    Title: Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma.
  4. High expression of MYEOV reflects poor prognosis in non-small cell lung cancer.
    Title: High expression of MYEOV reflects poor prognosis in non-small cell lung cancer.
  5. MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity.
    Title: MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity.
  6. experiments demonstrated that the MYEOV ceRNA sequestered miR-30c-2-3p from binding its targets TGFBR2 and USP15 mRNAs, which in turn leading to constitutive activation of TGF-beta signaling and tumor progression in Non-small cell lung cancer.
    Title: MYEOV functions as an amplified competing endogenous RNA in promoting metastasis by activating TGF-β pathway in NSCLC.
  7. The results of these studies provide supporting evidence for MYEOV and NEGR1 as gene targets of 11q13 gains and 1p31 deletions in a neuroblastoma subset.
    Title: Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.
  8. MYEOV expression is a prognostic factor for patients with multiple myeloma, in part through a role of MYEOV in the control of MMC proliferation.
    Title: MYEOV is a prognostic factor in multiple myeloma.
  9. High MYEOV is associated with colon cancer cell migration.
    Title: MYEOV (myeloma overexpressed gene) drives colon cancer cell migration and is regulated by PGE2.
  10. Both myeov and hst (fgf4) are normally situated approximately 475-kb apart at band 11q13, a region that is frequently amplified and overexpressed in various tumours.
    Title: Rearrangement and expression of myeov and hst in NIH/3T3 transfectants: a caveat for the interpretation of DNA transfection analyses.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan for variants associated with early-onset prostate cancer.
EBI GWAS Catalog
Genome-wide association study identifies five new breast cancer susceptibility loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
myeloma-overexpressed gene protein
Names
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)
oncogene in multiple myeloma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293291.2 → NP_001280220.1  myeloma-overexpressed gene protein isoform 1

    See identical proteins and their annotated locations for NP_001280220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS8190.1
    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
    UniProtKB/TrEMBL
    A8K256
    Related
    ENSP00000412482.2, ENST00000441339.3

  2. NM_001293294.2 → NP_001280223.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001280223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal splice junction, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AJ223366, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3
    Related
    ENST00000535653.1

  3. NM_001293296.2 → NP_001280225.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001280225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the 5' UTR, which results in translation initiation at a downstream AUG start codon, and it also lacks an internal splice junction, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3
    Related
    ENSP00000438100.1, ENST00000535407.1

  4. NM_001300923.2 → NP_001287852.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001287852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813, DA377031
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3

  5. NM_001300924.2 → NP_001287853.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001287853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813, DA902417
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3

  6. NM_138768.4 → NP_620123.2  myeloma-overexpressed gene protein isoform 1

    See identical proteins and their annotated locations for NP_620123.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AJ223366, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS8190.1
    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
    UniProtKB/TrEMBL
    A8K256
    Related
    ENSP00000308330.3, ENST00000308946.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69294155..69297287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426763.1 → XP_047282719.1  myeloma-overexpressed gene protein isoform X1

    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69311284..69314452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368411.1 → XP_054224386.1  myeloma-overexpressed gene protein isoform X1

    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EZ4.2 GenPept UniProtKB/Swiss-Prot:Q96EZ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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