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Cops3 COP9 signalosome subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 26572, updated on 5-Mar-2024

Summary

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Official Symbol
Cops3provided by MGI
Official Full Name
COP9 signalosome subunit 3provided by MGI
Primary source
MGI:MGI:1349409
See related
Ensembl:ENSMUSG00000019373 AllianceGenome:MGI:1349409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csn3; Sgn3
Summary
Acts upstream of or within in utero embryonic development. Part of COP9 signalosome. Is expressed in several structures, including inner cell mass; reproductive system; skeletal muscle tissue; spleen; and urinary system. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.5), CNS E14 (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cops3 in Genome Data Viewer
Location:
11 B1.3; 11 37.8 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59708621..59739080, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59817795..59848245, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phospholipase D family member 6 Neighboring gene folliculin Neighboring gene STARR-seq mESC enhancer starr_29631 Neighboring gene predicted gene 16062 Neighboring gene predicted gene, 51946 Neighboring gene STARR-positive B cell enhancer ABC_E5233 Neighboring gene STARR-positive B cell enhancer ABC_E2354 Neighboring gene 5',3'-nucleotidase, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_29632 Neighboring gene STARR-positive B cell enhancer ABC_E6991 Neighboring gene RIKEN cDNA 1810063I02 gene Neighboring gene predicted gene, 51900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype. He ZZ, et al. Cell Signal, 2022 Jul. PMID 35491006
  2. The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes. Israel S, et al. Mol Hum Reprod, 2021 Aug 7. PMID 34264319
  3. Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway. Ba MA, et al. BMC Pharmacol Toxicol, 2017 Jun 17. PMID 28623958, Free PMC Article
  4. Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation. Kim E, et al. PLoS One, 2011. PMID 21991377, Free PMC Article
  5. COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Yan J, et al. Mol Cell Biol, 2003 Oct. PMID 12972600, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
    Title: The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
  2. COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype.
    Title: COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype.
  3. The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes.
    Title: The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes.
  4. This is the first study toward understanding the role of the CSN3 in skeletal muscle differentiation and proliferation. Our results show that knockdown of CSN3 in C2C12 cells leads to impaired differentiation, proliferation and cell cycle regulation of myoblasts.
    Title: Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway.
  5. CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
    Title: Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.
  6. Cops3 encodes the third subunit of the COP9 signalosome, which controls a wide vasriety of molecules of different functions.
    Title: COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 3
Names
COP9 (constitutive photomorphogenic) homolog, subunit 3
COP9 (constitutive photomorphogenic), subunit 3
COP9 complex S3
JAB1-containing signalosome subunit 3
signalosome subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417566.1 → NP_001404495.1  COP9 signalosome complex subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068808

  2. NM_011991.2 → NP_036121.1  COP9 signalosome complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_036121.1

    Status: VALIDATED

    Source sequence(s)
    AC068808
    Consensus CDS
    CCDS24778.1
    UniProtKB/Swiss-Prot
    O88543
    UniProtKB/TrEMBL
    Q3UQL2
    Related
    ENSMUSP00000019517.4, ENSMUST00000019517.10
    Conserved Domains (1) summary
    pfam01399
    Location:259 → 362
    PCI; PCI domain

RNA

  1. NR_184531.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  2. NR_184532.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  3. NR_184533.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  4. NR_184534.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

  5. NR_184535.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59708621..59739080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246025.1 → XP_030101885.1  COP9 signalosome complex subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam01399
    Location:239 → 342
    PCI; PCI domain

  2. XM_036156712.1 → XP_036012605.1  COP9 signalosome complex subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam01399
    Location:239 → 342
    PCI; PCI domain

RNA

  1. XR_003949446.1 RNA Sequence

  2. XR_004936968.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88543.3 GenPept UniProtKB/Swiss-Prot:O88543

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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