Ror1 receptor tyrosine kinase-like orphan receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ror1provided by MGI
Official Full Name: receptor tyrosine kinase-like orphan receptor 1provided by MGI
Primary source: MGI:MGI:1347520
See related: Ensembl:ENSMUSG00000035305 AllianceGenome:MGI:1347520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ntrkr1; 2810404D04Rik
Summary: This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression: Broad expression in bladder adult (RPKM 2.2), limb E14.5 (RPKM 1.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.71 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (99952988..100302003)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (100095791..100444806)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-kappaB signaling pathway.
Title: ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression.
Title: Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression.
Ror1 promotes PPARalpha-mediated fatty acid metabolism in astrocytes.
Title: Ror1 promotes PPARα-mediated fatty acid metabolism in astrocytes.
The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.
Title: The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.
Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1alpha regulator.
Title: Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.
WNT5a-ROR Signaling Is Essential for Alveologenesis.
Title: WNT5a-ROR Signaling Is Essential for Alveologenesis.
ROR1 is expressed in hepatocellular carcinoma and contributes to disease development.
Title: ROR1 Expression and Its Functional Significance in Hepatocellular Carcinoma Cells.
ROR1 was one of the most significantly regulated receptor tyrosine kinases in the ischemic heart and may be a potential target for the treatment of ischemic heart injury.
Title: Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target.
ROR1 is a targeted gene of Twist. Twist/ROR1 signaling is critical for invasion and metastasis in breast cancer.
Title: Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1.
Ror1 genetically interacts with Wnt9a. Ror1hyp/hyp;Wnt9a-/- double mutants displayed a secondary palate cleft phenotype and shorter long bones.
Title: Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

01.MMHAP71FRA7.seq (e-PCR)
- UniSTS:122671

Ror1 (e-PCR), detects polymorphism
- UniSTS:507194

D4Mit175 (e-PCR), detects polymorphism
- UniSTS:129954

NoName (e-PCR)
- UniSTS:234976

NoName (e-PCR)
- UniSTS:234978

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in astrocyte development	ISO Inferred from Sequence Orthology more info
NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive tyrosine-protein kinase transmembrane receptor ROR1

Names: neurotrophic tyrosine kinase, receptor-related 1; tyrosine-protein kinase transmembrane receptor ROR1

NP_001299619.1

EC 2.7.10.1

NP_038873.2

EC 2.7.10.1

XP_006503184.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001312690.1 → NP_001299619.1 inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in an early stop codon and a novel 3' UTR compared to variant 1. The encoded isoform (2) has a shorter C-terminus than isoform 1.

Source sequence(s)

AK049369, AL670246, BB652069

UniProtKB/TrEMBL

Q501P6

Conserved Domains (2) summary

smart00408
Location:72 → 137

IGc2; Immunoglobulin C-2 Type

pfam07679
Location:63 → 148

I-set; Immunoglobulin I-set domain
NM_013845.5 → NP_038873.2 inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

See identical proteins and their annotated locations for NP_038873.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK049369, AL670246, BB652069

Consensus CDS

CCDS18389.1

UniProtKB/Swiss-Prot

Q8BG10, Q9Z139

UniProtKB/TrEMBL

Q8BNP9

Related

ENSMUSP00000048171.6, ENSMUST00000039630.6

Conserved Domains (6) summary

cd00096
Location:75 → 143

Ig; Immunoglobulin domain

cd07467
Location:166 → 307

CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1

smart00130
Location:311 → 393

KR; Kringle domain

pfam07679
Location:63 → 148

I-set; Immunoglobulin I-set domain

cd05090
Location:467 → 749

PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

pfam07714
Location:473 → 746

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

99952988..100302003

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503121.2 → XP_006503184.1 inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

Conserved Domains (3) summary

smart00130
Location:123 → 205

KR; Kringle domain

cd05090
Location:279 → 561

PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

cl02447
Location:1 → 119

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain