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Zfp260 zinc finger protein 260 [ Mus musculus (house mouse) ]

Gene ID: 26466, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp260provided by MGI
Official Full Name
zinc finger protein 260provided by MGI
Primary source
MGI:MGI:1347071
See related
Ensembl:ENSMUSG00000049421 AllianceGenome:MGI:1347071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEX1; Ozrf1; Zfp63; Znf260
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut epithelium; and heart. Orthologous to human ZNF260 (zinc finger protein 260). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.5), limb E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 17.26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29794207..29807047)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30094782..30107622)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 82 Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869 Neighboring gene STARR-seq mESC enhancer starr_18505 Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 334 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling. Komati H, et al. J Biol Chem, 2011 Jan 14. PMID 21051538, Free PMC Article
  2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. Blottière L, et al. Cytogenet Cell Genet, 1999. PMID 10449921
  3. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Debrus S, et al. Mol Cell Biol, 2005 Oct. PMID 16166646, Free PMC Article
  4. Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene. Altomare DA, et al. Cytogenet Cell Genet, 1996. PMID 8976376
  5. Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Danciger M, et al. Genomics, 1995 Jul 1. PMID 7590745

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. pex1 is a novel nuclear effector of ET-1 signaling and may be a regulator of the early stages of cardiac hypertrophy
    Title: ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 260
Names
zfp-260

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011981.4 → NP_036111.2  zinc finger protein 260

    See identical proteins and their annotated locations for NP_036111.2

    Status: VALIDATED

    Source sequence(s)
    BC085180
    Consensus CDS
    CCDS21078.1
    UniProtKB/Swiss-Prot
    Q3U170, Q62513, Q8C2Q6, Q9R2B4
    Related
    ENSMUSP00000052200.6, ENSMUST00000050735.12
    Conserved Domains (2) summary
    COG5048
    Location:22 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:329 → 349
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29794207..29807047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250583.1 → XP_011248885.1  zinc finger protein 260 isoform X1

    See identical proteins and their annotated locations for XP_011248885.1

    UniProtKB/Swiss-Prot
    Q3U170, Q62513, Q8C2Q6, Q9R2B4
    Conserved Domains (2) summary
    COG5048
    Location:22 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:329 → 349
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011250584.4 → XP_011248886.1  zinc finger protein 260 isoform X1

    See identical proteins and their annotated locations for XP_011248886.1

    UniProtKB/Swiss-Prot
    Q3U170, Q62513, Q8C2Q6, Q9R2B4
    Conserved Domains (2) summary
    COG5048
    Location:22 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:329 → 349
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62513.1 GenPept UniProtKB/Swiss-Prot:Q62513

Gene LinkOut

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