Vnn3 vanin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vnn3provided by MGI
Official Full Name: vanin 3provided by MGI
Primary source: MGI:MGI:1347055
See related: Ensembl:ENSMUSG00000020010 AllianceGenome:MGI:1347055
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables pantetheine hydrolase activity. Involved in pantothenate metabolic process. Located in extracellular space. Is expressed in early conceptus. Orthologous to human VNN3P (vanin 3, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 44.4), liver adult (RPKM 22.2) and 4 other tissues See more
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Genomic context

Location:: 10 A4; 10 11.24 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23727360..23745741)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23851462..23869843)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of pantetheinase protein activity in tissues is associated with susceptibility to malaria and is linked to a complex rearrangement in the Vnn3 promoter region.
Title: Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Markers

Vnn3 (e-PCR), detects polymorphism
- UniSTS:472923

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info
enables pantetheine hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantetheine hydrolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in nitrogen compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pantothenate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular non-inflammatory molecule 3

NP_036109.3

EC 3.5.1.92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011979.2 → NP_036109.3 vascular non-inflammatory molecule 3 precursor

See identical proteins and their annotated locations for NP_036109.3

Status: VALIDATED

Source sequence(s)

AC153973

Consensus CDS

CCDS23734.1

UniProtKB/Swiss-Prot

E9QMT9, Q9QZ25

UniProtKB/TrEMBL

Q2T9H5

Related

ENSMUSP00000020190.8, ENSMUST00000020190.8

Conserved Domains (1) summary

cd07567
Location:26 → 329

biotinidase_like; biotinidase and vanins (class 4 nitrilases)