Nbea neurobeachin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nbeaprovided by MGI
Official Full Name: neurobeachinprovided by MGI
Primary source: MGI:MGI:1347075
See related: Ensembl:ENSMUSG00000027799 AllianceGenome:MGI:1347075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyst2; mKIAA1544
Summary: Enables protein kinase binding activity. Acts upstream of or within hematopoietic stem cell homeostasis and protein localization. Located in several cellular components, including cytosol; nucleus; and trans-Golgi network. Is expressed in several structures, including brain; branchial arch; neural tube; sensory organ; and somite. Used to study autism spectrum disorder. Orthologous to human NBEA (neurobeachin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 19.0), whole brain E14.5 (RPKM 15.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 26.61 cM

Exon count:: 66

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (55532616..56091169, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (55625195..56183748, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning.
Title: Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning.
Nbea heterozygotes showed normal fear acquisition and fear memory recall but showed impairment in extinction. Our data suggest that NBEA is necessary either for induction of memory lability or for the physiological process of memory extinction
Title: The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory.
KIF21B constrains NBEA dynamics and is present in the NBEA-recycling endosome-NMDA receptor complex.
Title: Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.
Nbea targets glutamate and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.
Title: Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.
The physical interaction of NBEA with NOTCH1 is most relevant for autism spectrum disorders pathogenesis because NOTCH signaling is essential for neural development.
Title: Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription.
These findings indicate that Nbea haploinsufficiency leads to various molecular and cellular changes that affect neuroplasticity and behavioral functions in mice
Title: Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice.
Nbea regulates synaptic transmission under basal conditions by targeting neurotransmitter receptors to synapses.
Title: Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.
Title: Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.
data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits
Title: Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
Data show that deletion of Nbea leads to reduced numbers of spinous synapses in cultured neurons from complete knockouts and in cortical tissue from heterozygous mice, accompanied by altered miniature postsynaptic currents.
Title: Dendritic spine formation and synaptic function require neurobeachin.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Gene trapped (1)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Dcr4 (e-PCR), detects polymorphism
- UniSTS:507676

D3Dcr5 (e-PCR), detects polymorphism
- UniSTS:507677

Nbea (e-PCR), detects polymorphism
- UniSTS:507954

Nbea (e-PCR), detects polymorphism
- UniSTS:507955

Nbea (e-PCR), detects polymorphism
- UniSTS:507956

Nbea (e-PCR), detects polymorphism
- UniSTS:528240

BB247703 (e-PCR)
- UniSTS:207486

AW047968 (e-PCR)
- UniSTS:165254

MHAa21b3.seq (e-PCR)
- UniSTS:125077

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase A binding	NAS Non-traceable Author Statement more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-Golgi vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein targeting	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neurobeachin

Names: lysosomal trafficking regulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030595.1 → NP_085098.1 neurobeachin

See identical proteins and their annotated locations for NP_085098.1

Status: VALIDATED

Source sequence(s)

AC121842, AC138738, AC162280, BC034103, Y18276

Consensus CDS

CCDS50911.1

UniProtKB/Swiss-Prot

Q8C931, Q9EPM9, Q9EPN0, Q9EPN1, Q9WVM9

Related

ENSMUSP00000029374.7, ENSMUST00000029374.8

Conserved Domains (8) summary

COG2319
Location:2625 → 2924

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2277 → 2553

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2148 → 2245

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2714 → 2768

7WD40; WD40 repeat [structural motif]

cl02567
Location:2667 → 2924

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

55532616..56091169 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163118.1 → XP_036019011.1 neurobeachin isoform X14

Conserved Domains (7) summary

sd00039
Location:2705 → 2759

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2268 → 2544

Beach; Beige/BEACH domain

pfam06469
Location:1947 → 2113

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2139 → 2236

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2658 → 2915

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163115.1 → XP_036019008.1 neurobeachin isoform X5

Conserved Domains (7) summary

sd00039
Location:2737 → 2791

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2279 → 2576

Beach; Beige/BEACH domain

pfam06469
Location:1947 → 2113

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2150 → 2247

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2690 → 2947

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017319586.2 → XP_017175075.1 neurobeachin isoform X11

Conserved Domains (7) summary

sd00039
Location:2711 → 2765

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2274 → 2550

Beach; Beige/BEACH domain

pfam06469
Location:1953 → 2119

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2145 → 2242

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2664 → 2921

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006501520.4 → XP_006501583.1 neurobeachin isoform X7

Conserved Domains (7) summary

sd00039
Location:2732 → 2786

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2274 → 2571

Beach; Beige/BEACH domain

pfam06469
Location:1953 → 2119

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2145 → 2242

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2685 → 2942

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163112.1 → XP_036019005.1 neurobeachin isoform X2

Conserved Domains (7) summary

sd00039
Location:2743 → 2797

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2285 → 2582

Beach; Beige/BEACH domain

pfam06469
Location:1953 → 2119

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2156 → 2253

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2696 → 2953

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017319587.2 → XP_017175076.1 neurobeachin isoform X13

Conserved Domains (7) summary

sd00039
Location:2708 → 2762

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2271 → 2547

Beach; Beige/BEACH domain

pfam06469
Location:1950 → 2116

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2142 → 2239

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2661 → 2918

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006501522.4 → XP_006501585.1 neurobeachin isoform X8

Conserved Domains (7) summary

sd00039
Location:2729 → 2783

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2271 → 2568

Beach; Beige/BEACH domain

pfam06469
Location:1950 → 2116

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2142 → 2239

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2682 → 2939

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163114.1 → XP_036019007.1 neurobeachin isoform X4

Conserved Domains (7) summary

sd00039
Location:2740 → 2794

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2282 → 2579

Beach; Beige/BEACH domain

pfam06469
Location:1950 → 2116

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2153 → 2250

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2693 → 2950

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006501523.4 → XP_006501586.1 neurobeachin isoform X12

See identical proteins and their annotated locations for XP_006501586.1

UniProtKB/Swiss-Prot

Q9EPN1

Conserved Domains (7) summary

sd00039
Location:2709 → 2763

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2277 → 2553

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2148 → 2245

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2662 → 2919

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006501519.4 → XP_006501582.1 neurobeachin isoform X6

Conserved Domains (7) summary

sd00039
Location:2735 → 2789

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2277 → 2574

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2148 → 2245

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2688 → 2945

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163117.1 → XP_036019010.1 neurobeachin isoform X10

Conserved Domains (7) summary

sd00039
Location:2720 → 2774

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2288 → 2564

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2159 → 2256

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2673 → 2930

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163116.1 → XP_036019009.1 neurobeachin isoform X9

Conserved Domains (7) summary

sd00039
Location:2725 → 2779

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2288 → 2564

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2159 → 2256

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2678 → 2935

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163113.1 → XP_036019006.1 neurobeachin isoform X3

Conserved Domains (7) summary

sd00039
Location:2741 → 2795

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2288 → 2585

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2159 → 2256

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2694 → 2951

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163111.1 → XP_036019004.1 neurobeachin isoform X1

Conserved Domains (7) summary

sd00039
Location:2746 → 2800

7WD40; WD40 repeat [structural motif]

pfam02138
Location:2288 → 2585

Beach; Beige/BEACH domain

pfam06469
Location:1956 → 2122

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2159 → 2256

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl29593
Location:2699 → 2956

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163119.1 → XP_036019012.1 neurobeachin isoform X15

Conserved Domains (6) summary

sd00039
Location:2255 → 2309

7WD40; WD40 repeat [structural motif]

pfam02138
Location:1797 → 2094

Beach; Beige/BEACH domain

pfam06469
Location:1465 → 1631

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:1668 → 1765

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:21 → 236

DUF4704; Domain of unknown function (DUF4704)

cl29593
Location:2208 → 2465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163122.1 → XP_036019015.1 neurobeachin isoform X20

Conserved Domains (4) summary

sd00039
Location:588 → 642

7WD40; WD40 repeat [structural motif]

pfam02138
Location:151 → 427

Beach; Beige/BEACH domain

pfam14844
Location:22 → 119

PH_BEACH; PH domain associated with Beige/BEACH

cl29593
Location:541 → 798

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030252626.1 → XP_030108486.1 neurobeachin isoform X21

Conserved Domains (4) summary

sd00039
Location:517 → 571

7WD40; WD40 repeat [structural motif]

pfam02138
Location:80 → 356

Beach; Beige/BEACH domain

cl17171
Location:2 → 48

PH-like; Pleckstrin homology-like domain

cl29593
Location:470 → 727

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036163121.1 → XP_036019014.1 neurobeachin isoform X17

Conserved Domains (2) summary

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_036163120.1 → XP_036019013.1 neurobeachin isoform X16

Conserved Domains (2) summary

pfam15787
Location:467 → 727

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_006501525.4 → XP_006501588.1 neurobeachin isoform X18

Conserved Domains (2) summary

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_006501526.5 → XP_006501589.1 neurobeachin isoform X19

Conserved Domains (2) summary

pfam15787
Location:462 → 733

DUF4704; Domain of unknown function (DUF4704)

cl22861
Location:245 → 392

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...