Mapk13 mitogen-activated protein kinase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk13provided by MGI
Official Full Name: mitogen-activated protein kinase 13provided by MGI
Primary source: MGI:MGI:1346864
See related: Ensembl:ENSMUSG00000004864 AllianceGenome:MGI:1346864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SAPK4; Serk4
Summary: Predicted to enable ATP binding activity and MAP kinase activity. Predicted to be involved in several processes, including cellular response to anisomycin; cellular response to sodium arsenite; and cellular response to sorbitol. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 152.1), colon adult (RPKM 106.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.0 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28988260..28997678)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28769286..28778704)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p38gamma and p38delta modulate innate immune response by regulating MEF2D activation.
Title: p38γ and p38δ modulate innate immune response by regulating MEF2D activation.
p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1.
Title: p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
p38delta genetic ablation protects female mice from anthracycline cardiotoxicity.
Title: p38δ genetic ablation protects female mice from anthracycline cardiotoxicity.
cell-specific p38delta targeting modifies susceptibility to chemical skin carcinogenesis in a context-, stage-, and sex-specific manner.
Title: Cell Type-Specific p38δ Targeting Reveals a Context-, Stage-, and Sex-Dependent Regulation of Skin Carcinogenesis.
These observations indicate that p38alpha probably blocks brown adipose tissue thermogenesis through p38delta inhibition.
Title: p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.
Study proposes MAPK p38delta protein as a key factor in breast cancer.
Title: P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment.
Results reveal that p38delta contributes both cell-autonomous and paracrine effects during the course of skin tumor formation.
Title: Keratinocyte p38δ loss inhibits Ras-induced tumor formation, while systemic p38δ loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin.
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
Title: p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.
p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
Title: p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.
Together, our results establish that p38gamma and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma and p38kappa as potential targets for cancer therapy.
Title: Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to anisomycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sorbitol	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 13

Names: MAP kinase 13; MAP kinase p38 delta; MAPK 13; SAPK/Erk/kinase 4; mitogen-activated protein kinase p38 delta; p38 delta MAP kinase; stress-activated protein kinase 4

NP_036080.2

EC 2.7.11.24

XP_017172968.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011950.2 → NP_036080.2 mitogen-activated protein kinase 13

See identical proteins and their annotated locations for NP_036080.2

Status: VALIDATED

Source sequence(s)

AK146993, CJ182359, U81823

Consensus CDS

CCDS28584.1

UniProtKB/Swiss-Prot

Q99M57, Q9Z1B7

UniProtKB/TrEMBL

A0A3F2YNL4, Q3UIB2

Related

ENSMUSP00000156387.2, ENSMUST00000233984.2

Conserved Domains (2) summary

cd07879
Location:9 → 351

STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)

smart00220
Location:30 → 308

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

28988260..28997678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317479.2 → XP_017172968.1 mitogen-activated protein kinase 13 isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain