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Map3k2 mitogen-activated protein kinase kinase kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 26405, updated on 21-Apr-2024

Summary

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Official Symbol
Map3k2provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 2provided by MGI
Primary source
MGI:MGI:1346873
See related
Ensembl:ENSMUSG00000024383 AllianceGenome:MGI:1346873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mekk2; Mekk2b; 9630061B06Rik
Summary
Predicted to enable MAP kinase kinase kinase activity and protein kinase binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 3.3), placenta adult (RPKM 2.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 17.95 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32296142..32369804)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32163089..32236751)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11799 Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene predicted gene, 26717 Neighboring gene predicted gene, 34806 Neighboring gene STARR-seq mESC enhancer starr_44156 Neighboring gene STARR-positive B cell enhancer ABC_E5649 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 3 Neighboring gene STARR-seq mESC enhancer starr_44157 Neighboring gene RIKEN cDNA A830052D11 gene Neighboring gene bridging integrator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'. Wu N, et al. J Mol Cell Biol, 2021 Sep 11. PMID 34010396, Free PMC Article
  2. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Wu N, et al. Nature, 2021 Apr. PMID 33658717
  3. Tumor-derived exosomes antagonize innate antiviral immunity. Gao L, et al. Nat Immunol, 2018 Mar. PMID 29358709
  4. MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase. Matitau AE, et al. J Biol Chem, 2013 Sep 27. PMID 23963453, Free PMC Article
  5. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Brown RD, et al. Am J Physiol Heart Circ Physiol, 2013 Jan 15. PMID 23125215, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
    Title: E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
  2. MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
    Title: MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
  3. Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'.
    Title: Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'.
  4. MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis.
    Title: MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis.
  5. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.
    Title: MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.
  6. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
    Title: MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
  7. Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
    Title: Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.
  8. FGF2/MEKK2 pathway mediates an alternative nonclassical pathway for beta-catenin activation, and this pathway is a key regulator of bone formation by osteoblasts
    Title: MEKK2 mediates an alternative β-catenin pathway that promotes bone formation.
  9. Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
    Title: Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
  10. methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas
    Title: SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 2
Names
MAP/ERK kinase kinase 2
MAPK/ERK kinase kinase 2
MEK kinase 2
MEKK 2
protein kinase MEKK2b
NP_036076.2
XP_036017049.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011946.3 → NP_036076.2  mitogen-activated protein kinase kinase kinase 2

    See identical proteins and their annotated locations for NP_036076.2

    Status: VALIDATED

    Source sequence(s)
    AC126686
    Consensus CDS
    CCDS29117.1
    UniProtKB/Swiss-Prot
    Q61083
    UniProtKB/TrEMBL
    G5E8L8
    Related
    ENSMUSP00000094326.4, ENSMUST00000096575.5
    Conserved Domains (2) summary
    cd06405
    Location:44 → 122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:353 → 616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32296142..32369804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161156.1 → XP_036017049.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q61083
    UniProtKB/TrEMBL
    G5E8L8
    Conserved Domains (2) summary
    cd06405
    Location:44 → 122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:353 → 616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61083.2 GenPept UniProtKB/Swiss-Prot:Q61083

Gene LinkOut

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