Spata2 spermatogenesis associated 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata2provided by MGI
Official Full Name: spermatogenesis associated 2provided by MGI
Primary source: MGI:MGI:2146885
See related: Ensembl:ENSMUSG00000047030 AllianceGenome:MGI:2146885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0757
Summary: Predicted to enable signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in protein linear deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within seminiferous tubule development and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human SPATA2 (spermatogenesis associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 17.1), colon adult (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.23 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (167323053..167334804, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167481136..167493238, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
Title: SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
Our data revealed the impact of SPATA2 on male fertility and suggested that SPATA2 ensures the normal secretory function of Sertoli cells
Title: Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice.
SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
Title: SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Spata2 can regulate inflammatory response and cell death in both RIPK1-dependent and RIPK1-independent manners
Title: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.
this study identifies SPATA2 as an important factor in the TNF signaling pathway with a substantial role for the effects mediated by the cytokine.
Title: SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237614

RH129821 (e-PCR)
- UniSTS:213109

AI504642 (e-PCR)
- UniSTS:160637

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein linear deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein linear deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein linear deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spermatogenesis-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356523.2 → NP_001343452.1 spermatogenesis-associated protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL589870

Consensus CDS

CCDS89587.1

Related

ENSMUSP00000104834.3, ENSMUST00000109211.9
NM_001411393.1 → NP_001398322.1 spermatogenesis-associated protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL589870

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004
NM_001411394.1 → NP_001398323.1 spermatogenesis-associated protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL589870

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004
NM_001411395.1 → NP_001398324.1 spermatogenesis-associated protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL589870

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004
NM_001411396.1 → NP_001398325.1 spermatogenesis-associated protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL589870

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004
NM_001411397.1 → NP_001398326.1 spermatogenesis-associated protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL589870

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004
NM_001411398.1 → NP_001398327.1 spermatogenesis-associated protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AL589870

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004
NM_001411416.1 → NP_001398345.1 spermatogenesis-associated protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AL589870
NM_001411417.1 → NP_001398346.1 spermatogenesis-associated protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL589870
NM_001411418.1 → NP_001398347.1 spermatogenesis-associated protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL589870
NM_001411419.1 → NP_001398348.1 spermatogenesis-associated protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL589870
NM_170756.3 → NP_739562.1 spermatogenesis-associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_739562.1

Status: VALIDATED

Source sequence(s)

AL589870

Consensus CDS

CCDS17100.1

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004

UniProtKB/TrEMBL

Q80TS6

Related

ENSMUSP00000057095.10, ENSMUST00000057627.16

Conserved Domains (1) summary

cd19757
Location:455 → 498

Bbox1; B-box-type 1 zinc finger (Bbox1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

167323053..167334804 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318650.3 → XP_017174139.1 spermatogenesis-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

Q3TAH0, Q3UML2, Q8K004

UniProtKB/TrEMBL

Q80TS6

Conserved Domains (1) summary

cd19757
Location:455 → 498

Bbox1; B-box-type 1 zinc finger (Bbox1)