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Fto FTO alpha-ketoglutarate dependent dioxygenase [ Mus musculus (house mouse) ]

Gene ID: 26383, updated on 21-Apr-2024

Summary

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Official Symbol
Ftoprovided by MGI
Official Full Name
FTO alpha-ketoglutarate dependent dioxygenaseprovided by MGI
Primary source
MGI:MGI:1347093
See related
Ensembl:ENSMUSG00000055932 AllianceGenome:MGI:1347093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1752
Summary
Enables DNA-N1-methyladenine dioxygenase activity; oxidative DNA demethylase activity; and oxidative RNA demethylase activity. Involved in several processes, including nucleic acid metabolic process; regulation of respiratory system process; and regulation of white fat cell proliferation. Located in nucleus. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and salivary gland. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 30.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C5; 8 44.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (92039995..92395061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91313367..91668433)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene abhydrolase domain containing 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22299 Neighboring gene predicted gene, 36163 Neighboring gene RIKEN cDNA 4831440D22 gene Neighboring gene STARR-seq mESC enhancer starr_22306 Neighboring gene STARR-seq mESC enhancer starr_22308 Neighboring gene uncharacterized LOC118567558 Neighboring gene STARR-seq mESC enhancer starr_22309 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FTO-dependent m(6)A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner. Wang W, et al. Clin Epigenetics, 2023 Jul 5. PMID 37408034, Free PMC Article
  2. Cerebroprotective Role of N(6)-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke. Chokkalla AK, et al. Stroke, 2023 Jan. PMID 36321453, Free PMC Article
  3. The m(6)A demethylase FTO promotes renal epithelial-mesenchymal transition by reducing the m(6)A modification of lncRNA GAS5. Li X, et al. Cytokine, 2022 Nov. PMID 36058192
  4. N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells. Tang S, et al. Clin Immunol, 2022 Aug. PMID 35878734
  5. FTO mediates LINE1 m(6)A demethylation and chromatin regulation in mESCs and mouse development. Wei J, et al. Science, 2022 May 27. PMID 35511947, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
    Title: The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
  2. MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
    Title: MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
  3. FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.
    Title: FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.
  4. A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
    Title: A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
  5. Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
    Title: Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
  6. FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
    Title: FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
  7. Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5.
    Title: Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5.
  8. Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy.
    Title: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy.
  9. FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-kappaB signaling pathway.
    Title: FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway.
  10. Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
    Title: Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
Submit: New GeneRIF Correction See all GeneRIFs (102)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables broad specificity oxidative DNA demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables broad specificity oxidative DNA demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables broad specificity oxidative DNA demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA N6-methyladenosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA N6-methyladenosine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidative RNA demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidative RNA demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA demethylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA alkylation repair ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of respiratory system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of white fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
involved_in temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-ketoglutarate-dependent dioxygenase FTO
Names
U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
fat mass and obesity associated
fat mass and obesity-associated protein
m6A(m)-demethylase FTO
mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
mRNA N(6)-methyladenosine demethylase FTO
protein fatso
tRNA N1-methyl adenine demethylase FTO
NP_036066.2
XP_006531099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011936.2 → NP_036066.2  alpha-ketoglutarate-dependent dioxygenase FTO

    See identical proteins and their annotated locations for NP_036066.2

    Status: VALIDATED

    Source sequence(s)
    BC057008, BY290198, CA321822
    Consensus CDS
    CCDS22521.1
    UniProtKB/Swiss-Prot
    Q3TTZ5, Q6ZPI7, Q8BGW1, Q8BR68, Q8CB66, Q8R250, Q9QZ13
    Related
    ENSMUSP00000068380.8, ENSMUST00000069718.15
    Conserved Domains (2) summary
    pfam12933
    Location:36 → 322
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:326 → 495
    FTO_CTD; FTO C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    92039995..92395061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531036.2 → XP_006531099.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

    UniProtKB/TrEMBL
    E9Q1E4
    Conserved Domains (1) summary
    pfam12933
    Location:40 → 252
    FTO_NTD; FTO catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGW1.1 GenPept UniProtKB/Swiss-Prot:Q8BGW1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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