Cetn2 centrin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cetn2provided by MGI
Official Full Name: centrin 2provided by MGI
Primary source: MGI:MGI:1347085
See related: Ensembl:ENSMUSG00000031347 AllianceGenome:MGI:1347085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Calt; caltractin; 1110034A02Rik
Summary: Enables G-protein beta/gamma-subunit complex binding activity; heterotrimeric G-protein binding activity; and microtubule binding activity. Acts upstream of or within spermatogenesis. Located in several cellular components, including 9+2 motile cilium; microtubule organizing center; and photoreceptor connecting cilium. Is expressed in 4th ventricle lateral recess; choroid plexus; and lateral ventricle choroid plexus. Orthologous to human CETN2 (centrin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 20.4), bladder adult (RPKM 16.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.29 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (71957137..71961967, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (72913565..72918344, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22).
Title: Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors.
This study demonistrated that CETN2 regulates protein trafficking of olfactory cilia and participates in specifying planar polarity of ependymal cilia.
Title: Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity.
Binding of Cen2 and Cen4 to Gbetagamma of non-visual G-proteins regulates G-proteins involved in centrosome and basal body functions
Title: Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables heterotrimeric G-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	IDA Inferred from Direct Assay more info	PubMed
part_of XPC complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
part_of transcription export complex 2	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrin-2

Names: caltractin, 20 kDa calcium binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019405.7 → NP_062278.2 centrin-2

See identical proteins and their annotated locations for NP_062278.2

Status: VALIDATED

Source sequence(s)

AL671908

Consensus CDS

CCDS41003.1

UniProtKB/Swiss-Prot

B1AUQ6, B1AUQ8, Q3UBB4, Q9CWM0, Q9R1K9

UniProtKB/TrEMBL

Z4YJH1

Related

ENSMUSP00000110198.4, ENSMUST00000114551.10

Conserved Domains (2) summary

PTZ00183
Location:16 → 172

PTZ00183; centrin; Provisional

cd00051
Location:105 → 167

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...