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Anxa10 annexin A10 [ Mus musculus (house mouse) ]

Gene ID: 26359, updated on 21-Apr-2024

Summary

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Official Symbol
Anxa10provided by MGI
Official Full Name
annexin A10provided by MGI
Primary source
MGI:MGI:1347090
See related
Ensembl:ENSMUSG00000031635 AllianceGenome:MGI:1347090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium ion binding activity. Located in mitochondrion. Orthologous to human ANXA10 (annexin A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward stomach adult (RPKM 61.0) See more
Orthologs
human all
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Genomic context

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Location:
8 B3.1; 8 31.55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (62510076..62576227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (62057042..62123193, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene DExD/H box helicase 60 Neighboring gene STARR-seq mESC enhancer starr_21603 Neighboring gene STARR-seq mESC enhancer starr_21604 Neighboring gene STARR-seq mESC enhancer starr_21605 Neighboring gene STARR-seq mESC enhancer starr_21607 Neighboring gene predicted gene 2961 Neighboring gene STARR-seq mESC enhancer starr_21609 Neighboring gene STARR-seq mESC enhancer starr_21610 Neighboring gene STARR-seq mESC enhancer starr_21611 Neighboring gene STARR-seq mESC enhancer starr_21612 Neighboring gene STARR-seq mESC enhancer starr_21613 Neighboring gene STARR-seq mESC enhancer starr_21614 Neighboring gene heat shock protein 1 (chaperonin), pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number variation is associated with embryonic mortality in Japanese Black cattle. Sasaki S, et al. BMC Genomics, 2016 Nov 24. PMID 27881083, Free PMC Article
  2. Annexin A10 is involved in the development and maintenance of neuropathic pain in mice. Lu Y, et al. Neurosci Lett, 2016 Sep 19. PMID 27507697
  3. Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3- mutant mice. Yamamoto A, et al. Dev Neurosci, 2014. PMID 25138526
  4. p57(Kip2) imposes the reserve stem cell state of gastric chief cells. Lee JH, et al. Cell Stem Cell, 2022 May 5. PMID 35523142, Free PMC Article
  5. Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. Seidlitz T, et al. Gastroenterology, 2019 Dec. PMID 31585123, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward beta-Cell Failure.
    Title: Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure.
  2. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.
    Title: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.
  3. Spinal nerve ligation (SNL) induced persistent upregulation of annexin A10 mRNA and protein in the spinal cord of mice. annexin A10 siRNA partially prevented SNL-induced mechanical allodynia and heat hyperalgesia. Findings suggest that annexin A10 might be a novel target in the treatment of neuropathic pain.
    Title: Annexin A10 is involved in the development and maintenance of neuropathic pain in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC159022

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
annexin A10
Names
annexin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136089.2 → NP_001129561.1  annexin A10 isoform 1

    See identical proteins and their annotated locations for NP_001129561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK131880, AK168715, BY083459
    Consensus CDS
    CCDS52558.1
    UniProtKB/Swiss-Prot
    Q3TGJ1, Q9QZ10
    UniProtKB/TrEMBL
    Q3V2F1
    Related
    ENSMUSP00000034052.7, ENSMUST00000034052.14
    Conserved Domains (1) summary
    pfam00191
    Location:93 → 158
    Annexin

  2. NM_011922.3 → NP_036052.2  annexin A10 isoform 2

    See identical proteins and their annotated locations for NP_036052.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK020288, AK131880, BY083459
    Consensus CDS
    CCDS52557.1
    UniProtKB/TrEMBL
    Q3V2F1, Q9D272
    Related
    ENSMUSP00000034054.8, ENSMUST00000034054.9
    Conserved Domains (2) summary
    pfam00191
    Location:231 → 296
    Annexin; Annexin
    cl02574
    Location:106 → 131
    Annexin; Annexin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    62510076..62576227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ10.2 GenPept UniProtKB/Swiss-Prot:Q9QZ10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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