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Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) [ Mus musculus (house mouse) ]

Gene ID: 26357, updated on 21-Apr-2024

Summary

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Official Symbol
Abcg2provided by MGI
Official Full Name
ATP binding cassette subfamily G member 2 (Junior blood group)provided by MGI
Primary source
MGI:MGI:1347061
See related
Ensembl:ENSMUSG00000029802 AllianceGenome:MGI:1347061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1
Summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney adult (RPKM 44.7), placenta adult (RPKM 44.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 27.82 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (58561476..58669436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (58584491..58692451)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 23 Neighboring gene predicted gene, 35077 Neighboring gene predicted gene, 45943 Neighboring gene STARR-seq mESC enhancer starr_16020 Neighboring gene STARR-seq mESC enhancer starr_16022 Neighboring gene STARR-seq mESC enhancer starr_16023 Neighboring gene predicted gene, 38822 Neighboring gene STARR-seq mESC enhancer starr_16024 Neighboring gene STARR-seq mESC enhancer starr_16025 Neighboring gene STARR-seq mESC enhancer starr_16026 Neighboring gene STARR-seq mESC enhancer starr_16027 Neighboring gene hect domain and RLD 3 Neighboring gene nucleosome assembly protein 1-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites. Álvarez-Fernández L, et al. J Pineal Res, 2023 Mar. PMID 36562106, Free PMC Article
  2. Role of the Abcg2 transporter in plasma levels and tissue accumulation of the anti-inflammatory tolfenamic acid in mice. Blanco-Paniagua E, et al. Chem Biol Interact, 2021 Aug 25. PMID 34062171
  3. ABCG2 Deficiency Does Not Alter Dolutegravir Metabolism and Pharmacokinetics. Zhu J, et al. J Pharmacol Exp Ther, 2020 Jul. PMID 32303561, Free PMC Article
  4. Abcg2 transporter affects plasma, milk and tissue levels of meloxicam. Garcia-Lino AM, et al. Biochem Pharmacol, 2020 May. PMID 32217099
  5. Bile Duct Obstruction Leads to Increased Intestinal Expression of Breast Cancer Resistance Protein With Reduced Gastrointestinal Absorption of Imatinib. Kawanishi T, et al. J Pharm Sci, 2019 Sep. PMID 31136764

See all (184) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
    Title: ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
  2. Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier.
    Title: Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier.
  3. GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms.
    Title: GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms.
  4. BCRP drives intrinsic chemoresistance in chemotherapy-naive breast cancer brain metastasis.
    Title: BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.
  5. Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1beta production in murine macrophage-like J774.1 cells.
    Title: Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1β production in murine macrophage-like J774.1 cells.
  6. Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
    Title: Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
  7. Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBalpha.
    Title: Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.
  8. Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin.
    Title: Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin.
  9. ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites.
    Title: ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites.
  10. Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice.
    Title: Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice.
Submit: New GeneRIF Correction See all GeneRIFs (127)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables biotin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables riboflavin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biotin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in glucuronoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intestinal absorption ISO
Inferred from Sequence Orthology
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in renal urate salt excretion ISO
Inferred from Sequence Orthology
more info
  
involved_in riboflavin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in riboflavin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transepithelial transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in external side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
broad substrate specificity ATP-binding cassette transporter ABCG2
Names
ATP-binding cassette sub-family G member 2
ATP-binding cassette, sub-family G (WHITE), member 2
breast cancer resistance protein 1 homolog
mitoxantrone resistance protein 1
urate exporter
NP_001342406.1
NP_001368854.1
NP_001368855.1
NP_001368856.1
NP_036050.1
XP_006506213.1
XP_011239664.1
XP_030111259.1
XP_030111260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355477.2 → NP_001342406.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    Consensus CDS
    CCDS20195.1
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  2. NM_001381925.1 → NP_001368854.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  3. NM_001381926.1 → NP_001368855.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  4. NM_001381927.1 → NP_001368856.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121859
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Related
    ENSMUSP00000109933.2, ENSMUST00000114294.8
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  5. NM_011920.3 → NP_036050.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    See identical proteins and their annotated locations for NP_036050.1

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859, AF103875, AI428558, AK087830, CO039662
    Consensus CDS
    CCDS20195.1
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Related
    ENSMUSP00000031822.7, ENSMUST00000031822.13
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    58561476..58669436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241362.1 → XP_011239664.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    See identical proteins and their annotated locations for XP_011239664.1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  2. XM_030255399.2 → XP_030111259.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  3. XM_030255400.1 → XP_030111260.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  4. XM_006506150.5 → XP_006506213.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    See identical proteins and their annotated locations for XP_006506213.1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46 → 651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMS5.1 GenPept UniProtKB/Swiss-Prot:Q7TMS5

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