U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF337 zinc finger protein 337 [ Homo sapiens (human) ]

Gene ID: 26152, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF337provided by HGNC
Official Full Name
zinc finger protein 337provided by HGNC
Primary source
HGNC:HGNC:15809
See related
Ensembl:ENSG00000130684 AllianceGenome:HGNC:15809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in ovary (RPKM 5.9), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF337 in Genome Data Viewer
Location:
20p11.21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (25673195..25696853, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25738693..25762362, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (25653831..25677489, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ZNF337 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 594, pseudogene Neighboring gene mediator complex subunit 28 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17674 Neighboring gene uncharacterized LOC107985400 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25699573-25700088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25700089-25700604 Neighboring gene vomeronasal 1 receptor 108 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17675 Neighboring gene uncharacterized LOC105372582

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. Mao CG, et al. Thorac Cancer, 2020 Nov. PMID 33001583, Free PMC Article
  2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  3. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 337

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034058.1 RefSeqGene

    Range
    5052..28710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290261.2 → NP_001277190.1  zinc finger protein 337

    See identical proteins and their annotated locations for NP_001277190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK125455, AL031673, BC021298, BX113975
    Consensus CDS
    CCDS13174.1
    UniProtKB/Swiss-Prot
    B4DSM2, Q9Y3M9, Q9Y3Y5
    Related
    ENSP00000365619.1, ENST00000376436.5
    Conserved Domains (7) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:234 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:530 → 554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600 → 633
    DUF4193; Domain of unknown function (DUF4193)

  2. NM_015655.4 → NP_056470.1  zinc finger protein 337

    See identical proteins and their annotated locations for NP_056470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK291235, AL031673, BC021298, BP201424, BX113975
    Consensus CDS
    CCDS13174.1
    UniProtKB/Swiss-Prot
    B4DSM2, Q9Y3M9, Q9Y3Y5
    Related
    ENSP00000252979.5, ENST00000252979.6
    Conserved Domains (7) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:234 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:530 → 554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600 → 633
    DUF4193; Domain of unknown function (DUF4193)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    25673195..25696853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260702.4 → XP_005260759.1  zinc finger protein 337 isoform X2

    See identical proteins and their annotated locations for XP_005260759.1

    UniProtKB/Swiss-Prot
    Q9Y3M9
    Conserved Domains (7) summary
    smart00349
    Location:12 → 52
    KRAB; krueppel associated box
    COG5048
    Location:202 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:318 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:316 → 338
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:358 → 383
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:568 → 601
    DUF4193; Domain of unknown function (DUF4193)

  2. XM_011529219.3 → XP_011527521.1  zinc finger protein 337 isoform X1

    See identical proteins and their annotated locations for XP_011527521.1

    UniProtKB/Swiss-Prot
    B4DSM2, Q9Y3M9, Q9Y3Y5
    Conserved Domains (7) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:234 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:530 → 554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600 → 633
    DUF4193; Domain of unknown function (DUF4193)

  3. XM_006723558.5 → XP_006723621.1  zinc finger protein 337 isoform X1

    See identical proteins and their annotated locations for XP_006723621.1

    UniProtKB/Swiss-Prot
    B4DSM2, Q9Y3M9, Q9Y3Y5
    Conserved Domains (7) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:234 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:530 → 554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600 → 633
    DUF4193; Domain of unknown function (DUF4193)

  4. XM_017027803.3 → XP_016883292.1  zinc finger protein 337 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y3M9
    Conserved Domains (7) summary
    smart00349
    Location:12 → 52
    KRAB; krueppel associated box
    COG5048
    Location:202 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:318 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:316 → 338
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:358 → 383
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:568 → 601
    DUF4193; Domain of unknown function (DUF4193)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    25738693..25762362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323348.1 → XP_054179323.1  zinc finger protein 337 isoform X2

  2. XM_054323347.1 → XP_054179322.1  zinc finger protein 337 isoform X1

    UniProtKB/Swiss-Prot
    B4DSM2, Q9Y3M9, Q9Y3Y5

  3. XM_054323346.1 → XP_054179321.1  zinc finger protein 337 isoform X1

    UniProtKB/Swiss-Prot
    B4DSM2, Q9Y3M9, Q9Y3Y5

  4. XM_054323349.1 → XP_054179324.1  zinc finger protein 337 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3M9.2 GenPept UniProtKB/Swiss-Prot:Q9Y3M9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous