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GORASP2 golgi reassembly stacking protein 2 [ Homo sapiens (human) ]

Gene ID: 26003, updated on 5-Mar-2024

Summary

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Official Symbol
GORASP2provided by HGNC
Official Full Name
golgi reassembly stacking protein 2provided by HGNC
Primary source
HGNC:HGNC:17500
See related
Ensembl:ENSG00000115806 MIM:608693; AllianceGenome:HGNC:17500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p59; GRS2; GOLPH6; GRASP55
Summary
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 25.6), placenta (RPKM 23.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (170928477..170967130)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171405614..171444257)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171784987..171823640)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ERICH2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12092 Neighboring gene glutamate rich 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12093 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_55930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:171674788-171675311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:171675312-171675834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171679351-171680150 Neighboring gene glutamate decarboxylase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16744 Neighboring gene Sharpr-MPRA regulatory region 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12094 Neighboring gene uncharacterized LOC124906091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:171833995-171834551 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:171840298-171840798 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:171840799-171841299 Neighboring gene NANOG hESC enhancer GRCh37_chr2:171902444-171902951 Neighboring gene tousled like kinase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr2:171959352-171959858 Neighboring gene uncharacterized LOC124906092

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production. Yang F, et al. Int J Mol Sci, 2023 Jun 14. PMID 37373263, Free PMC Article
  2. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. Pothukuchi P, et al. EMBO J, 2021 Oct 18. PMID 34516001, Free PMC Article
  3. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Nüchel J, et al. Mol Cell, 2021 Aug 19. PMID 34245671, Free PMC Article
  4. GRASP55: A Multifunctional Protein. Wu H, et al. Curr Protein Pept Sci, 2020. PMID 32067616
  5. Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution. Reddy ST, et al. Eur Biophys J, 2020 Mar. PMID 31915857

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.
    Title: Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.
  2. GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.
    Title: GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.
  3. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
    Title: GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
  4. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
    Title: An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
  5. Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
    Title: Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
  6. GRASP55: A Multifunctional Protein.
    Title: GRASP55: A Multifunctional Protein.
  7. Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.
    Title: Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.
  8. GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
    Title: GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
  9. that SIRT2 regulates Golgi structure by modulating GRASP55 acetylation levels
    Title: SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly.
  10. here we identified a novel GORASP2-ALK rearrangement in a patient with ALK + LBCL with a unique ALK immunohistochemical staining pattern.
    Title: Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of golgi reassembly stacking protein 2 (GORASP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13139, DKFZp434D156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cis-Golgi network NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Golgi reassembly-stacking protein 2
Names
golgi phosphoprotein 6
golgi reassembly stacking protein 2, 55kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201428.2 → NP_001188357.1  Golgi reassembly-stacking protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001188357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010092, AL117430, BQ004408
    UniProtKB/TrEMBL
    B4DNR1
    Conserved Domains (1) summary
    pfam04495
    Location:1 → 137
    GRASP55_65; GRASP55/65 PDZ-like domain

  2. NM_015530.5 → NP_056345.3  Golgi reassembly-stacking protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056345.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010092, BC007770, BQ004408
    Consensus CDS
    CCDS33325.1
    UniProtKB/Swiss-Prot
    B4DKT0, Q53TE3, Q96I74, Q96K84, Q9H8Y8, Q9H946, Q9UFW4
    UniProtKB/TrEMBL
    B4DNR1
    Related
    ENSP00000234160.4, ENST00000234160.5
    Conserved Domains (3) summary
    pfam04495
    Location:69 → 205
    GRASP55_65; GRASP55/65 PDZ-like domain
    cl00117
    Location:14 → 100
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl26464
    Location:241 → 397
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    170928477..170967130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    171405614..171444257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H8Y8.3 GenPept UniProtKB/Swiss-Prot:Q9H8Y8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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