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SYF2 SYF2 pre-mRNA splicing factor [ Homo sapiens (human) ]

Gene ID: 25949, updated on 5-Mar-2024

Summary

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Official Symbol
SYF2provided by HGNC
Official Full Name
SYF2 pre-mRNA splicing factorprovided by HGNC
Primary source
HGNC:HGNC:19824
See related
Ensembl:ENSG00000117614 MIM:607090; AllianceGenome:HGNC:19824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P29; CBPIN; NTC31; fSAP29
Summary
This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 39.9), ovary (RPKM 37.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25222276..25232502, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25058533..25068759, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (25548767..25558993, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 447 Neighboring gene uncharacterized LOC124903880 Neighboring gene IFITM3 pseudogene 7 Neighboring gene MPRA-validated peak125 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25494962-25495462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25510715-25511215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25525541-25526040 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:25528106-25528280 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:25554020-25555219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 452 Neighboring gene uncharacterized LOC124903881 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25559103-25560016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25565284-25566070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25566071-25566856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25572736-25573460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:25573461-25574185 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25580071-25580587 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:25580588-25581105 Neighboring gene arginine and serine rich protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:25593225-25593742 Neighboring gene uncharacterized LOC105376882 Neighboring gene Rh blood group D antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of SYF2 correlates with enhanced cell growth and poor prognosis in human hepatocellular carcinoma. Zhang S, et al. Mol Cell Biochem, 2015 Dec. PMID 26260052
  2. SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation. Yan S, et al. Tumour Biol, 2015 Jun. PMID 25623116
  3. Involvement of p29/SYF2/fSAP29/NTC31 in the progression of NSCLC via modulating cell proliferation. Liu Y, et al. Pathol Res Pract, 2015 Jan. PMID 25433998
  4. Upregulation of SYF2 in esophageal squamous cell carcinoma promotes tumor cell proliferation and predicts poor prognosis. Zhu J, et al. Tumour Biol, 2014 Oct. PMID 25034528
  5. Knocking down the expression of SYF2 inhibits the proliferation of glioma cells. Guo J, et al. Med Oncol, 2014 Aug. PMID 24985881

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA HOST2 enhances gefitinib-resistance in non-small cell lung cancer by down-regulating miRNA-621.
    Title: LncRNA HOST2 enhances gefitinib-resistance in non-small cell lung cancer by down-regulating miRNA-621.
  2. These data identify Aletrnative splicing programs controlled by ZRANB2 and SYF2 and converging on ECT2, that participate to breast cancer cell resistance to doxorubicin.
    Title: ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin.
  3. SYF2 might play a regulatory role in the proliferation of hepatocellular carcinoma cells.
    Title: Overexpression of SYF2 correlates with enhanced cell growth and poor prognosis in human hepatocellular carcinoma.
  4. we support that SYF2 might contribute to EOC progression via modulation of proliferation in EOC cells and would provide a novel therapeutic target of human epithelial ovarian cancer
    Title: SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation.
  5. p29 might contribute to the progression of non-small cell lung cancer by enhancing cell proliferation, implicating that targeting p29 might provide beneficial effects on the clinical therapy of non-small cell lung cancer
    Title: Involvement of p29/SYF2/fSAP29/NTC31 in the progression of NSCLC via modulating cell proliferation.
  6. SYF2 in glioma is essential for cell proliferation.
    Title: Knocking down the expression of SYF2 inhibits the proliferation of glioma cells.
  7. Our findings for the first time supported that SYF2 might play an important role in the regulation of esophageal squamous cell carcinoma proliferation
    Title: Upregulation of SYF2 in esophageal squamous cell carcinoma promotes tumor cell proliferation and predicts poor prognosis.
  8. novel function of p29 in the regulation of DNA replication checkpoint responses in Hela cells.
    Title: Silencing of p29 affects DNA damage responses with UV irradiation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564O2082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing factor SYF2
Names
CCNDBP1 interactor
GCIP-interacting protein p29
SYF2 homolog, RNA splicing factor
functional spliceosome-associated protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015484.5 → NP_056299.1  pre-mRNA-splicing factor SYF2 isoform 1

    See identical proteins and their annotated locations for NP_056299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL031432, BC010862, DR155437
    Consensus CDS
    CCDS259.1
    UniProtKB/Swiss-Prot
    O95926, Q5TH73
    UniProtKB/TrEMBL
    B2RBX8
    Related
    ENSP00000236273.4, ENST00000236273.9
    Conserved Domains (1) summary
    pfam08231
    Location:90 → 238
    SYF2; SYF2 splicing factor

  2. NM_207170.4 → NP_997053.1  pre-mRNA-splicing factor SYF2 isoform 2

    See identical proteins and their annotated locations for NP_997053.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform 2) is shorter than isoform 1 and lacks both bipartite nuclear localization signals found in isoform 1.
    Source sequence(s)
    AL031432, BC010862, CV806249, DR155437
    Consensus CDS
    CCDS258.1
    UniProtKB/TrEMBL
    B2RBX8
    Related
    ENSP00000346330.3, ENST00000354361.3
    Conserved Domains (1) summary
    pfam08231
    Location:48 → 196
    SYF2; SYF2 splicing factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    25222276..25232502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25058533..25068759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95926.1 GenPept UniProtKB/Swiss-Prot:O95926

Gene LinkOut

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