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Srgap3 SLIT-ROBO Rho GTPase activating protein 3 [ Mus musculus (house mouse) ]

Gene ID: 259302, updated on 11-Apr-2024

Summary

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Official Symbol
Srgap3provided by MGI
Official Full Name
SLIT-ROBO Rho GTPase activating protein 3provided by MGI
Primary source
MGI:MGI:2152938
See related
Ensembl:ENSMUSG00000030257 AllianceGenome:MGI:2152938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbi; WRP; MEGAP; Arhgap14; mKIAA0411; D130026O08Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study schizophrenia. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 27.6), CNS E18 (RPKM 23.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Srgap3 in Genome Data Viewer
Location:
6 E3; 6 52.54 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112694932..112924466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112717971..112947505, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11330 Neighboring gene predicted gene, 35824 Neighboring gene predicted gene, 26799 Neighboring gene STARR-seq mESC enhancer starr_17023 Neighboring gene predicted gene, 57496 Neighboring gene STARR-seq mESC enhancer starr_17024 Neighboring gene STARR-seq mESC enhancer starr_17025 Neighboring gene VISTA enhancer mm1480 Neighboring gene STARR-seq mESC enhancer starr_17026 Neighboring gene STARR-positive B cell enhancer mm9_chr6:112812032-112812333 Neighboring gene Yip1 interacting factor homolog A pseudogene Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene, 23244

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Morphological and behavioral characterization of adult mice deficient for SrGAP3. Bertram J, et al. Cell Tissue Res, 2016 Oct. PMID 27184948
  2. SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle. Koschützke L, et al. Cell Tissue Res, 2015 Aug. PMID 26104135
  3. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. Kim IH, et al. J Biol Chem, 2012 Nov 9. PMID 23007397, Free PMC Article
  4. Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. Waltereit R, et al. FASEB J, 2012 Nov. PMID 22820399
  5. The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells. Chen K, et al. Cell Mol Neurobiol, 2011 Jul. PMID 21350945

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SrGAP3 plays a role in neurodevelopmental disorders.
    Title: Morphological and behavioral characterization of adult mice deficient for SrGAP3.
  2. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice.
    Title: SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle.
  3. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins.
    Title: The cellular function of srGAP3 and its role in neuronal morphogenesis.
  4. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
    Title: The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
  5. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus
    Title: Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
  6. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.
    Title: Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.
  7. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14.
    Title: Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.
  8. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1.
    Title: SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions.
  9. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.
    Title: Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.
  10. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner.
    Title: The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
SLIT-ROBO Rho GTPase-activating protein 3
Names
SLIT-ROBO Rho GTPase activating protein 2
WAVE-associated Rac GTPase-activating protein
brain stress early protein Gbi
rho GTPase-activating protein 14
srGAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080448.4 → NP_536696.4  SLIT-ROBO Rho GTPase-activating protein 3

    See identical proteins and their annotated locations for NP_536696.4

    Status: VALIDATED

    Source sequence(s)
    AC153591, AK051262, AY057899, CF744803, CK032058
    Consensus CDS
    CCDS39590.1
    UniProtKB/Swiss-Prot
    Q80U09, Q812A2, Q8BKP4, Q8BLD0, Q925I2
    UniProtKB/TrEMBL
    F8VPQ4
    Related
    ENSMUSP00000085712.5, ENSMUST00000088373.11
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748 → 800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502 → 689
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    112694932..112924466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506145.2 → XP_006506208.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q80U09, Q812A2, Q8BKP4, Q8BLD0, Q925I2
    UniProtKB/TrEMBL
    E9QN14
    Related
    ENSMUSP00000108794.3, ENSMUST00000113169.9
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:724 → 776
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:481 → 665
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

  2. XM_030255398.1 → XP_030111258.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X4

    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748 → 800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502 → 689
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

  3. XM_006506146.2 → XP_006506209.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X3

    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753 → 805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510 → 694
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

  4. XM_006506144.2 → XP_006506207.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q80U09, Q812A2, Q8BKP4, Q8BLD0, Q925I2
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753 → 805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510 → 694
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

RNA

  1. XR_004942960.1 RNA Sequence

  2. XR_004942959.1 RNA Sequence

  3. XR_004942958.1 RNA Sequence

  4. XR_004942961.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153070.1: Suppressed sequence

    Description
    NM_153070.1: This RefSeq was permanently suppressed because it was entirely 3' UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q812A2.1 GenPept UniProtKB/Swiss-Prot:Q812A2

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