TAS2R45 taste 2 receptor member 45 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R45provided by HGNC
Official Full Name: taste 2 receptor member 45provided by HGNC
Primary source: HGNC:HGNC:18876
See related: MIM:613967; AllianceGenome:HGNC:18876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR59; T2R45; ZG24P
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of taste. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: only annotated on alternate loci in reference assembly
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Genomic context

Location:: 12p13.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12 (ALT_REF_LOCI_2)	NT_187658.1 (291887..292786, complement)
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12 (ALT_REF_LOCI_1)	NW_003571050.1 (327525..328424, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (10966219..10967118, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12 (PATCHES)	NW_003571050.1 (327525..328424, complement)

NW_003571050.1 Genomic Context describing neighboring genes

NT_187658.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484184

NoName (e-PCR)
- UniSTS:484185

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
NOT enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 45

Names: G-protein coupled receptor 59; taste receptor, type 2, member 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176886.2 → NP_795367.2 taste receptor type 2 member 45

See identical proteins and their annotated locations for NP_795367.2

Status: VALIDATED

Source sequence(s)

AC217021

UniProtKB/Swiss-Prot

P59539

UniProtKB/TrEMBL

A0A0J9YXD8

Conserved Domains (1) summary

pfam05296
Location:1 → 298

TAS2R; Taste receptor protein (TAS2R)